Modeling psychiatric disorders at the cellular and network levels
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Although psychiatric disorders such as autism spectrum disorders, schizophrenia and bipolar disorder affect a number of brain regions and produce a complex array of clinical symptoms, basic phenotypes likely exist at the level of single neurons and simple networks. Being highly heritable, it is hypothesized that these disorders are amenable to cell-based studies in vitro. Using induced pluripotent stem cell-derived neurons and/or induced neurons from fibroblasts, limitless numbers of live human neurons can now be generated from patients with a genetic background permissive to the disease state. We predict that cell-based studies will ultimately contribute to our understanding of the initiation, progression and treatment of these psychiatric disorders.
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Using Rett syndrome as a model, neurons derived from human induced pluripotent stem cells from people with the syndrome have been found to have fewer synapses and some electrophysiological defects.
“Using Rett syndrome as a model, neurons derived from human induced pluripotent stem cells from people with the syndrome have been found to have fewer synapses and some electrophysiological defects (76).”
From Pediatric psychopharmacology: Too much or too little? (2013) · cites this paper as [76]
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- Authors
- Brennand, K. J., Simone, A., Tran, N., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Gage, F H
- Venue
- Molecular Psychiatry
- Published
- 2012-04-03
- Volume
- 17
- Issue
- 12
- Pages
- 1239-1253
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3465628
- OpenAlex
- W2003253047
- Cited by
- 119
- References
- 142
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 19 · 2015: 17 · 2014: 12 · 2013: 13 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Sanofi
- G. Harold and Leila Y. Mathers Foundation
- National Institute of Neurological Disorders and Stroke (P01NS028121)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- mental illness, autism spectrum disorder, schizophrenia, bipolar disorder, iPSC-derived neurons, induced neurons, neural network model
- MeSH terms
- Animals, Mental Disorders, Fibroblasts, Humans, Models, Neurological, Neural Pathways, Neurons, Phenotype, Induced Pluripotent Stem Cells
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