Hematopoiesis: a human perspective

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1

Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036 · see citing works

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822 · see citing works

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,770 · see citing works

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168 · see citing works

Purification and Characterization of Mouse Hematopoietic Stem Cells

Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,889 · see citing works

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706 · see citing works

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617 · see citing works

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570 · see citing works

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253 · see citing works

A severe combined immunodeficiency mutation in the mouse

Bosma, G. C., Custer, R. P., & Bosma, M. J. (1983) · Nature · doi:10.1038/301527a0 · Cited by 2,223 · see citing works

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159 · see citing works

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141 · see citing works

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908 · see citing works

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S. D., King, M., Mangada, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6477 · Cited by 1,736 · see citing works

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711 · see citing works

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578 · see citing works

Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells

Becker, A., Mcculloch, E., & Till, J. (1963) · Nature · doi:10.1038/197452a0 · Cited by 1,570 · see citing works

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564 · see citing works

A Stem Cell Molecular Signature

Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543 · see citing works

Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin

Hanna, J. H., Wernig, M., Markoulaki, S., Sun, C., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L.-C., Townes, T. M., et al. (2007) · Science · doi:10.1126/science.1152092 · Cited by 1,493 · see citing works

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

Ito, M., Hiramatsu, H., Kobayashi, K., Suzue, K., Kawahata, M., Hioki, K., Ueyama, Y., Koyanagi, Y., Sugamura, K., Tsuji, K., et al. (2002) · Blood · doi:10.1182/blood-2001-12-0207 · Cited by 1,483 · see citing works

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works

Deletion of <i>IKZF1</i> and Prognosis in Acute Lymphoblastic Leukemia

Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808253 · Cited by 1,422 · see citing works

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

McCune, J. M., Namikawa, R., Kaneshima, H., Shultz, L. D., Lieberman, M., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2971269 · Cited by 1,404 · see citing works

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

Noguchi, M. (1993) · Cell · doi:10.1016/0092-8674(93)90167-o · Cited by 1,338 · see citing works

MLL translocations, histone modifications and leukaemia stem-cell development

Krivtsov, A., & Armstrong, S. (2007) · Nature Reviews. Cancer · doi:10.1038/nrc2253 · Cited by 1,294 · see citing works

Human bone marrow colony growth in agar‐gel

Pike, B. L., & Robinson, W. A. (1970) · Journal of Cellular Physiology · doi:10.1002/jcp.1040760111 · Cited by 1,289 · see citing works

Humanized mice in translational biomedical research

Shultz, L. D., Ishikawa, F., & Greiner, D. L. (2007) · Nature reviews. Immunology · doi:10.1038/nri2017 · Cited by 1,281 · see citing works

Transfer of a functional human immune system to mice with severe combined immunodeficiency

Mosier, D. E., Gulizia, R. J., Baird, S. M., & Wilson, D. B. (1988) · Nature · doi:10.1038/335256a0 · Cited by 1,258 · see citing works

Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential

Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,229 · see citing works

Multiple defects in innate and adaptive immunologic function in NOD/LtSz- scid mice.

Shultz, L. D., Schweitzer, P. A., Christianson, S. W., Gott, B., Schweitzer, I. B., Tennent, B. J., McKenna, S., Mobraaten, L. E., Rajan, T. V., Greiner, D. L., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.1.180 · Cited by 1,224 · see citing works

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

Civin, C., Strauss, L. C., Brovall, C., Fackler, M., Schwartz, J. F., & Shaper, J. H. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.1.157 · Cited by 1,200 · see citing works

Steady-state and inflammatory dendritic-cell development

Shortman, K., & Naik, S. H. (2006) · Nature reviews. Immunology · doi:10.1038/nri1996 · Cited by 1,180 · see citing works

Stem cell concepts renew cancer research.

Dick, J. (2008) · Blood · doi:10.1182/blood-2008-08-077941 · Cited by 1,126 · see citing works

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Großer, T., et al. (2007) · Nature · doi:10.1038/nature05883 · Cited by 1,095 · see citing works

Isolation of a candidate human hematopoietic stem-cell population.

Baum, C. M., Weissman, I. L., Tsukamoto, A. S., Buckle, A., & Péault, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2804 · Cited by 1,084 · see citing works

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S., Walker, J., Flaveny, C. A., Perdew, G., Denison, M., et al. (2010) · Science · doi:10.1126/science.1191536 · Cited by 1,058 · see citing works

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050 · see citing works

Humanized mice in translational biomedical research

Shultz, L. (2007) · The Mouseion at the JAXlibrary (Jackson Laboratory) · Cited by 1,036 · see citing works

Stem cell gene expression programs influence clinical outcome in human leukemia

Eppert, K., Takenaka, K., Lechman, E. R., Waldron, L., Nilsson, B., van Galen, P., Metzeler, K. H., Poeppl, A. G., Ling, V., Beyene, J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2415 · Cited by 1,032 · see citing works

Rules for Making Human Tumor Cells

Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951 · see citing works

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

Novershtern, N., Subramanian, A., Lawton, L. N., Mak, R. H., Haining, W. N., McConkey, M. E., Habib, N., Yosef, N., Chang, C. Y., Shay, T., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.004 · Cited by 942 · see citing works

