The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila
Open accessAbstract
SUMMARY Stem cell division is essential for tissue integrity during growth, aging, and pathogenic assaults. Adult gastrointestinal tract encounters numerous stimulations and impaired tissue regeneration may lead to inflammatory diseases and cancer. Intestinal stem cells in adult Drosophila have recently been identified and shown to replenish the various cell types within the midgut. However, it is not known whether these intestinal stem cells can respond to environmental challenges. By feeding dextran sulfate sodium and bleomycin to flies and by expressing apoptotic proteins, we show that Drosophila intestinal stem cells can increase the rate of division in response to tissue damage. Moreover, if tissue damage results in epithelial cell loss, the newly formed enteroblasts can differentiate into mature epithelial cells. By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Cited by
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila
Buchon, N., Osman, D., David, F. P. A., Yu Fang, H., Boquete, J.-P., Deplancke, B., & Lemaitre, B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.001 · Cited by 513
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel
He, L., Si, G., Huang, J., Samuel, A. D. T., & Perrimon, N. (2018) · Nature · doi:10.1038/nature25744 · Cited by 348
Bacteria and host interactions in the gut epithelial barrier
Ashida, H., Ogawa, M., Kim, M., Mimuro, H., & Sasakawa, C. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.741 · Cited by 337
Metadata
- Authors
- Amcheslavsky, A., Jiang, J., & Ip, Y. T.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 4
- Issue
- 1
- Pages
- 49-61
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2051909115
- Cited by
- 542
- References
- 1
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila. https://app.cochat.ai/papers/10.1016/j.stem.2008.10.016
- The paper
- Amcheslavsky, A., Jiang, J., & Ip, Y. T. (2009). Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila. Cell Stem Cell. https://doi.org/10.1016/j.stem.2008.10.016
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
