Mechanisms that Regulate Stem Cell Aging and Life Span

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Items 201–300 of 331

1. Inflammation has synergistic effect with nicotine in periodontitis by up‐regulating the expression of α7 nAChR via phosphorylated GSK‐3β
   Zhifei Zhou, Fen Liu, Lulu Wang, Bin Zhu, Yujiang Chen, Yang Yu, Xiaojing Wang · 2020 · Journal of Cellular and Molecular Medicine
2. Sirt1 Protects Subventricular Zone-Derived Neural Stem Cells from DNA Double-Strand Breaks and Contributes to Olfactory Function Maintenance in Aging Mice
   Jie Ren, Xianli Wang, Chuanming Dong, Guangming Wang, Wenjun Zhang, Chunhui Cai, Minxian Qian, Danjing Yang, Bin Ling, Ke Ning et al. · 2022 · Stem Cells
3. WHIM Syndrome-linked CXCR4 mutations drive osteoporosis
   Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau, Amélie Bonaud, Maria Kalogeraki, Antoine Boutin, Julia P. Lemos, Valéria Bisio, Joyce Koenen et al. · 2023 · Nature Communications
4. Activation of the Tor/Myc signaling axis in intestinal stem and progenitor cells affects longevity, stress resistance and metabolism in drosophila
   Olha M. Strilbytska, Uliana V. Semaniuk, Kenneth B. Storey, Bruce A. Edgar, Oleh V. Lushchak · 2016 · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology
5. Transcriptional and Cell Cycle Alterations Mark Aging of Primary Human Adipose-Derived Stem Cells
   Xiaoyin Shan, Cleresa Roberts, Eun Ji Kim, Ariana Brenner Clerkin, Gregory R. Grant, Ivona Percec · 2017 · Stem Cells
6. Postexercise essential amino acid supplementation amplifies skeletal muscle satellite cell proliferation in older men 24 hours postexercise
   Paul T. Reidy, Christopher S. Fry, Jared M. Dickinson, Micah John Drummond, Blake B. Rasmussen · 2017 · Physiological Reports
7. Generation and Characterization of Germline-Specific Autophagy and Mitochondrial Reactive Oxygen Species Reporters in Drosophila
   Kiran Suhas Nilangekar, Nidhi Murmu, Govind Sahu, Bhupendra V. Shravage · 2019 · Frontiers in Cell and Developmental Biology
8. Methods and Strategies for Procurement, Isolation, Characterization, and Assessment of Senescence of Human Mesenchymal Stem Cells from Adipose Tissue
   Meenakshi Gaur, Marek Krzysztof Dobke, Victoria V. Lunyak · 2018 · Methods in molecular biology
9. Recognition and Control of the Progression of Age-Related Hearing Loss
   Hong Ren, Jihao Ren, Wei Liu · 2013 · Rejuvenation Research
10. Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice
    Colin Selman, Amy Sinclair, Silvia M. A. Pedroni, Elaine E. Irvine, Alison M. Michie, Dominic J. Withers · 2016 · Oncotarget
11. GDF11 administration does not extend lifespan in a mouse model of premature aging
    Sandra Freitas‐Rodríguez, Francisco J. Rodríguez, Alicia R. Folgueras · 2016 · Oncotarget
12. Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging
    Xiaoxi Pan, Jiumei Cao, Fan Cai, Cheng‐Chao Ruan, Fang Wu, Pingjin Gao · 2018 · Cardiovascular Drugs and Therapy
13. Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases
    Yeojin Lee, Matthew Decker, Heather J Lee, Lei Ding · 2017 · Wiley Interdisciplinary Reviews Developmental Biology
14. Muscle stem cell aging: identifying ways to induce tissue rejuvenation
    Pedro Sousa‐Victor, Joana Neves, Pura Muñoz‐Cánoves · 2020 · Mechanisms of Ageing and Development
15. Rheb in neuronal degeneration, regeneration, and connectivity
    Veena Nambiar Potheraveedu, Miriam Schöpel, Raphael Stoll, Rolf Heumann · 2017 · Biological Chemistry
16. scAgeCom: a murine atlas of age-related changes in intercellular communication inferred with the package scDiffCom
    Cyril Lagger, Eugen Ursu, Anaïs Equey, Roberto A. Avelar, Angela Oliveira Pisco, Robi Tăcutu, João Pedro de Magalhães · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
17. Engineered Aging Cardiac Tissue Chip Model for Studying Cardiovascular Disease
    Sachin Budhathoki, Caleb Graham, Palaniappan Sethu, Ramaswamy Kannappan · 2021 · Cells Tissues Organs