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

Notta, F., Doulatov, S., Laurenti, E., Poeppl, A., Jurisica, I., & Dick, J. E. (2011) · Science · doi:10.1126/science.1201219 · Cited by 919 · see citing works

A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

Till, J. E., McCulloch, E. A., & Siminovitch, L. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.1.29 · Cited by 907 · see citing works

Stems Cells and the Pathways to Aging and Cancer

Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works

<i>In vivo</i> proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3120 · Cited by 858 · see citing works

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice

Bhatia, M., Wang, J. C. Y., Kapp, U., Bonnet, D. A., & Dick, J. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5320 · Cited by 849 · see citing works

HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

Kyba, M., Perlingeiro, R., & Daley, G. (2002) · Cell · doi:10.1016/s0092-8674(02)00680-3 · Cited by 822 · see citing works

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

Puel, A., Ziegler, S. F., Buckley, R. H., & Leonard., W. J. (1998) · Nature Genetics · doi:10.1038/3877 · Cited by 813 · see citing works

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

Delaney, C. S., Heimfeld, S., Brashem‐Stein, C., Voorhies, H., Manger, R. L., & Bernstein, I. D. (2010) · Nature Medicine · doi:10.1038/nm.2080 · Cited by 769 · see citing works

Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

Adolfsson, J., Borge, O. J., Bryder, D., Theilgaard‐Mönch, K., Åstrand‐Grundström, I., Sitnicka, E., Sasaki, Y., & Jacobsen, S. E. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00220-5 · Cited by 712 · see citing works

HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700 · see citing works

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

Goessling, W., North, T. E., Loewer, S., Lord, A. M., Lee, S., Stoick-Cooper, C. L., Weidinger, G., Puder, M., Daley, G. Q., Moon, R. T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.015 · Cited by 699 · see citing works

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

Raya, Á., Rodríguez-Pizà, I., Güenechea, G., Vassena, R., Navarro, S., Barrero, M. J., Consiglio, A., Castellà, M., Rı́o, P., Sleep, E., et al. (2009) · Nature · doi:10.1038/nature08129 · Cited by 690 · see citing works

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

Galy, A. H. M., Travis, M. A., Cen, D., & Chen, B. P. C. (1995) · Immunity · doi:10.1016/1074-7613(95)90175-2 · Cited by 686 · see citing works

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

Sutherland, H., Eaves, C. J., Eaves, A., Dragowska, W. H., & Lansdorp, P. (1989) · Blood · doi:10.1182/blood.v74.5.1563.1563 · Cited by 678 · see citing works

Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.

Goardon, N., Marchi, E., Atzberger, A., Quek, L., Schuh, A., Soneji, S., Woll, P., Mead, A., Alford, K., Rout, R., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.012 · Cited by 671 · see citing works

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

Lathia, J. D., Gallagher, J., Heddleston, J. M., Wang, J., Eyler, C. E., MacSwords, J., Wu, Q., Vasanji, A., McLendon, R. E., Hjelmeland, A. B., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.02.018 · Cited by 655 · see citing works

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

Varnum‐Finney, B., Xu, L., Brashem‐Stein, C., Nourigat, C., Flowers, D. A., Bakkour, S., Pear, W. S., & Bernstein, I. D. (2000) · Nature Medicine · doi:10.1038/81390 · Cited by 642 · see citing works

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

Ikuta, K., & Weissman, I. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1502 · Cited by 637 · see citing works

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P. N., Doi, A., Lindau, P., Lee, H.-J., Aryee, M. J., Irizarry, R. A., Kim, K., et al. (2010) · Nature · doi:10.1038/nature09367 · Cited by 636 · see citing works

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

Hsu, A. P., Sampaio, E. P., Khan, J. I., Calvo, K. R., Lemieux, J. E., Patel, S. Y., Frucht, D. M., Vinh, D. C., Auth, R., Freeman, A. F., et al. (2011) · Blood · doi:10.1182/blood-2011-05-356352 · Cited by 635 · see citing works

Disruption of differentiation in human cancer: AML shows the way

Tenen, D. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc989 · Cited by 612 · see citing works

Long-term culture of human bone marrow cells.

Gartner, S., & Kaplan, H. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.8.4756 · Cited by 611 · see citing works

A newly discovered class of human hematopoietic cells with SCID-repopulating activity

Bhatia, M., Bonnet, D. A., Murdoch, B., Gan, O. I., & Dick, J. E. (1998) · Nature Medicine · doi:10.1038/2023 · Cited by 608 · see citing works

IRF8 Mutations and Human Dendritic-Cell Immunodeficiency

Hambleton, S., Salem, S., Bustamante, J. C., Bigley, V., Boisson‐Dupuis, S., Azevedo, J., Fortin, A., Haniffa, M. A., Ceron‐Gutierrez, L., Bacon, C. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100066 · Cited by 604 · see citing works

Identification of a Hierarchy of Multipotent Hematopoietic Progenitors in Human Cord Blood

Majeti, R., Park, C. Y., & Weissman, I. L. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.10.001 · Cited by 603 · see citing works

