The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells
Open accessAbstract
SUMMARY microRNAs regulate developmental cell fate decisions, tissue homeostasis and oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor microRNA miR-34a is a cell fate determinant in early stage dividing colon cancer stem cells (CCSCs). In pair-cell assays, miR34a distributes at high levels in differentiating progeny, while low levels of miR34a demarcate self renewing CCSCs. Moreover, miR34a loss of function and gain of function alters the balance between self-renewal and differentiation both in vitro and in vivo. Mechanistically, miR34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal versus differentiation. In contrast, the canonical cell fate determinant Numb regulates Notch levels in a continuously graded manner. Taken together, our findings highlight a unique microRNA regulated mechanism that converts noisy input into a toggle switch for robust cell fate decisions in CCSCs.
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692
Arrowsmith, J. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3439 · Cited by 622
MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
Ivey, K. N., & Srivastava, D. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.012 · Cited by 449
EMT is the dominant program in human colon cancer
Loboda, A., Nebozhyn, M. V., Watters, J. W., Buser, C. A., Shaw, P. M., Huang, P. S., Van't Veer, L., Tollenaar, R. A., Jackson, D. B., Agrawal, D., et al. (2011) · BMC Medical Genomics · doi:10.1186/1755-8794-4-9 · Cited by 274
Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue
Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J. C., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J., & Näthke, I. S. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.12.007 · Cited by 242 · cited 1×
“ISCs undergo both symmetric and asymmetric divisions, probably at different stages, during development and crypt homeostasis (Goulas et al., 2012; Itzkovitz et al., 2012; Potten et al., 2002; Quyn et al., 2010).”
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Mir-34: A New Weapon Against Cancer?
Misso, G., Di Martino, M. T., De Rosa, G., Farooqi, A. A., Lombardi, A., Campani, V., Zarone, M. R., Gullà, A., Tagliaferri, P., Tassone, P., et al. (2014) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2014.47 · Cited by 498
Zhang, J., Tian, X.-J., Zhang, H., Teng, Y., Li, R., Bai, F., Elankumaran, S., & Xing, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005304 · Cited by 462
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
Zeuner, A., Todaro, M., Stassi, G., & De Maria, R. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.012 · Cited by 368
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
Beumer, J., & Clevers, H. (2016) · Development · doi:10.1242/dev.133132 · Cited by 287
Emerging role of tumor cell plasticity in modifying therapeutic response
Qin, S., Jiang, J., Lu, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 268
Metadata
- Authors
- Bu, P., Chen, K.-Y., Chen, J. H., Wang, L., Walters, J., Shin, Y. J., Goerger, J. P., Sun, J., Witherspoon, M., Rakhilin, N., Li, J., Yang, H., Milsom, J., Lee, S., Zipfel, W., Jin, M. M., Gümüş, Z. H., Lipkin, S. M., & Shen, X.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 12
- Issue
- 5
- Pages
- 602-615
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1966564846
- Cited by
- 357
- References
- 6
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bu, P., Chen, K.-Y., Chen, J. H., Wang, L., Walters, J., Shin, Y. J., Goerger, J. P., Sun, J., Witherspoon, M., Rakhilin, N., Li, J., Yang, H., Milsom, J., Lee, S., Zipfel, W., Jin, M. M., Gümüş, Z. H., Lipkin, S. M., & Shen, X. (2013). A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell. https://doi.org/10.1016/j.stem.2013.03.002
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