18. Structural investigation of donor age effect on human bone marrow mesenchymal stem cells: FTIR spectroscopy and imaging
    Ceren Aksoy, Fatima Aerts‐Kaya, Bülent Barış Kuşkonmaz, Duygu Uçkan, Feride Severcan · 2014 · AGE
19. Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging
    Chiara de Lucia, Tytus Murphy, Sandrine Thuret · 2017 · Frontiers in Physiology
20. Nogo-A Regulates the Fate of Human Dental Pulp Stem Cells toward Osteogenic, Adipogenic, and Neurogenic Differentiation
    Chai Foong Lai, Juliet Shen, Anamaria Balic, Pierfrancesco Pagella, Martin E. Schwab, Thimios A. Mitsiadis · 2022 · Cells
21. G2 arrest primes hematopoietic stem cells for megakaryopoiesis
    Garyn, Corey M., Bover, Oriol, Murray, John W., Ma, Jing, Salas-Briceno, Karen, Ross, Susan R., Snoeck, Hans-Willem · 2024 · Cell Reports
22. Mitonuclear Communication in Stem Cell Function
    Baozhou Peng, Yaning Wang, Hongbo Zhang · 2024 · Cell Proliferation
23. dRTEL1 is Essential for the Maintenance of Germline Stem Cells
    Ying Yang, Ruiyan Kong, Feng Guang Goh, W. Gregory Somers, Gary R. Hime, Zhouhua Li, Yu Cai · 2020 · PLoS Genetics
24. Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine
    Lawrence Lum, Chuo Chen · 2015 · Current Medicinal Chemistry
25. Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity
    Infencia Xavier Raj, Won Kyun Koh, Jessica Harrison, Christine R. Zhang, Barbara Soares, Roberta Amato, Aishwarya Krishnan, David R O’Leary, Hassan Bjeije, Tyler M. Parsons et al. · 2025 · Cell stem cell
26. Why Adult Stem Cell Functionality Declines with Age? Studies from the Fruit Fly Drosophila Melanogaster Model Organism
    Oren Gonen, Hila Toledano · 2014 · Current Genomics
27. Keratinocyte stem cells are more resistant to UVA radiation than their direct progeny
    Élodie Metral, Nicolas Béchetoille, Frédéric Demarne, Odile Damour, Walid Rachidi · 2018 · PLoS ONE
28. Neural stem cells fate under neuroinflammatory conditions and oxidative stress response
    Filippo Torrisi, Simona Denaro, Jenny Ragonese, Simona D’Aprile, Agata Zappalà, Rosalba Parenti · 2025 · Frontiers in Cellular Neuroscience
29. Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long‐term hematopoiesis
    Takahiko Imai, Hiroki Tanaka, Yoko Hamazaki, Nagahiro Minato · 2019 · Cancer Science
30. Aging in chronic lung disease: Will anti-aging therapy be the key to the cure?
    Weijie Wang, Kai Zhou, Leyuan Wang, Qiuyan Qin, Huijun Liu, Ling Qin, Ming Yang, Lin Yuan, Chi Liu · 2024 · European Journal of Pharmacology
31. Dynamical analysis of cellular ageing by modeling of gene regulatory network based attractor landscape
    Ket Hing Chong, Xiaomeng Zhang, Jie Zheng · 2018 · PLoS ONE
32. S-Adenosylmethionine Metabolism and Aging
    Wil A. M. Loenen · 2017 · Elsevier eBooks
33. From Cancer to Rejuvenation: Incomplete Regeneration As the Missing Link (Part I: the Same origin, Different outcomes)
    Mamuka G. Baramiya, Eugene Baranov · 2020 · Future Science OA
34. Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A
    Wei Zhu Jin, Shaoshuai Jiang, Xinyi Liu, Yi He, Tuo Li, Jingchun Ma, Zhihong Chen, Xiaomei Lu, Xinguang Liu, Weinian Shou et al. · 2024 · Nature Communications
35. Effect of serum choice on replicative senescence in mesenchymal stromal cells
    Yang Liu, Yanqi Li, Hongyi Wang, Yanju Li, Guang-Yang Liu, Xiao Xu, Xiaobing Wu, Yong-Guang Jing, Yao Yao, Chu-Tse Wu et al. · 2015 · Cytotherapy
36. ROCK ‘n TOR: An Outlook on Keratinocyte Stem Cell Expansion in Regenerative Medicine via Protein Kinase Inhibition
    Giorgia Centonze, Sara Centonze, Luca Ponzone, Enzo Calautti · 2022 · Cells
37. Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)
    Meenakshi Gaur, Lu Wang, Alexandra Amaro-Ortiz, Marek Krzysztof Dobke, Irving King Jordan, Victoria V. Lunyak · 2017 · Journal of Stem Cell Research & Therapy
38. Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.