Transcription Factor GATA-2 Is Required for Proliferation/Survival of Early Hematopoietic Cells and Mast Cell Formation, But Not for Erythroid and Myeloid Terminal Differentiation

Tsai, F., & Orkin, S. H. (1997) · Blood · doi:10.1182/blood.v89.10.3636.3636_3636_3643 · Cited by 601 · see citing works

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

Mohrin, M., Bourke, E., Alexander, D., Warr, M. R., Barry-Holson, K., Le Beau, M. M., Morrison, C. G., & Passegué, E. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.014 · Cited by 599 · see citing works

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., & Hock, H. (2009) · Nature Biotechnology · doi:10.1038/nbt.1517 · Cited by 586 · see citing works

Modification of Irradiation Injury in Mice and Guinea Pigs by Bone Marrow Injections

Lorenz, E., Uphoff, D. E., Reid, T. R., & Shelton, E. (1951) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/12.1.197 · Cited by 586 · see citing works

Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice

Lapidot, T., Pflumio, F., Doedens, M., Murdoch, B., Williams, D. E., & Dick, J. E. (1992) · Science · doi:10.1126/science.1372131 · Cited by 534 · see citing works

The scid mutation in mice causes a general defect in DNA repair

Fulop, G. M., & Phillips, R. A. (1990) · Nature · doi:10.1038/347479a0 · Cited by 532 · see citing works

Prospective isolation of human clonogenic common myeloid progenitors

Manz, M. G., Miyamoto, T., Akashi, K., & Weissman, I. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172384399 · Cited by 529 · see citing works

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells

Takenaka, K., Prasolava, T. K., Wang, J. C. Y., Mortin-Toth, S. M., Khalouei, S., Gan, O. I., Dick, J. E., & Danska, J. S. (2007) · Nature Immunology · doi:10.1038/ni1527 · Cited by 510 · see citing works

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development

Doulatov, S. R., Notta, F., Eppert, K., Nguyen, L. T., Ohashi, P. S., & Dick, J. E. (2010) · Nature Immunology · doi:10.1038/ni.1889 · Cited by 510 · see citing works

Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay

Wang, J. C. Y., Doedens, M., & Dick, J. E. (1997) · Blood · doi:10.1182/blood.v89.11.3919 · Cited by 487 · see citing works

Identification of a lineage of multipotent hematopoietic progenitors

Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E., & Weissman, I. L. (1997) · Development · doi:10.1242/dev.124.10.1929 · Cited by 482 · see citing works

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Bröske, A.-M., Vockentanz, L., Kharazi, S., Huska, M. R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., et al. (2009) · Nature Genetics · doi:10.1038/ng.463 · Cited by 478 · see citing works

Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells

Kamel‐Reid, S., & Dick, J. E. (1988) · Science · doi:10.1126/science.2904703 · Cited by 472 · see citing works

The earliest thymic progenitors for T cells possess myeloid lineage potential

Bell, J. J., & Bhandoola, A. (2008) · Nature · doi:10.1038/nature06840 · Cited by 460 · see citing works

Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic– scid/scid mice

Conneally, E., Cashman, J., Petzer, A. L., & Eaves, C. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9836 · Cited by 448 · see citing works

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

Dickinson, R. E., Griffin, H. R., Bigley, V., Reynard, L. N., Hussain, R., Haniffa, M. A., Lakey, J. H., Rahman, T., Wang, X.-N., McGovern, N. N., et al. (2011) · Blood · doi:10.1182/blood-2011-06-360313 · Cited by 434 · see citing works

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU

Kiel, M. J., He, S., Ashkenazi, R., Gentry, S. N., Teta, M., Kushner, J. A., Jackson, T. L., & Morrison, S. J. (2007) · Nature · doi:10.1038/nature06115 · Cited by 417 · see citing works

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancerPreprint

Neumüller, R. A., & Knoblich, J. A. (2009) · Genes & Development · doi:10.1101/gad.1850809 · Cited by 402 · see citing works

Developmental and species-divergent globin switching are driven by BCL11A

Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., et al. (2009) · Nature · doi:10.1038/nature08243 · Cited by 379 · see citing works

Modeling the Initiation and Progression of Human Acute Leukemia in Mice

Barabé, F., Kennedy, J., Hope, K. J., & Dick, J. E. (2007) · Science · doi:10.1126/science.1139851 · Cited by 375 · see citing works

Adult T-cell progenitors retain myeloid potential

Wada, H., Masuda, K., Satoh, R., Kakugawa, K., Ikawa, T., Katsura, Y., & Kawamoto, H. (2008) · Nature · doi:10.1038/nature06839 · Cited by 368 · see citing works

Infection of the SCID-hu Mouse by HIV-1

Namikawa, R., Kaneshima, H., Lieberman, M., et al. (1988) · Science · doi:10.1126/science.3201256 · Cited by 367 · see citing works

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Wei, J., Wunderlich, M., Fox, C. F., Álvarez, S., Cigudosa, J., Wilhelm, J., Zheng, Y., Cancelas, J., Gu, Y., Jansen, M., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.04.020 · Cited by 354 · see citing works

Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors

Månsson, R., Hultquist, A., Luc, S., Yang, L., Anderson, K., Kharazi, S., Al-Hashmi, S., Liuba, K., Thorén, L., Adolfsson, J., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.013 · Cited by 353 · see citing works

In Vitro Colony Formation by Normal and Leukemic Human Hematopoietic Cells: Characterization of the Colony-Forming Cells 2

Moore, M. A. S., Williams, N., & Metcalf, D. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/50.3.603 · Cited by 352 · see citing works

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.

