Cited by 460MicroRNA in disease regulationDevelopmental Biology and Gene RegulationMuscle Physiology and Disorders

MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

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Ivey, Kathryn N., Srivastava, Deepak·2010·Cell Stem Cell

Abstract

Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.

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Crossref · 10.1016/j.stem.2010.06.012

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  • Small RNA pathways, especially microRNAs (miRNAs) and small interfering RNAs (siRNAs), play a vital role in regulating gene expression at transcriptional and post-transcriptional levels, influencing processes such as cell fate in eukaryotes.

    “Another key epigenetic mechanism involves small RNA pathways, especially microRNAs (miRNAs) and small interfering RNAs (siRNAs), which play a vital role in regulating gene expression at both transcriptional and post-transcriptional levels, influencing essential processes such as cell fate in eukaryotes [59,60].”

    From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [60]

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Cited by

Sorted by citations

Authors
Ivey, K. N., & Srivastava, D.
Affiliations
University of California, San Francisco (US)
Corresponding author
Srivastava, Deepak
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2010-07
Volume
7
Issue
1
Pages
36-41
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W2171488801
Cited by
449
References
28
Citations by year
2026: 15 · 2025: 10 · 2024: 6 · 2023: 16 · 2022: 13 · 2021: 17 · 2020: 32 · 2019: 30 · 2018: 38 · 2017: 39 · 2016: 39 · 2015: 29 · 2014: 39 · 2013: 44 · 2012: 47
FWCI
11.89
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
microRNA, cell differentiation, cell fate determination, stem cells, myogenesis, lineage specification, miRNA target genes, tissue-specific gene regulation
MeSH terms
Animals, Cell Cycle, Cell Differentiation, Humans, Models, Biological, Cell Lineage, MicroRNAs, Embryonic Stem Cells

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