    Hourieh Tousian, Bibi Marjan Razavi, Hossein Hosseinzadeh · 2020 · PubMed Central
39. TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila
    Olha M. Strilbytska, Kenneth B. Storey, Oleh V. Lushchak · 2020 · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology
40. Wnt Signaling Inhibits High-Density Cell Sheet Culture Induced Mesenchymal Stromal Cell Aging by Targeting Cell Cycle Inhibitor p27
    Ying Xu, Ye Tian, Dongyi Tong, Hao Zhang, Zhengliang Luo, Xifu Shang, Yufeng Dong · 2020 · Frontiers in Bioengineering and Biotechnology
41. Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing
    Walter Fred Bodmer, Daniel J. M. Crouch · 2020 · Journal of Theoretical Biology
42. SETD4 cells contribute to brain development and maintain adult stem cell reservoir for neurogenesis
    Sun-Li Cai, Yao-Shun Yang, Yan-Fu Ding, Shuhua Yang, Xi-Zheng Jia, Yun-Wen Gu, Chris Wood, Xue-Ting Huang, Jin‐Shu Yang, Wei‐Jun Yang · 2022 · Stem Cell Reports
43. Defining the General Principles of Stem Cell Aging: Lessons from Organismal Models
    Seda Koyuncu, Dilber Irmak, Isabel Sáez, David Vı́lchez · 2015 · Current Stem Cell Reports
44. Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart
    Fayth Hui Tan, Marianne E. Bronner-Fraser · 2023 · Developmental Biology
45. Exosomal misfolded proteins released by cancer stem cells: dual functions in balancing protein homeostasis and orchestrating tumor progression
    Anuran Bhattacharya, Urmi Chatterji · 2024 · Discover Oncology
46. Insights into Bioengineering Approaches for Aging Bone Regeneration: Strategies to Target Osteoimmunosenescence
    Lan Xiao, Wendong Gao, Jinfu Wu, Itsasne Erezuma, Alireza Dolatshahi‐Pirouz, Joana Silva‐Correia, Yinghong Zhou, Antonia RuJia Sun, Indira Prasadam, Ross Crawford et al. · 2025 · Regenerative medicine and dentistry.
47. Multiparameter Characterization Confirms Apoptosis as the Primary Cause of Reduced Self-renewal Capacity in Cultured Human Fetal Neural Stem Cells
    Yunqian Guan, Xiaobo Li, Haiqiang Zou, Xiaoming Yan, Chunsong Zhao, Jiayin Wang, Ling Chen, Y.Alex Zhang · 2016 · Cellular Physiology and Biochemistry
48. Fine-tuning stemness
    Mariana Borsa, Anna Katharina Simon · 2020 · Science
49. Bmi1 – A Path to Targeting Cancer Stem Cells
    David Bakhshinyan, Ashley Adile, Chitra Venugopal, Sheila Kumari Singh · 2017 · European Oncology & Haematology
50. DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells
    Z.S. Zhang, Haiyan Yang, Lei Fang, Guangrong Zhao, Jun Xiang, Jialin Zheng, Zhao Qin · 2024 · Nature Communications
51. Can salivary and skin microbiome become a biodetector for aging-associated diseases? Current insights and future perspectives
    Fahrul Nurkolis, Trianna Wahyu Utami, Aiman Idrus Alatas, Danar Wicaksono, Rudy Kurniawan, Satria Rafi Ratmandhika, Kartika Taufani Sukarno, Yehezkiel Gian Pradipta Pahu, Bonglee Kim, Trina Ekawati Tallei et al. · 2024 · Frontiers in Aging
52. Somatic stem cell aging and malignant transformation – impact on therapeutic application
    Marcela Kuniaková, Lenka Oravcová, Zuzana Varchulová-Nováková, Diana Viglaska, Ľuboš Danišovič · 2015 · Cellular & Molecular Biology Letters