Jude, C. D., Climer, L. K., Xu, D.-Y., Artinger, E. L., Fisher, J., & Ernst, P. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.05.019 · Cited by 350 · see citing works

A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis.

Collins, L., & Dorshkind, K. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.4.1082 · Cited by 340 · see citing works

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

Vinh, D. C., Patel, S. Y., Uzel, G., Anderson, V., Freeman, A. F., Olivier, K. N., Spalding, C. D., Hughes, S. M., Pittaluga, S., Raffeld, M. A., et al. (2009) · Blood · doi:10.1182/blood-2009-03-208629 · Cited by 330 · see citing works

Fate Mapping Reveals Separate Origins of T Cells and Myeloid Lineages in the Thymus

Schlenner, S., Madan, V., Busch, K., Tietz, A., Läufle, C., Costa, C., Blum, C., Fehling, H. J., & Rodewald, H.-R. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.005 · Cited by 322 · see citing works

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.011 · Cited by 317 · see citing works

Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow

伊藤, 克. (1990) · Medical Entomology and Zoology · Cited by 309 · see citing works

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

Bigley, V., Haniffa, M. A., Doulatov, S. R., Wang, X., Dickinson, R. E., McGovern, N. N., Jardine, L., Pagan, S., Dimmick, I., Chua, I. C., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101459 · Cited by 304 · see citing works

Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro

Motte-Mohs, R. N. L., Herer, E., & Zúñiga‐Pflücker, J. C. (2004) · Blood · doi:10.1182/blood-2004-04-1293 · Cited by 303 · see citing works

Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopicHOXB4expression

Wang, L., Menéndez, P. R., Shojaei, F., Li, L., Mazurier, F., Dick, J. E., Cerdan, C., Levac, K. D., & Bhatia, M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041888 · Cited by 297 · see citing works

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis

Rodrigues, N. P. (2005) · Blood · doi:10.1182/blood-2004-08-2989 · Cited by 292 · see citing works

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

Himburg, H. A., Muramoto, G. G., Daher, P., Meadows, S. K., Russell, J. L., Doan, P. L., Chi, J., Salter, A. B., Lento, W. E., Reya, T., et al. (2010) · Nature Medicine · doi:10.1038/nm.2119 · Cited by 286 · see citing works

Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

Mazurier, F., Doedens, M., Gan, O. I., & Dick, J. E. (2003) · Nature Medicine · doi:10.1038/nm886 · Cited by 282 · see citing works

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

Milyavsky, M., Gan, O. I., Trottier, M., Komosa, M., Tabach, O., Notta, F., Lechman, E. R., Hermans, K. G., Eppert, K., Konovalova, Z., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.05.016 · Cited by 280 · see citing works

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

Amsellem, S., Pflumio, F., Bardinet, D., Izac, B., Charneau, P., Roméo, P., Dubart‐Kupperschmitt, A., & Fichelson, S. (2003) · Nature Medicine · doi:10.1038/nm953 · Cited by 279 · see citing works

Human Immunodeficiency Virus Infection of Human-PBL-SCID Mice

Mosier, D. E., Gulizia, R. J., Baird, S. M., et al. (1991) · Science · doi:10.1126/science.1990441 · Cited by 278 · see citing works

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

Goessling, W., Allen, R. S., Guan, X., Jin, P., Uchida, N., Dovey, M. C., Harris, J. M., Metzger, M. E., Bonifacino, A. C., Stroncek, D. F., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.003 · Cited by 267 · see citing works

Definitive Hematopoiesis Requires the Mixed-Lineage Leukemia Gene

Ernst, P., Fisher, J. K., Avery, W., Wade, S., Foy, D. S., & Korsmeyer, S. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00061-9 · Cited by 265 · see citing works

The replication rate of human hematopoietic stem cells in vivo

Catlin, S. N., Busque, L., Gale, R. E., Guttorp, P., & Abkowitz, J. L. (2011) · Blood · doi:10.1182/blood-2010-08-303537 · Cited by 259 · see citing works

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

Hao, Q., Thiemann, F., Petersen, D., Smogorzewska, E. M., & Crooks, G. (1996) · Blood · doi:10.1182/blood.v88.9.3306.bloodjournal8893306 · Cited by 258 · see citing works

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

Lansdorp, P. M., Sutherland, H. J., & Eaves, C. J. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.1.363 · Cited by 257 · see citing works

Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast

Stingl, J., Eaves, C. J., Kuusk, U., & Emerman, J. T. (1998) · Differentiation · doi:10.1111/j.1432-0436.1998.00201.x · Cited by 252 · see citing works

