Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, Justine D., Ganat, Yosif M., Kishinevsky, Sarah, Bowman, Robert L., Liu, Becky, Tu, Edmund Y., Mandal, Pankaj K., Vera, Elsa +9 more·2013·Cell stem cell
DOI 10.1016/j.stem.2013.11.006

Cited by (783)

Items 601–700 of 783

  1. Translating Alzheimer’s disease proteomics into drug discovery opportunities
    Eleanor Drummond, Eryn L. Werry, Tomas Kavanagh, Sian Genoud, A Cho, Shihui Chen, Jonathan Du, David E. Hibbs, Michael Kassiou · 2026 · Molecular Neurodegeneration Advances
  2. Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons
    Ngo Cheung · 2026 · Cureus
  3. The system capacity view of aging and longevity
    Jing‐Dong J. Han, Lei Hou, Na Sun, Chi Xu, Joseph McDermott, Dan Wang · 2017 · Quantitative Biology
  4. Human In Vitro Models of Neuroenergetics and Neurometabolic Disturbances: Current Advances and Clinical Perspectives
    Julia Rogal, Laura Nicoleti Zamproni, Polyxeni Nikolakopoulou, Sofia Eriksson Ygberg, Anna Wedell, Anna Wredenberg, Anna Herland · 2024 · Stem Cells Translational Medicine
  5. Utility of Human Stem Cells for Drug Discovery
    Satyan Chintawar, Martin R. Graf, M. Zameel Cader · 2014 · Royal Society of Chemistry eBooks
  6. Driver or Passenger: Epigenomes in Alzheimer’s Disease
    Anke Hoffmann, Vincenza Sportelli, Michael J. Ziller, Dietmar Spengler · 2017 · Epigenomes
  7. Cell Fate Engineering Tools for iPSC Disease Modeling
    Emily K.W. Lo, Patrick Cahan · 2019 · Methods in molecular biology
  8. Human stem cell-derived microglia will be an indispensable toolbox for Alzheimer’s disease research
    Tong‐Fei Liu · 2021 · Neural Regeneration Research
  9. Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
    Alain Ndayisaba, Marcos Herrera-Vaquero, Gregor Karl Wenning, Nadia Stefanova · 2019 · Clinical Autonomic Research
  10. Enhanced maturation of human stem cell derived interneurons by mTOR activation
    Jianhua Chu, Megan L. Fitzgerald, Neha Sehgal, William Manley, Shane M. Fitzgerald, Harrison Naung, Ethan M. Goldberg, Stewart A. Anderson · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Loss of MECP2 leads to activation of p53 and neuronal senescence
    M. Ohashi, D. Allen, P. Lee, E. Korsakova, K. Fu, B. Vargas, J. Cinkornpumin, C. Salas, J. Park, I. Germanguz et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Keeping Score
    Deborah J. Sweet · 2014 · Cell stem cell
  13. Translational View on Therapeutic Strategies and Upcoming Issues: Stem Cell and Brain Organoid Approaches for Parkinson’s Disease Therapy
    Francesco Gubinelli, Jose M. Salazar, Janina Kaspar, Irene Santisteban Ortiz, Simon T. Schafer, Lena F. Burbulla · 2024 · Neuromethods
  14. From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease
    Camille Scherrer, Camille Loret, Nicolas Védrenne, Colman Buckley, Anne‐Sophie Lia, Vincent Kermène, Franck G. Sturtz, Frederic D. Favreau, Amandine M.F. Rovini, Pierre-Antoine Faye · 2025 · Journal of Tissue Engineering
  15. Biotechnology in Medicine: Fundamentals
    Manisha Nigam, Naresh Singh, Deen Bandhu Dimri, Abhay Prakash Mishra · 2025 · Interdisciplinary biotechnological advances
  16. Origin and Evolution of Induced Pluripotent Stem Cells (IPSCs)
    Alok Kumar Bandyopadhyay · 2025 · Magna Scientia Advanced Biology and Pharmacy
  17. Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research
    C Nina van der Wilt, Rogier J. A. Veltrop, Maaike H Janssens, I.B. Ivo Bakker, Francesca Stillitano, Joost P. G. Sluijter, Linda Wilhelmina Van Laake, Jolanda van der Velden, Eric Villard, Judith Montag et al. · 2025 · European Heart Journal Open
  18. Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
    Zhuoyuan Zhang, Tsering Yangzom, Ning Lü, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang · 2025 · Advanced Science
  19. The Enigma of Neuromelanin: How Animal Models Can Help Researchers to Understand the Link Between Pigments and Neurodegeneration
    Svenja Esser, Maximilian Hausherr, Katrin Marcus · 2025 · Biomedicines
  20. Modeling rare genetic skeletal disorders with bone organoids: a narrative review
