The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts
Open accessAbstract
SUMMARY Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic epigenome, particularly through demonstrations of direct lineage reprogramming of one somatic cell type to another by defined factors. However, it is not clear to what extent this type of reprogramming is able to generate fully functional differentiated cells. In addition, the activity of the reprogrammed cells in cell transplantation assays, such as those envisaged for cell-based therapy of Parkinson’s disease (PD), remains to be determined. Here we show that ectopic expression of defined transcription factors in mouse tail tip fibroblasts is sufficient to induce Pitx3 positive neurons that closely resemble midbrain dopaminergic (DA) neurons. In addition, transplantation of these induced DA (iDA) neurons alleviates symptoms in a mouse model of PD. Thus, iDA neurons generated from abundant somatic fibroblasts by direct lineage reprogramming hold promise for modeling neurodegenerative disease and for cell-based therapies of PD.
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Cites
Viable offspring derived from fetal and adult mammalian cells
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Direct conversion of fibroblasts to functional neurons by defined factors
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Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice
Zhou, H., Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.024 · Cited by 437
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons.
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Generation of pure GABAergic neurons by transcription factor programming
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Modeling psychiatric disorders at the cellular and network levels
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Metadata
- Authors
- Kim, J., Su, S. C., Wang, H., Cheng, A. W., Cassady, J. P., Lodato, M. A., Lengner, C. J., Chung, C.-Y., Dawlaty, M. M., Tsai, L.-H., & Jaenisch, R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 9
- Issue
- 5
- Pages
- 413-419
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2136243788
- Cited by
- 257
- References
- 23
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kim, J., Su, S. C., Wang, H., Cheng, A. W., Cassady, J. P., Lodato, M. A., Lengner, C. J., Chung, C.-Y., Dawlaty, M. M., Tsai, L.-H., & Jaenisch, R. (2011). Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts. Cell Stem Cell. https://doi.org/10.1016/j.stem.2011.09.011
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