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

Sutherland, H., Eaves, C. J., Lansdorp, P., Thacker, J. D., & Hogge, D. E. (1991) · Blood · doi:10.1182/blood.v78.3.666.666 · Cited by 249 · see citing works

Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

Trowbridge, J. J., Xenocostas, A., Moon, R. T., & Bhatia, M. (2005) · Nature Medicine · doi:10.1038/nm1339 · Cited by 247 · see citing works

Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation

Zhang, C. C., Kaba, M., Iizuka, S., Huynh, H., & Lodish, H. F. (2008) · Blood · doi:10.1182/blood-2007-11-122119 · Cited by 246 · see citing works

Evidence that hematopoiesis may be a stochastic process in vivo

Abkowitz, J. L., Catlin, S. N., & Guttorp, P. M. (1996) · Nature Medicine · doi:10.1038/nm0296-190 · Cited by 246 · see citing works

All Hematopoietic Cells Develop from Hematopoietic Stem Cells through Flk2/Flt3-Positive Progenitor Cells

Boyer, S. W., Schroeder, A. V., Smith‐Berdan, S., & Forsberg, E. C. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.021 · Cited by 245 · see citing works

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

Lagresle‐Peyrou, C., Six, E. M., Pïcard, C., Rieux‐Laucat, F., Michel, V., Ditadi, A., Demerens, C., Morillon, E., Valensi, F., Simon-Stoos, K. L., et al. (2008) · Nature Genetics · doi:10.1038/ng.278 · Cited by 234 · see citing works

Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential

Benveniste, P. M., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., & Iscove, N. N. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.11.014 · Cited by 217 · see citing works

Enrichment of human hematopoietic stem cell activity in the CD34+Thy- 1+Lin- subpopulation from mobilized peripheral blood

Murray, L. J., Chen, B., Galy, A. H. M., Chen, S., Tushinski, R. J., Uchida, N., Negrin, R. S., Tricot, G. J. K., Jagannath, S., & Vesole, D. H. (1995) · Blood · doi:10.1182/blood.v85.2.368.368 · Cited by 212 · see citing works

Gfi1 and Gfi1b: key regulators of hematopoiesis

van der Meer, L. T., Jansen, J. H., & van der Reijden, B. A. (2010) · Leukemia · doi:10.1038/leu.2010.195 · Cited by 211 · see citing works

Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells

Ohishi, K., Varnum‐Finney, B., & Bernstein, I. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16167 · Cited by 208 · see citing works

Identification of a novel, human multilymphoid progenitor in cord blood

Hao, Q., Zhu, J., Price, M. A., Payne, K. J., Barsky, L. W., & Crooks, G. M. (2001) · Blood · doi:10.1182/blood.v97.12.3683 · Cited by 204 · see citing works

The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway

Sakamoto, K., Yamaguchi, S., Ando, R., Miyawaki, A., Kabasawa, Y., Takagi, M., Li, C. L., Perbal, B., & Katsube, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203727200 · Cited by 202 · see citing works

Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis

Koch, U., Wilson, A., Cobas, M., Kemler, R., MacDonald, H. R., & Radtke, F. (2007) · Blood · doi:10.1182/blood-2007-07-099754 · Cited by 201 · see citing works

Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-β2 microglobulin–null mice

Glimm, H., Eisterer, W., Lee, K., Cashman, J., Holyoake, T. L., Nicolini, F. E., Shultz, L. D., Kalle, C. V., & Eaves, C. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11519 · Cited by 198 · see citing works

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Rongvaux, A., Willinger, T., Takizawa, H., Rathinam, C., Auerbach, W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Eynon, E. E., Stevens, S. G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019524108 · Cited by 191 · see citing works

Familial myelodysplasia and acute myeloid leukaemia – a review

Owen, C., Barnett, M. J., & Fitzgibbon, J. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06909.x · Cited by 186 · see citing works

Proliferation of Haemopoietic Stem Cells in Vitro

Dexter, T. M., & Lajtha, L. G. (1974) · British Journal of Haematology · doi:10.1111/j.1365-2141.1974.tb06671.x · Cited by 177 · see citing works

Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer

Negrin, R. S., Atkinson, K., Leemhuis, T., Hanania, E. G., Juttner, C. A., Tierney, K., Hu, W. W., Johnston, L., Shizuru, J. A., Stockerl-Goldstein, K. E., et al. (2000) · Transplantation and Cellular Therapy · doi:10.1016/s1083-8791(00)70008-5 · Cited by 167 · see citing works

Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis

Rizo, A., Olthof, S. G. M., Han, L., Vellenga, E., de Haan, G., & Schuringa, J. J. (2009) · Blood · doi:10.1182/blood-2009-03-209734 · Cited by 163 · see citing works

Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgc-null recipients

Notta, F., Doulatov, S. R., & Dick, J. E. (2010) · Blood · doi:10.1182/blood-2009-10-249326 · Cited by 148 · see citing works

Genetic Defects in Severe Congenital Neutropenia: Emerging Insights into Life and Death of Human Neutrophil Granulocytes

Klein, C. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101259 · Cited by 146 · see citing works

Interleukin 7 independent development of human B cells.

