The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
Open accessAbstract
The cytokine leukemia inhibitory factor (Lif) sustains self-renewal of mouse embryonic and induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3. Here we investigate whether Jak/Stat3 may also contribute to induction of pluripotency. EpiSCs derived from postimplantation embryos express low levels of Lif receptor and Stat3. We introduced into EpiSCs a Jak/Stat3 activating receptor (GY118F) responsive to granulocyte colony stimulating factor (Gcsf). On transfer to ground state culture, in which MAPK signaling and glycogen synthase kinase are inhibited, Gcsf induced transcriptional resetting and functional reprogramming. Activation of a tamoxifen-regulatable fusion, Stat3ER(T2), also converted EpiSCs into chimera-competent iPSCs. We exploited GY118F to increase Jak/Stat3 activity during somatic cell reprogramming. Incompletely reprogrammed cells derived from neural stem cells or fibroblasts responded to Gcsf with elevated frequencies of progression to ground state pluripotency. These findings indicate that Jak/Stat3 participate directly in molecular reprogramming and that activation of this pathway is a limiting component.
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Cites
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Self-citationA parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
Niwa, H., Ogawa, K., Shimosato, D., & Adachi, K. (2009) · Nature · doi:10.1038/nature08113 · Cited by 872
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12848 · Cited by 388 · cited 1×
“Furthermore, because tyrosine 118 is also the binding site for the negative feedback regulator Socs3 (Schmitz et al., 2000), GY118F induces elevated and sustained activation of Jak/Stat3 (Burdon et al.”
Background
Cited by
Jinushi, M., Chiba, S., Yoshiyama, H., Masutomi, K., Kinoshita, I., Dosaka-Akita, H., Yagita, H., Takaoka, A., & Tahara, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106645108 · Cited by 479
Leukemia inhibitory factor (LIF)
Nicola, N. A., & Babon, J. J. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.001 · Cited by 478
Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells
Festuccia, N., Osorno, R., Halbritter, F., Karwacki-Neisius, V., Navarro, P., Colby, D., Wong, F., Yates, A., Tomlinson, S. R., & Chambers, I. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.08.002 · Cited by 334
Obokata, H., Sasai, Y., Niwa, H., Kadota, M., Andrabi, M., Takata, N., Tokoro, M., Terashita, Y., Yonemura, S., Vacanti, C. A., et al. (2014) · Nature · doi:10.1038/nature13599 · Cited by 313
RetractedThe SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency
Saunders, A., Huang, X., Fidalgo, M., Reimer, M. H., Faiola, F., Ding, J., Sánchez-Priego, C., Guallar, D., Sáenz, C., Li, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.055 · Cited by 92
Metadata
- Authors
- Yang, J., van Oosten, A. L., Theunissen, T. W., Guo, G., Silva, J. C. R., & Smith, A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 7
- Issue
- 3
- Pages
- 319-328
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2161347865
- Cited by
- 236
- References
- 3
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, J., van Oosten, A. L., Theunissen, T. W., Guo, G., Silva, J. C. R., & Smith, A. (2010). Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency. Cell Stem Cell. https://doi.org/10.1016/j.stem.2010.06.022
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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