The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Spermatogonial Stem Cell Transplantation into Rhesus Testes Regenerates Spermatogenesis Producing Functional Sperm
Open accessAbstract
Summary Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout a man’s life and may have application for treating some cases of male infertility, including those caused by chemotherapy before puberty. We performed autologous and allogeneic SSC transplantations into the testes of 18 adult and 5 prepubertal recipient macaques that were rendered infertile with alkylating chemotherapy. After autologous transplant, the donor genotype from lentivirus-marked SSCs was evident in the ejaculated sperm of 9/12 adult and 3/5 prepubertal recipients after they reached maturity. Allogeneic transplant led to donor-recipient chimerism in sperm from 2/6 adult recipients. Ejaculated sperm from one recipient transplanted with allogeneic donor SSCs were injected into 85 rhesus oocytes via intracytoplasmic sperm injection. Eighty-one oocytes were fertilized, producing embryos ranging from 4-cell to blastocyst with donor paternal origin confirmed in 7/81 embryos. This demonstration of functional donor spermatogenesis following SSC transplantation in primates is an important milestone for informed clinical translation.
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Hematopoietic Stem-Cell Transplantation
Copelan, E. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052638 · Cited by 2,522
Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.
Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J. L., & Deeg, H. J. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00430-s · Cited by 507
Cited by
(2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.09.013 · Cited by 753
Vermeulen, M., Del Vento, F., Kanbar, M., Pyr dit Ruys, S., Vertommen, D., Poels, J., & Wyns, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215476 · Cited by 97
Vermeulen, M., Del Vento, F., De Michele, F., Poels, J., & Wyns, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010227 · Cited by 72
Joshi, V. B., Behl, S., Pittock, S. T., Arndt, C. A. S., Zhao, Y., Khan, Z., Granberg, C. F., & Chattha, A. (2021) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2021.04.006 · Cited by 23
Metadata
- Authors
- Hermann, B. P., Sukhwani, M., Winkler, F., Pascarella, J. N., Peters, K. A., Sheng, Y., Valli, H., Rodriguez, M., Ezzelarab, M., Dargo, G., Peterson, K., Masterson, K., Ramsey, C., Ward, T., Lienesch, M., Volk, A., Cooper, D. K., Thomson, A. W., Kiss, J. E., Penedo, M. C. T., Schatten, G. P., Mitalipov, S., & Orwig, K. E.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 11
- Issue
- 5
- Pages
- 715-726
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2131717226
- Cited by
- 429
- References
- 2
- FWCI
- 28.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Spermatogonial Stem Cell Transplantation into Rhesus Testes Regenerates Spermatogenesis Producing Functional Sperm. https://app.cochat.ai/papers/10.1016/j.stem.2012.07.017
- The paper
- Hermann, B. P., Sukhwani, M., Winkler, F., Pascarella, J. N., Peters, K. A., Sheng, Y., Valli, H., Rodriguez, M., Ezzelarab, M., Dargo, G., Peterson, K., Masterson, K., Ramsey, C., Ward, T., Lienesch, M., Volk, A., Cooper, D. K., Thomson, A. W., Kiss, J. E., . . . Orwig, K. E. (2012). Spermatogonial Stem Cell Transplantation into Rhesus Testes Regenerates Spermatogenesis Producing Functional Sperm. Cell Stem Cell. https://doi.org/10.1016/j.stem.2012.07.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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