    Dimitra Micha, Sandra Escalante Quirós, Elisabeth M. W. Eekhoff, Vivi Majella Heine, Jae‐Hyuck Shim, Lidiia Zhytnik · 2026 · Bone
  21. Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders
    Bingqing He, Erik Smedler · 2026 · Neuroscience Applied
  22. From Dish to Trial: Building Translational Models of ALS
    Ilias Salamotas, Sotiria Stavropoulou De Lorenzo, Aggeliki Stachtiari, Apostolos Taxiarchis, Magda Tsolaki, Iliana Michailidou, Elisavet Preza · 2026 · Cells
  23. Suppression of ATM kinase signaling accelerates cellular senescence
    Kei‐ichi Ishikawa, Takahiro Shiga, Takumi Hirose, Naoko Kuzumaki, Sakura Miyoshi, Akihiro Yamaguchi, Hidetaka Tamune, Avijite Kumer Sarkar, Kento Nakai, Kazuyoshi Baba et al. · 2026 · Stem Cell Reports
  24. Establishing causality for protein lactylation in Alzheimer’s disease: site validation, evidence standards, and experimental priorities
    Sajid Ali, Asma Ayaz, Wajid Zaman · 2026 · Biochemical Pharmacology
  25. Patient-Derived iPSCs as a Model for Schizophrenia
    Shaunna S. Berkovitch, Jonathan Iaconelli, Rakesh Karmacharya · 2015 · Enliven Journal of Stem Cell Research & Regenerative Medicine
  26. Modelling Neurodegenerative Diseases Using Human Pluripotent Stem Cells
    Vanessa Jane Hall · 2016 · InTech eBooks
  27. Pluripotent Stem Cell Banks
    Begoña Arán, Ángel Raya, Anna Veiga · 2018 · Springer eBooks
  28. Human Induced Pluripotent Stem (hiPS) Cells: Generation and Applications
    Christian M.A.H. Freund · 2020 · Learning materials in biosciences
  29. hiPSC disease modeling with 3D organoids
    Nathan James Cunningham, Rahulkumar Bhoi, Huaxiao Yang · 2022 · Elsevier eBooks
  30. The Role of MicroRNAs in Diagnosis and Treatment of Schizophrenia
    Elif Kagızman, Orçun Avşar · 2022
  31. The Brain Organoid Technology: Diversity of Protocols and Challenges
    Andrey Popatansov · 2022 · Biomedical engineering
  32. Human models as new tools for drug development and precision medicine
    Alfred K. Dei-Ampeh, Manuj M. Shah, Gerarda Cappuccio, Damian W. Young, Mirjana Maletić‐Savatić · 2022 · Elsevier eBooks
  33. The versatile applications of human pluripotent stem cell-derived microglia and microglia-containing brain organoids
    Junjiao Wu, Yu Tang · 2023 · Ageing and Neurodegenerative Diseases
  34. Partial Cell Reprogramming as a Way to Revitalize Living Systems
    Mariia Shorokhova · 2024 · Cell and Tissue Biology
  35. Induced Pluripotent Stem Cells
    Andrés M. Bratt‐Leal, Ai Zhang, Yanling Wang, Jeanne F. Loring · 2018 · Elsevier eBooks
  36. Rejuvenation on the Road to Pluripotency
    T. J. Sarkar, V. Sebastiano · 2016 · InTech eBooks
  37. Engineering of Human-Induced Pluripotent Stem Cells for Precise Disease Modeling
    Paweł Lisowski · 2018 · Springer eBooks
  38. Pluripotent Stem Cell Based Cultures to Study Key Aspects of Human Cerebral Cortex Development
    Zahra Ehsaei, Ginetta Collo, Verdon Taylor · 2018 · Institutional Research Information System (Università degli Studi di Brescia)
  39. Applications for stem cells
    Andrés M. Bratt‐Leal, Ai Zhang, Yanling Wang, Jeanne F. Loring · 2020 · Elsevier eBooks
  40. Cerebral Organoids: A Model of Brain Development
    Kirill K. Sukhinich, M. A. Aleksandrova · 2020 · Russian Journal of Developmental Biology
  41. Human Pluripotent Stem Cell-Derived Cerebellar Neurons: From Development to Modeling Cerebellar Ataxias
    Roxana Deleanu · 2021 · IntechOpen eBooks
  42. Spinocerebellar Ataxia - Concepts, Particularities and Generalities
    Patricia Bozzetto Ambrosi · 2021 · IntechOpen eBooks
  43. Axonal mRNA in human embryonic stem cell derived neurons
    Rebecca L. Bigler, Joyce W. Kamande, Raluca Dumitru, Mark Niedringhaus, Anne Marion Taylor · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
  44. TDP-43 and FUS in Amyotrophic Lateral Sclerosis: From Animal Models to Disease Mechanisms
    Sarah Y. Ebstein · 2017
  45. Huntington modeling improves with age
    Virginia B. Mattis, Clive Niels Svendsen · 2018 · Nature Neuroscience
  46. LCM-seq identifies robust markers of vulnerable and resistant human midbrain dopamine neurons
