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Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential

Benveniste, Patricia, Frelin, Catherine, Janmohamed, Salima, Barbara, Mary, Herrington, Robert, Hyam, Deborah, Iscove, Norman N.·2010·Cell Stem Cell
DOI 10.1016/j.stem.2009.11.014
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Abstract

Sustained blood cell production depends on divisions by hematopoietic stem cells (HSCs) that yield both differentiating progeny as well as new HSCs via self-renewal. Differentiating progeny remain capable of self-renewal, but only HSCs sustain self-renewal through successive divisions securely enough to maintain clones that persist life-long. Until recently, the first identified next stage consisted of "short-term" reconstituting cells able to sustain clones of differentiating cells for only 4-6 weeks. Here we expand evidence for a numerically dominant "intermediate-term" multipotent HSC stage in mice whose clones persist for 6-8 months before becoming extinct and that are separable from both short-term as well as permanently reconstituting "long-term" HSCs. The findings suggest that the first step in stem cell differentiation consists not in loss of initial capacity for serial self-renewal divisions, but rather in loss of mechanisms that stabilize self-renewing behavior throughout successive future stem cell divisions.

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Metadata

Authors
Benveniste, P., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., & Iscove, N. N.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2010-01
Volume
6
Issue
1
Pages
48-58
ISSN
1934-5909
DOI
10.1016/j.stem.2009.11.014
Cited by
216
References
2
Language
en
Licence

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CoChat. (2026). Citation check: Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential. https://app.cochat.ai/papers/10.1016/j.stem.2009.11.014
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Benveniste, P., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., & Iscove, N. N. (2010). Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential. Cell Stem Cell. https://doi.org/10.1016/j.stem.2009.11.014