Prieyl, J. A., & LeBien, T. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10348 · Cited by 146 · see citing works

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

Buske, C. (2002) · Blood · doi:10.1182/blood-2002-01-0220 · Cited by 135 · see citing works

Dynamics of Thymus-Colonizing Cells during Human Development

Haddad, R., Guimiot, F., Six, E. M., Jourquin, F., Setterblad, N., Kahn, E., Yagello, M., Schiffer, C., André‐Schmutz, I., Cavazzana, M., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.008 · Cited by 133 · see citing works

B lymphopoiesis is active throughout human life, but there are developmental age-related changes

Rossi, M. I. D., Yokota, T., Medina, K. L., Garrett, K. P., Comp, P. C., Schipul, A. H., & Kincade, P. W. (2002) · Blood · doi:10.1182/blood-2002-03-0896 · Cited by 132 · see citing works

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

Willinger, T., Rongvaux, A., Strowig, T., Manz, M. G., & Flavell, R. A. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.005 · Cited by 128 · see citing works

Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells

Sitnicka, E., Buza-Vidas, N., Larsson, S., Nygren, J., Liuba, K., & Jacobsen, S. E. W. (2003) · Blood · doi:10.1182/blood-2002-06-1694 · Cited by 128 · see citing works

Microarray and Serial Analysis of Gene Expression Analyses Identify Known and Novel Transcripts Overexpressed in Hematopoietic Stem Cells

Georgantas, R. W., Tanavde, V., Malehorn, M., Heimfeld, S., Chen, C., Carr, L., Martínez-Murillo, F., Riggins, G., Kowalski, J., & Civin, C. I. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3247 · Cited by 127 · see citing works

A human postnatal lymphoid progenitor capable of circulating and seeding the thymus

Six, E. M., Bonhomme, D., Monteiro, M., Beldjord, K., Jurkowska, M., Cordier, C., Garrigue, A., Cortivo, L. D., Rocha, B., Fischer, A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071003 · Cited by 127 · see citing works

NOV (CCN3) Functions as a Regulator of Human Hematopoietic Stem or Progenitor Cells

Gupta, R., Hong, D., Iborra, F. J., Sarno, S. M., & Enver, T. (2007) · Science · doi:10.1126/science.1136031 · Cited by 126 · see citing works

Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis

Billips, L. G., Petitte, D., Dorshkind, K. A., Narayanan, R., Chiu, C., & Landreth, K. S. (1992) · Blood · doi:10.1182/blood.v79.5.1185.1185 · Cited by 121 · see citing works

T Lymphocytes Are Direct, Aryl Hydrocarbon Receptor (AhR)-Dependent Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): AhR Expression in Both CD4+ and CD8+ T Cells Is Necessary for Full Suppression of a Cytotoxic T Lymphocyte Response by TCDD

Kerkvliet, N. I. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9537 · Cited by 117 · see citing works

Umbilical Cord Blood Transplantation and Banking

Brunstein, C. G., & Wagner, J. E. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.57.051804.123642 · Cited by 113 · see citing works

Notch signaling in mammalian hematopoietic stem cells

Pajcini, K. V., Speck, N. A., & Pear, W. S. (2011) · Leukemia · doi:10.1038/leu.2011.127 · Cited by 111 · see citing works

Clonal Type I Interferon–producing and Dendritic Cell Precursors Are Contained in Both Human Lymphoid and Myeloid Progenitor Populations

Chicha, L., Jarrossay, D., & Manz, M. G. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040809 · Cited by 111 · see citing works

Evolving views on the genealogy of B cells

Welner, R. S., Pelayo, R., & Kincade, P. W. (2008) · Nature reviews. Immunology · doi:10.1038/nri2234 · Cited by 108 · see citing works

Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1

Rizo, A., Dontje, B., Vellenga, E., de Haan, G., & Schuringa, J. J. (2007) · Blood · doi:10.1182/blood-2007-08-106666 · Cited by 106 · see citing works

Adhesion within the stem cell niches

Raymond, K., Deugnier, M., Faraldo, M. M., & Glukhova, M. A. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.05.004 · Cited by 101 · see citing works

Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths

Shepherd, B. E., Guttorp, P. M., Lansdorp, P. M., & Abkowitz, J. L. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.07.023 · Cited by 98 · see citing works

Surprising new roles for PU.1 in the adaptive immune response

Carotta, S., Wu, L., & Nutt, S. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00955.x · Cited by 93 · see citing works

PLZF is a regulator of homeostatic and cytokine-induced myeloid developmentPreprint

Doulatov, S. R., Notta, F., Rice, K. L., Howell, L., Zelent, A., Licht, J. D., & Dick, J. E. (2009) · Genes & Development · doi:10.1101/gad.1788109 · Cited by 93 · see citing works

A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid‐based model

Kawamoto, H., Ikawa, T., Masuda, K., Wada, H., & Katsura, Y. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00959.x · Cited by 89 · see citing works

T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34+CD38−CD7+ common lymphoid progenitors expressing lymphoid-specific genes

Hoebeke, I., Smedt, M. D., Stolz, F., Pike‐Overzet, K., Staal, F. J. T., Plum, J. R., & Leclercq, G. (2006) · Leukemia · doi:10.1038/sj.leu.2404488 · Cited by 89 · see citing works