    Julio Aguila Benitez, Shangli Cheng, Nigel Kee, Ming Cao, Qiaolin Deng, Eva Hedlund · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs
    Matthew J. McCoy, Kitra Cates, Yangjian Liu, Daniel G. Abernathy, Bo Zhang, Shaopeng Liu, Paul M. Gontarz, Woo Kyung Kim, Shawei Chen, Wenjun Kong et al. · 2019 · SSRN Electronic Journal
  48. Aligning Stem Cell Models and Postmortem Studies to Query Striatal Neurodevelopment in Schizophrenia
    Kristen Brennand · 2024 · American Journal of Psychiatry
  49. Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming
    Xylena Reed, Cory A. Weller, Sara Sáez-Atiénzar, Alexandra G. Beilina, Sultana Solaiman, Makayla K. Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, Ann Zenobia Moore et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature
    Jacob H Schroader, Naa N. Adade, Emmanuel E. Adade, Mark A. Bratslavsky, Hannah K. Shorrock, Bradley R. Smith, Ting Zhou, Steven Lotz, Taylor B. Bertucci, Sally Temple et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Neuronal Cell-Cycle Re-entry Defines Divergent Outcomes Through Replication-Dependent DNA Damage in ALS
    Jonathan Plessis‐Belair, Roger B. Sher · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Mitochondria fingerprint longevity in iPSCs
    Andrea Masotti, Enrico Bertini, Claudia Compagnucci · 2015 · Oncotarget
  53. Developmental Maturation within the Hematopoietic System
    Natasha Arora · 2014 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
  54. A VAPB e a Esclerose Lateral Amiotrófica
    Melinda S. Beccari · 2016 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  55. Use of Induced Pluripotent Stem Cells in Aging Research
    Ken‐ichi Isobe · 2015 · Springer eBooks
  56. Stem cells for all ages, yet hostage to aging
    Caleb E. Finch, Andrew P. McMahon · 2016 · Stem Cell Investigation
  57. hiPSC Models Relevant to Schizophrenia
    B. Hartley, Y. Hadas, K. Brennand · 2016 · Handbook of behavioral neuroscience
  58. From Human Pluripotent Stem Cells to Peripheral Neurons
    Roxana Nat · 2016 · InTech eBooks
  59. Elucidating the contributions of genetic variants associated with addiction phenotypes
    Eileen N. Oni · 2016
  60. Stem cells in neurodegeneration: mind the gap
    Christel Claes, Joke Terryn, Catherine M. Verfaillie · 2017 · Elsevier eBooks
  61. Estudo dos efeitos da superexpressão da alfa-sinucleína sobre o tráfego mitocondrial e autofagia em leveduras, células SH-SY5Y e neurônios dopaminérgicos derivados de hiPSC de pacientes com doença de Parkinson
    Thaiany Quevedo Melo · 2017
  62. Modeling Central Nervous System Diseases Using Induced Pluripotent Stem Cells
    Xianmin Zeng, Joshua G. Hunsberger, Anton M. Simeonov, Nasir Malik, Ying Pei · 2014
  63. Induced Pluripotent Stem Cell Therapy and Safety Concerns in Age-Related Chronic Neurodegenerative Diseases
    Erden Eren, Erdoğan Pekcan Erkan, Şermin Genç, Kemal Kursad Genc · 2017 · Stem cells in clinical applications
  64. Evaluation of molecular markers in osteogenic differentiation of mesenchymal stem cells
    Felipe Augusto André Ishiy · 2017
  65. From Stem Cell Research to Three-Dimensional Organoids and Their Applications in Cancer Research: Meeting Report on the 9th International Meeting of the Stem Cell Network North Rhine Westphalia
    Samantha K. Langer, Péter Horn, Stefan Heinrichs · 2017 · Cellular Reprogramming
  66. Modeling the Brain in the Culture Dish: Advancements and Applications of Induced Pluripotent Stem‐Cell‐Derived Neurons
    Sandhya Chandrasekaran, Prashanth Rajarajan, Schahram Akbarian, Kristen Brennand · 2018 · Wiley eBooks
  67. The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging
    Dido Carrero, Carlos López-Otı́n · 2018 · Springer eBooks
  68. Transcriptional profiling of isogenic Friedreich ataxia induced pluripotent stem cell-derived neurons
    Jiun‐I Lai, Daniel C. Nachun, Lina Petrosyan, Benjamin T. Throesch, Erica Campau, Fuying Gao, Kristin K. Baldwin, Giovanni Coppola, Joel M. Gottesfeld, Elisabetta Soragni · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  69. Modelling the neurobiology of Alzheimer’s disease in vitro