53. The non-canonical Wnt pathway leads to aged dendritic cell differentiation
    Haibo Zhou, Li Wu · 2018 · Cellular and Molecular Immunology
54. Looking for immortality: Review of phytotherapy for stem cell senescence.
    Hourieh Tousian, Bibi Marjan Razavi, Hossein Hosseinzadeh · 2020 · PubMed Central
55. Sensing Stemness
    Teresa V. Bowman, Eirini Trompouki · 2021 · Current Stem Cell Reports
56. Sirtuins in metabolic and epigenetic regulation of stem cells
    Yi Fang, Xiaoling Li · 2021 · Elsevier eBooks
57. Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis
    Xueqian Zhuang, Qing Wang, Simon Joost, Alexander Ferrena, David T. Humphreys, Zhuxuan Li, Melissa Blum, Klavdija Bastl, Selena Ding, Yuna Landais et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
58. RNA-Binding Proteins in Ageing and Age-Related Disease
    João Miguel Alves Ferreira, Сергій Тукаєв, Vaitsa Giannouli · 2026 · Neurology International
59. BCLAF1 restrains stress responses in hematopoietic stem cells to support expansion and repopulation
    Stephanie J. Crowley, Wei Yang, Lynn S. White, Jun Wu, Yanan Li, Haley A. Schmidt, Kyunghee Choi, Jeffrey A. Magee, Jeffrey J. Bednarski · 2025 · Blood Advances
60. Comparison Between SGLT2 Inhibitors and Lactation: Implications for Cardiometabolic Health in Parous Women
    María A. Ramos-Román · 2024 · Metabolic Syndrome and Related Disorders
61. Heterozygous lipoprotein lipase knockout mice exhibit impaired hematopoietic stem/progenitor cell compartment
    Guiying Shi, Xinyue Li, Keya Li, Yiying Huang, Xuepei Lei, Lin Bai, Chuan Qin · 2021 · Animal Models and Experimental Medicine
62. Noncanonical Wnt Comes of Age in Hematopoietic Stem Cells
    Evgenia V. Verovskaya, Gerald de Haan · 2013 · Cell stem cell
63. Linc-FOXD3 knockdown enhances hippocampal NSCs activation through upregulation of the Wnt/β-catenin pathway
    Haili Lang, Renjie Xiao, Ying Li, Jing Sun, Yong Chen, Yimei Lu, Junying Cai · 2020 · Neuroscience Letters
64. In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems
    Yao Yu, Zilin Zhang, Jing Zhang, Yuan Gao, Xiaoran Li, Keyu Yang, Nuo Si, Zaozao Chen, Zhongze Gu, Ningbei Yin · 2026 · Microsystems & Nanoengineering
65. A human experimental model of laminopathy based on adult stem cells establishes the relevance of Oct1 transcription factor in the aging process
    2015 · Stem Cell and Translational Investigation
66. Anti-ageing antibodies revive the immune system
    Yasar Arfat T. Kasu, Robert A. J. Signer · 2024 · Nature
67. The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of aging
    Alexander Martin Wolf · 2021
68. Hepatocyte hedgehog signaling controls ferroptosis to alleviate aging-related organ dysfunction
    Ji Hye Jun, Rajesh Kumar Dutta, Soon‐Woo Cho, Rui Yao, Seh‐Hoon Oh, Zhi Li, Kuo Du, David S. Umbaugh, Nanchao Wang, Yirui Xu et al. · 2026 · JCI Insight
69. Antiaging — Effect of Stem Cells on Aging and Stem Cell Aging
    Jisook Moon, Sang‐Hun Bae · 2015 · InTech eBooks
70. Dutch Summary — Nederlandse Samenvatting
    Evgeni Moyakine · 2017 · Intersentia eBooks
71. The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
    Bertal Huseyin Aktas, Berin Upcin, Erik Henke, Manju Padmasekar, Xuebin Qin, Süleyman Ergün · 2019 · Stem Cells International
72. Why stem/progenitor cells lose their regenerative potential
    Angela Picerno, Alessandra Stasi, Rossana Franzin, Claudia Curci, Ighli di Bari, Loreto Gesualdo, Fabio Sallustio · 2021 · World Journal of Stem Cells
