The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts
Open accessAbstract
SUMMARY Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic epigenome, particularly through demonstrations of direct lineage reprogramming of one somatic cell type to another by defined factors. However, it is not clear to what extent this type of reprogramming is able to generate fully functional differentiated cells. In addition, the activity of the reprogrammed cells in cell transplantation assays, such as those envisaged for cell-based therapy of Parkinson’s disease (PD), remains to be determined. Here we show that ectopic expression of defined transcription factors in mouse tail tip fibroblasts is sufficient to induce Pitx3 positive neurons that closely resemble midbrain dopaminergic (DA) neurons. In addition, transplantation of these induced DA (iDA) neurons alleviates symptoms in a mouse model of PD. Thus, iDA neurons generated from abundant somatic fibroblasts by direct lineage reprogramming hold promise for modeling neurodegenerative disease and for cell-based therapies of PD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Viable offspring derived from fetal and adult mammalian cells
Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J., & Campbell, K. H. S. (1997) · Nature · doi:10.1038/385810a0 · Cited by 4,969
Direct conversion of fibroblasts to functional neurons by defined factors
Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Kim, J.-H., Auerbach, J. M., Rodríguez-Gómez, J. A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S.-H., Nguyen, J., Sánchez-Pernaute, R., Bankiewicz, K., et al. (2002) · Nature · doi:10.1038/nature00900 · Cited by 1,607
Self-citationEfficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
Lee, S.-H., Lumelsky, N., Studer, L., Auerbach, J. M., & McKay, R. D. (2000) · Nature Biotechnology · doi:10.1038/76536 · Cited by 1,257
Wernig, M., Zhao, J.-P., Pruszak, J., Hedlund, E., Fu, D., Soldner, F., Broccoli, V., Constantine-Paton, M., Isacson, O., & Jaenisch, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801677105 · Cited by 1,216
Self-citationAddiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,181
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Caiazzo, M., Dell’Anno, M. T., Dvoretskova, E., Lazarevic, D., Taverna, S., Leo, D., Sotnikova, T. D., Menegon, A., Roncaglia, P., Colciago, G., et al. (2011) · Nature · doi:10.1038/nature10284 · Cited by 1,012
Direct cell reprogramming is a stochastic process amenable to acceleration
Hanna, J., Saha, K., Pando, B., van Zon, J., Lengner, C. J., Creyghton, M. P., van Oudenaarden, A., & Jaenisch, R. (2009) · Nature · doi:10.1038/nature08592 · Cited by 938
Self-citationDirect conversion of human fibroblasts to dopaminergic neurons
Pfisterer, U., Kirkeby, A., Torper, O., Wood, J., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J., & Parmar, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105135108 · Cited by 744
Direct conversion of human fibroblasts to multilineage blood progenitors
Szabo, E., Rampalli, S., Risueño, R. M., Schnerch, A., Mitchell, R., Fiebig-Comyn, A., Levadoux-Martin, M., & Bhatia, M. (2010) · Nature · doi:10.1038/nature09591 · Cited by 694
Viable Offspring Derived from Fetal And Adult Mammalian Cells
Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J., & Campbell, K. H. S. (2007) · Cloning and Stem Cells · doi:10.1089/clo.2006.0002 · Cited by 477
Fetal nigral transplantation as a therapy for Parkinson's disease
Olanow, C. W., Kordower, J. H., & Freeman, T. B. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80038-5 · Cited by 416
Fetal Nigral Transplantation as a Therapy for Parkinson’s Disease
Olanow, C. W., & Fahn, S. (2006) · Restorative Therapies in Parkinson’s Disease · doi:10.1007/0-387-32823-8_6 · Cited by 412
Mice cloned from olfactory sensory neurons
Eggan, K., Baldwin, K., Tackett, M., Osborne, J., Gogos, J., Chess, A., Axel, R., & Jaenisch, R. (2004) · Nature · doi:10.1038/nature02375 · Cited by 375
Self-citationBurden of illness in Parkinson's disease
Huse, D. M., Schulman, K., Orsini, L., Castelli‐Haley, J., Kennedy, S., & Lenhart, G. (2005) · Movement Disorders · doi:10.1002/mds.20609 · Cited by 335
Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease
Brundin, P., Nilsson, O., Strecker, R. E., Lindvall, O., Åstedt, B., & Björklund, A. (1986) · Experimental Brain Research · doi:10.1007/bf00243848 · Cited by 279
Martinat, C., Bacci, J.-J., Leete, T., Kim, J., Vanti, W. B., Newman, A. H., Cha, J. H., Gether, U., Wang, H., & Abeliovich, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511153103 · Cited by 220
Self-citationZhao, S., Maxwell, S., Jimenez‐Beristain, A., Vives, J., Kuehner, E., Zhao, J., O'Brien, C., De Felipe, C., Semina, E., & Li, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03206.x · Cited by 182
Hedlund, E., Pruszak, J., Lardaro, T., Ludwig, W. W., Viñuela, Á., Kim, K., & Ole Isacson, A. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0996 · Cited by 139
Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology
Rayport, S., Sulzer, D., Shi, W., Sawasdikosol, S., Monaco, J., Batson, D., & Rajendran, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04264.1992 · Cited by 117
Hedlund, E., Pruszak, J., Ferree, A. W., Viñuela, Á., Hong, S., Ole Isacson, A., & Kim, K. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0540 · Cited by 69
Cited by
Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.001 · Cited by 832
Ring, K. L., Tong, L. M., Balestra, M. E., Javier, R., Andrews-Zwilling, Y., Li, G., Walker, D., Zhang, W. R., Kreitzer, A. C., & Huang, Y. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.018 · Cited by 538
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice
Zhou, H., Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.024 · Cited by 437
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons.
Li, X., Zuo, X., Jing, J., Ma, Y., Wang, J., Liu, D., Zhu, J., Du, X., Xiong, L., Du, Y., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.06.003 · Cited by 428
Generation of pure GABAergic neurons by transcription factor programming
Yang, N., Chanda, S., Marro, S., Ng, Y.-H., Janas, J. A., Haag, D., Ang, C. E., Tang, Y., Flores, Q., Mall, M., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4291 · Cited by 341
Metadata
- Authors
- Kim, J., Su, S. C., Wang, H., Cheng, A. W., Cassady, J. P., Lodato, M. A., Lengner, C. J., Chung, C.-Y., Dawlaty, M. M., Tsai, L.-H., & Jaenisch, R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 9
- Issue
- 5
- Pages
- 413-419
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2136243788
- Cited by
- 257
- References
- 23
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
