MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
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Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.
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Small RNA pathways, especially microRNAs (miRNAs) and small interfering RNAs (siRNAs), play a vital role in regulating gene expression at transcriptional and post-transcriptional levels, influencing processes such as cell fate in eukaryotes.
“Another key epigenetic mechanism involves small RNA pathways, especially microRNAs (miRNAs) and small interfering RNAs (siRNAs), which play a vital role in regulating gene expression at both transcriptional and post-transcriptional levels, influencing essential processes such as cell fate in eukaryotes [59,60].”
From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [60]
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- Authors
- Ivey, K. N., & Srivastava, D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Srivastava, Deepak
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 7
- Issue
- 1
- Pages
- 36-41
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2171488801
- Cited by
- 449
- References
- 28
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 6 · 2023: 16 · 2022: 13 · 2021: 17 · 2020: 32 · 2019: 30 · 2018: 38 · 2017: 39 · 2016: 39 · 2015: 29 · 2014: 39 · 2013: 44 · 2012: 47
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1148 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- microRNA, cell differentiation, cell fate determination, stem cells, myogenesis, lineage specification, miRNA target genes, tissue-specific gene regulation
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Humans, Models, Biological, Cell Lineage, MicroRNAs, Embryonic Stem Cells
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