DER LYMPHOZYT ALS GEMEINSAME STAMMZELLE DER VERSCHIEDENEN BLUTELEMENTE IN DER EMBRYONALEN ENTWICKLUNG UND IM POSTFETALEN LEBEN DER SäUGETIERE

Alexander, A. (2009) · Cellular Therapy and Transplantation · Cited by 78 · see citing works

Hierarchical and Ontogenic Positions Serve to Define the Molecular Basis of Human Hematopoietic Stem Cell Behavior

Shojaei, F., Trowbridge, J. J., Gallacher, L. M., Yuefei, L., Goodale, D. B., Karanu, F., Levac, K. D., & Bhatia, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.004 · Cited by 72 · see citing works

Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cells

Schuringa, J. J., & Vellenga, E. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328338c439 · Cited by 71 · see citing works

FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells

Buza-Vidas, N., Woll, P. S., Hultquist, A., Duarte, S., Lutteropp, M., Bouriez‐Jones, T., Ferry, H., Luc, S., & Jacobsen, S. E. W. (2011) · Blood · doi:10.1182/blood-2010-10-316232 · Cited by 70 · see citing works

Emergence of T Cell Progenitors Without B Cell or Myeloid Differentiation Potential at the Earliest Stage of Hematopoiesis in the Murine Fetal Liver

Kawamoto, H., Ohmura, K., Fujimoto, S., & Katsura, Y. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2725 · Cited by 68 · see citing works

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers

Larochelle, A., Savona, M. R., Wiggins, M. A., Anderson, S., Ichwan, B., Keyvanfar, K., Morrison, S. J., & Dunbar, C. E. (2010) · Blood · doi:10.1182/blood-2009-03-212803 · Cited by 60 · see citing works

In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors

Ehrlich, L. I. R., Serwold, T. F., & Weissman, I. L. (2010) · Blood · doi:10.1182/blood-2010-05-287102 · Cited by 58 · see citing works

A dominant-negative mutant of C/EBPα, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse

Schwieger, M., Löhler, J., Fischer, M., Herwig, U., Tenen, D. G., & Stocking, C. (2003) · Blood · doi:10.1182/blood-2003-07-2280 · Cited by 56 · see citing works

Multiple extrathymic precursors contribute to T-cell development with different kinetics

Saran, N., Łyszkiewicz, M., Pommerencke, J., Witzlau, K., Vakilzadeh, R., Ballmaier, M., von Boehmer, H., & Krueger, A. (2009) · Blood · doi:10.1182/blood-2009-07-230821 · Cited by 56 · see citing works

TCDD Treatment Eliminates the Long-Term Reconstitution Activity of Hematopoietic Stem Cells

Sakai, R. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg002 · Cited by 53 · see citing works

Clinical Applications of CD34 + Peripheral Blood Progenitor Cells (PBPC)

Vogel, W., Scheding, S., Kanz, L., et al. (2000) · Stem Cells · doi:10.1634/stemcells.18-2-87 · Cited by 46 · see citing works

Development of a high-resolution purification method for precise functional characterization of primitive human cord blood–derived CD34–negative SCID-repopulating cells

Ishii, M., Matsuoka, Y., Sasaki, Y., et al. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.11.008 · Cited by 37 · see citing works

Development and Activation of Human Dendritic Cells In Vivo in a Xenograft Model of Human Hematopoiesis

Cravens, P. D., Melkus, M. W., Padgett‐Thomas, A., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0116 · Cited by 33 · see citing works

Unmanipulated or CD34 selected haplotype mismatched transplants

Kang, Y., Chao, N. J. A., & Aversa, F. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32831366eb · Cited by 32 · see citing works

Investigation of C/EBPα function in human (versus murine) myelopoiesis provides novel insight into the impact of CEBPA mutations in acute myelogenous leukemia (AML)

Niebuhr, B., Iwanski, G. B., Schwieger, M., et al. (2008) · Leukemia · doi:10.1038/leu.2008.332 · Cited by 15 · see citing works

Ex Vivo Expansion of Human and Murine Hematopoietic Stem Cells

Miller, C., Audet, J., & Eaves, C. J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-140-x:189 · Cited by 14 · see citing works

Cancer stem cells revisited

Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769 · see citing works

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413 · see citing works

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443 · see citing works

Gene therapy returns to centre stage

Naldini, L. (2015) · Nature · doi:10.1038/nature15818 · Cited by 1,184 · see citing works

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Dever, D. P., Bak, R. O., Reinisch, A., Camarena, J., Washington, G., Nicolas, C. E., Pavel-Dinu, M., Saxena, N., Wilkens, A. B., Mantri, S., et al. (2016) · Nature · doi:10.1038/nature20134 · Cited by 864 · see citing works

Chromatin state dynamics during blood formation

Lara-Astiaso, D., Weiner, A., Lorenzo-Vivas, E., Zaretsky, I., Jaitin, D. A., David, E., Keren-Shaul, H., Mildner, A., Winter, D., Jung, S., et al. (2014) · Science · doi:10.1126/science.1256271 · Cited by 776 · see citing works