    Sonia Sanz Muñoz · 2019 · Research Online (University of Wollongong)
  70. Estabelecimento de neurônios serotoninérgicos e organoides cerebrais como modelos in vitro para o estudo do Transtorno Depressivo Maior
    Yasmin Rana de Miranda Silva · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  71. THE AXONAL TRANSCRIPTOME OF HUMAN EMBRYONIC STEM CELL DERIVED NEURONS AND THE CELL AUTONOMOUS TRANSCRIPTIONAL RESPONSE TO AXON INJURY
    Rebecca L. Bigler · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  72. Disease in a Dish: Cellular Models to Understand Human Conditions
    Andrew M. Tidball · 2019 · Elsevier eBooks
  73. Modeling of Alzheimer’s Disease and Outlooks for its Therapy Using Induced Pluripotent Stem Cells
    Л. Г. Хаспеков · 2019 · Neurochemical Journal
  74. Alphabetical author order
    M. J. Cain · 2016 · Physiology News
  75. Project report: the effect of maternal low protein diet on the neuromuscular system of the offspring in mice
    Ifigeneia I. Giakoumaki · 2016 · Physiology News
  76. Obituary: Joseph Fairweather Lamb FRSE
    Jim Aiton, Eric W. Flitney, Bob Pitman, Nick Simmons · 2016 · Physiology News
  77. A Pharmacist’s take on Physiology 2015
    Hafeeza Ayuoob, Vytautas Kontrimas · 2016 · Physiology News
  78. Physiology Friday festivities at University College Cork
    John James Mackrill · 2016 · Physiology News
  79. The Journal of Physiology supports a symposium at the World Congress of Microcirculation in Kyoto, Japan
    Geraldine Frances Clough · 2016 · Physiology News
  80. Why are we still using animals to study human neurophysiology?
    Eric James Hill · 2016 · Physiology News
  81. Maureen Young: from chair to commemorative bench
    Tansey Em · 2016 · Physiology News
  82. 101 things (give or take) to do with a physiology qualification
    Martin Thomas · 2016 · Physiology News
  83. Blue Plaque at AV Hill’s former home
    David Miller · 2016 · Physiology News
  84. Trust me – I’m a scientist
    Martin Christian Michel · 2016 · Physiology News
  85. 3D Printing Primer for Physiologists
    Christof J. Schwiening · 2016 · Physiology News
  86. Dr Philip Wright leaves The Society
    Richard D. Vaughan‐Jones · 2016 · Physiology News
  87. New Council Members: Meet our latest Trustee and Affiliate members
    Guy S. Bewick, Frank Sengpiel, Holly Alice Shiels, Rachel McCormack, Matthew Piasecki · 2016 · Physiology News
  88. Analysis of catecholamine-induced beta-adrenergic signaling in TTS by patient-specific pluripotent stem cell-derived cardiomyocytes
    Celina Isabell Guessoum · 2020
  89. Thrombosis-on-a-chip
    H.J. Albers · 2020
  90. The Epigenome of Aging
    Rohini Muthuswami · 2020 · Springer eBooks
  91. Geração de um modelo de células-tronco pluripotentes humanas para estudar os mecanismos moleculares de haploinsuficiência e dominância negativa da Síndrome de Marfan
    Juliana Borsoi · 2020
  92. Modelling late-onset diseases with induced pluripotent stem cells: a matter of time management
    Charlotte Cossins, Paul Jonathan Fairchild · 2021 · Cell and Gene Therapy Insights
  93. Análise comparativa de neurônios derivados de células-tronco pluripotentes induzidas (iPSC) para avaliar a associação da Doença de Gaucher e Doença de Parkinson
    Fabiano Tófoli de Araújo · 2020
  94. Studying non–cell-autonomous neurodegeneration in Parkinson’s disease with induced pluripotent stem cells
    Tuuli-Maria Sonninen, L. M. Plotnikova, Nihay Laham-Karam, Gundars Goldsteins, Jari Koıstınaho, Šárka Lehtonen · 2021 · Elsevier eBooks
  95. Induced pluripotent stem cells as models for Amyotrophic Lateral Sclerosis
    Rivka Ofir · 2021 · Elsevier eBooks
  96. Pluripotent stem cell–derived brain-region-specific organoids
    Phuong Trang Nguyen, Hongjun Song, Guo‐li Ming · 2021 · Elsevier eBooks
  97. Biobakes contest 2015
    2016 · Physiology News
  98. Direct induction of neural cells from somatic cells
    Wado Akamatsu, Hideyuki Okano · 2020 · Elsevier eBooks
  99. Application of Stem Cells to Understanding Psychiatric Disorders
    Kristen Brennand · 2017 · Oxford University Press eBooks
  100. Lab_13 Ghana
    Anisha Tailor · 2016 · Physiology News