The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells
Open accessAbstract
Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog expression. However, the mechanisms by which Nanog functions remain unclear, and in particular, direct Nanog target genes are uncharacterized. Here we investigate ESCs expressing different Nanog levels and Nanog(-/-) cells with distinct functionally inducible Nanog proteins to identify Nanog-responsive genes. Surprisingly, these constitute a minor fraction of genes that Nanog binds. Prominent among Nanog-reponsive genes is Estrogen-related receptor b (Esrrb). Nanog binds directly to Esrrb, enhances binding of RNAPolII, and stimulates Esrrb transcription. Overexpression of Esrrb in ESCs maintains cytokine-independent self-renewal and pluripotency. Remarkably, this activity is retained in Nanog(-/-) ESCs. Moreover, Esrrb can reprogram Nanog(-/-) EpiSCs and can rescue stalled reprogramming in Nanog(-/-) pre-iPSCs. Finally, Esrrb deletion abolishes the defining ability of Nanog to confer LIF-independent ESC self-renewal. These findings are consistent with the functional placement of Esrrb downstream of Nanog.
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Self-citationFunctional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
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Self-citationThe Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
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Cited by
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation
Kolodziejczyk, A. A., Kim, J. K., Tsang, J. C. H., Ilicic, T., Henriksson, J., Natarajan, K. N., Tuck, A. C., Gao, X., Bühler, M., Liu, P., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.011 · Cited by 570
Dynamic stem cell states: Naive to primed pluripotency in rodents and humans
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Epigenetics of Reprogramming to Induced Pluripotency
Papp, B., & Plath, K. (2013) · Cell · doi:10.1016/j.cell.2013.02.043 · Cited by 307
Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network
Festuccia, N., Dubois, A., Vandormael-Pournin, S., Gallego Tejeda, E., Mouren, A., Bessonnard, S., Mueller, F., Proux, C., Cohen-Tannoudji, M., & Navarro, P. (2016) · Nature Cell Biology · doi:10.1038/ncb3418 · Cited by 158
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Metadata
- Authors
- Festuccia, N., Osorno, R., Halbritter, F., Karwacki-Neisius, V., Navarro, P., Colby, D., Wong, F., Yates, A., Tomlinson, S. R., & Chambers, I.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 11
- Issue
- 4
- Pages
- 477-490
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2076612253
- Cited by
- 334
- References
- 48
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Festuccia, N., Osorno, R., Halbritter, F., Karwacki-Neisius, V., Navarro, P., Colby, D., Wong, F., Yates, A., Tomlinson, S. R., & Chambers, I. (2012). Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells. Cell Stem Cell. https://doi.org/10.1016/j.stem.2012.08.002
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