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

Notta, F., Zandi, S., Takayama, N., Dobson, S., Gan, O. I., Wilson, G., Kaufmann, K. B., McLeod, J., Laurenti, E., Dunant, C. F., et al. (2016) · Science · doi:10.1126/science.aab2116 · Cited by 780 · see citing works

Targeted genome editing in human repopulating haematopoietic stem cells

Genovese, P., Schiroli, G., Escobar, G., Di Tomaso, T., Firrito, C., Calabria, A., Moi, D., Mazzieri, R., Bonini, C., Holmes, M. C., et al. (2014) · Nature · doi:10.1038/nature13420 · Cited by 555 · see citing works

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

Bowman, R. L., Busque, L., & Levine, R. L. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.011 · Cited by 448 · see citing works

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

Khajuria, R. K., Munschauer, M., Ulirsch, J. C., Fiorini, C., Ludwig, L. S., McFarland, S. K., Abdulhay, N. J., Specht, H., Keshishian, H., Mani, D. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.036 · Cited by 416 · see citing works

A comprehensive single cell transcriptional landscape of human hematopoietic progenitors

Pellin, D., Loperfido, M., Baricordi, C., Wolock, S. L., Montepeloso, A., Weinberg, O. K., Biffi, A., Klein, A. M., & Biasco, L. (2019) · Nature Communications · doi:10.1038/s41467-019-10291-0 · Cited by 360 · see citing works

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

Schiroli, G., Conti, A., Ferrari, S., della Volpe, L., Jacob, A., Albano, L., Beretta, S., Calabria, A., Vavassori, V., Gasparini, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.02.019 · Cited by 342 · see citing works

CRISPR/Cas9 genome editing in human hematopoietic stem cells.

Bak, R. O., Dever, D. P., & Porteus, M. H. (2018) · Nature Protocols · doi:10.1038/nprot.2017.143 · Cited by 319 · see citing works

Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors

Wang, J., Exline, C. M., DeClercq, J. J., Llewellyn, G. N., Hayward, S. B., Li, P. W.-L., Shivak, D. A., Surosky, R. T., Gregory, P. D., Holmes, M. C., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3408 · Cited by 261 · see citing works

In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early and steady-state reconstitution phases

Biasco, L., Pellin, D., Scala, S., Dionisio, F., Basso-Ricci, L., Leonardelli, L., Scaramuzza, S., Baricordi, C., Ferrua, F., Cicalese, M. P., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.016 · Cited by 243 · see citing works

Interrogation of human hematopoiesis at single-cell and single-variant resolution

Ulirsch, J. C., Lareau, C. A., Bao, E. L., Ludwig, L. S., Guo, M. H., Benner, C., Satpathy, A. T., Kartha, V. K., Salem, R. M., Hirschhorn, J. N., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0362-6 · Cited by 208 · see citing works

An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program

Gnani, D., Crippa, S., della Volpe, L., Rossella, V., Conti, A., Lettera, E., Rivis, S., Ometti, M., Fraschini, G., Bernardo, M. E., et al. (2019) · Aging Cell · doi:10.1111/acel.12933 · Cited by 188 · see citing works

Unraveling Hematopoiesis through the Lens of Genomics

Liggett, L. A., & Sankaran, V. G. (2020) · Cell · doi:10.1016/j.cell.2020.08.030 · Cited by 163 · see citing works

Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate

Palii, C. G., Cheng, Q., Gillespie, M. A., Shannon, P., Mazurczyk, M., Napolitani, G., Price, N. D., Ranish, J. A., Morrissey, E., Higgs, D. R., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.02.006 · Cited by 148 · see citing works

Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6

Bak, R. O., Dever, D. P., Reinisch, A., Cruz Hernandez, D., Majeti, R., & Porteus, M. H. (2017) · eLife · doi:10.7554/elife.27873 · Cited by 122 · see citing works

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Piras, F., Riba, M., Petrillo, C., Lazarevic, D., Cuccovillo, I., Bartolaccini, S., Stupka, E., Gentner, B., Cittaro, D., Naldini, L., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707922 · Cited by 75 · see citing works

The impact of aging on primate hematopoiesis as interrogated by clonal tracking

Yu, K.-R., Espinoza, D. A., Wu, C., Truitt, L., Shin, T.-H., Chen, S., Fan, X., Yabe, I. M., Panch, S., Hong, S. G., et al. (2018) · Blood · doi:10.1182/blood-2017-08-802033 · Cited by 47 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Triangles Triply in Perspective

M‘Leod, C., & Milne, W. P. (1909) · Proceedings of the Edinburgh Mathematical Society · doi:10.1017/s001309150003488x

Creative perspective for artists and designers

West, K. R. (1995) · Medical Entomology and Zoology

Participation of humoral factors in the regulation of hemopoiesis in cytostatic myelodepression

Дыгай, А. М., Жданов, В. В., Minakova, M. Y., et al. (1997) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf02445085

Results Perspective One : Network Perspective

Bentivegna, T. (2013) · Springer eBooks · doi:10.1007/978-3-658-04579-1_5