73. Modifiers of Neural Stem Cells and Aging: Pulling the Trigger of a Neurogenic Decline
    Emmanuel Nivet · 2016 · Current Stem Cell Reports
74. Infiltration of old brains by T cells causes dysfunction of neural stem cells
    Allison M. Bond, Hongjun Song · 2019 · Nature
75. When wrinkles appear on the immune system can it be reversed?
    Hiba Sibaii, Salwa Refat El-Zayat, M. Khalil · 2020 · European Cytokine Network
76. Aging-induced stem cell dysfunction: Molecular mechanisms and potential therapeutic avenues
    Yander Grajeda, Nataly Arias, Albert Barrios, Shehla Pervin, Rajan Singh · 2021 · Elsevier eBooks
77. Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine
    Jiali Xiong, Lizhong Yin, Xia Li, Huiyan Wang, Bin Yu · 2025 · Aging Clinical and Experimental Research
78. Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice
    Veronica Bergo, Pavlos Bousounis, Giang To Vu, Mélodie Douté, Aikaterini Polyzou, Maria‐Eleni Lalioti, Bogdan B. Grigorash, Lyudmila Tsurkan, Nicholas Morchel, Ward Deboutte et al. · 2026 · Nature Communications
79. The Effect of Brunfelsia grandiflora Ethanol Extract on the Induction of Autophagy in Human Lung Fibroblasts
    Hyang Nam, Moon‐Moo Kim · 2014 · Journal of Life Science
80. Dynamics of osteogenesis after inoculation of autogenic mesenchymal stem cells of adipose tissue
    A S Grygoryan, A A Orlov, Irina N. Saburina, Vadim S. Repin, Sisoev Sd · 2015 · Stomatology
81. Dietary and Nutritional Regulation
    Tytus Murphy, Sandrine Thuret · 2016 · Elsevier eBooks
82. Evolutionary perspectives on cancer and aging
    Walter Fred Bodmer, Daniel J. M. Crouch · 2021 · Elsevier eBooks
83. Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging
    Helen M. Tauc, Alpaslan Tasdogan, Petra Pandur · 2014 · Journal of Visualized Experiments
84. In search of elixir: Pharmacological agents against stem cell senescence.
    Hourieh Tousian, Bibi Marjan Razavi, Hossein Hosseinzadeh · 2021 · Europe PMC (PubMed Central)
85. Aging of Epidermal Stem Cells
    Alexandra Charruyer, Ruby Ghadially · 2016 · Springer eBooks
86. Neural Precursor Cell Galvanotaxis is Conserved Across Age and is Modulated by Resting Membrane Potential
    Nancy XiaoNan Liu · 2018 · TSpace (University of Toronto)
87. Study on the Role of SIRT2 in Stem Cell Aging and Chronic Inflammation
    Hanzhi Luo · 2017 · eScholarship (California Digital Library)
88. Long‐Lived Cells and Long‐Lived Proteins in the Human Body
    Roger J.W. Truscott · 2021 · Wiley eBooks
89. Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia
    Fanny Zhou, Michelle K. Le, Helen C. Wang, Wei Yang, Huan‐You Wang, Arukshita Tiwari, Xinjian Cen, Mary Jean Sunshine, Jeffrey A. Magee, Robert A. J. Signer · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
90. Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
    Yiwen Song · 2015 · ScholarlyCommons (University of Pennsylvania)
91. Stem Cells and Organ Transplantation: Resetting Our Biological Clocks
    Henry G. Stratmann · 2015 · Science and fiction
92. The influence of ageing and culture conditions on limbal epithelial cells
    Dean Hallam · 2015
93. Aging: The Stem Cell Connection
    2013 · WORLD SCIENTIFIC eBooks
94. The aging immune system and nutritional interventions
    Adriaan A. van Beek · 2017
95. Regulation and role of miRNA and target genes in cell cycle during oxidative stress-induced premature senescence in mesenchymal stem cells
    Lihui Tai, Chiu-Jung Huang, Kong‐Bung Choo, Chee‐Yin Wong, Soon Keng Cheong, T. Tunku Zainol Abidin · 2017 · Cytotherapy
96. Reactive Oxygen Species Signaling from the Perspective of the Stem Cell
    Saghi Ghaffari, Raymond Hin-Suen Liang · 2017 · Wiley eBooks
97. Pastimes in Cancer Biology
    Charles J. Sherr · 2017 · Annual Review of Cancer Biology
98. Mobilization of Endogenous Neural Stem Cells to Promote Regeneration After Stroke
    Monika Rabenstein, Maria Adele Rueger · 2017 · Springer series in translational stroke research
99. SCIENTIFIC AND THEORETICAL VALIDATION OF DEVELOPMENT OF PERSONALIZED ANTI-CANCER CELL PREPARATION ONTHE BASES OF CLINICAL ONCOPROTEOMICS TECHNOLOGY
    Igor Bryukhovetskiy, Andrey S. Bryukhovetskiy · 2014 · Journal of clinical practice
100. The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging
     Dido Carrero, Carlos López-Otı́n · 2018 · Springer eBooks