Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

ggplot2: Elegant Graphics for Data Analysis

Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310

Being human: The role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer's disease models

Sproul, A. A. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.06.007 · Cited by 31

Multiplication of theSNCAlocus exacerbates neuronal nuclear aging

Tagliafierro, L., Zamora, M. E., & Chiba‐Falek, O. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy355 · Cited by 30

Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's disease

Weykopf, B., Haupt, S., Jungverdorben, J., Flitsch, L. J., Hebisch, M., Liu, G., Suzuki, K., Belmonte, J. C. I., Peitz, M., Blaess, S., et al. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14345 · Cited by 30

Using induced pluripotent stem cells for modeling Parkinson’s disease

Ke, M., Chong, C., & Su, H. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i9.634 · Cited by 31

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models

Simmnacher, K., Lanfer, J., Rizo, T., Kaindl, J., & Winner, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00571 · Cited by 32

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Machiela, E., Jeloka, R., Caron, N. S., Mehta, S., Schmidt, M. E., Baddeley, H. J. E., Tom, C. M., Polturi, N., Xie, Y., Mattis, V. B., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.524369 · Cited by 27

The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models

MacDougall, G., Brown, L. Y., Kantor, B., & Chiba‐Falek, O. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.001 · Cited by 31

Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration

Fathi, A., Mathivanan, S., Kong, L., Petersen, A. J., Harder, C. R. K., Block, J., Miller, J. M., Bhattacharyya, A., Wang, D., & Zhang, S. (2021) · Aging Cell · doi:10.1111/acel.13541 · Cited by 34

Modeling axonal defects in hereditary spastic paraplegia with human pluripotent stem cells

Denton, K. R., Xu, C., Shah, H., & Li, X. J. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1416-0 · Cited by 30

Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells

Rauschert, I., Aldunate, F., Preussner, J., Arocena-Sutz, M., Peraza, V., Looso, M., Benech, J. C., & Agrelo, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175953 · Cited by 29

Modelling frontotemporal dementia using patient-derived induced pluripotent stem cells

Lines, G., Casey, J. M., Preza, E., & Wray, S. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103553 · Cited by 30

DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson’s Disease

Yazar, V., Dawson, V. L., Dawson, T. M., & Kang, S.-U. (2023) · Journal of Parkinson s Disease · doi:10.3233/jpd-223517 · Cited by 29

Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes

Lendemeijer, B., Unkel, M., Smeenk, H., Mossink, B., Hijazi, S., Gordillo-Sampedro, S., Shpak, G., Slump, D. E., van den Hout, M. C. G. N., van IJcken, W. F. J., et al. (2024) · eNeuro · doi:10.1523/eneuro.0148-24.2024 · Cited by 31

Using Stem Cells to Model Diseases of the Outer Retina

Yvon, C., Ramsden, C. M., Lane, A., Powner, M. B., da Cruz, L., Coffey, P. J., & Carr, A. F. (2015) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.05.001 · Cited by 31

Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease

Powell, S. K., Gregory, J. K., Akbarian, S., & Brennand, K. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.05.007 · Cited by 30

The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening

Gonzalez, D. M., Gregory, J. K., & Brennand, K. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00117 · Cited by 26

Stem cell‐based therapy for Parkinson’s disease with a focus on human endometrium‐derived mesenchymal stem cells

Bagheri‐Mohammadi, S., Karimian, M., Alani, B., Verdi, J., Tehrani, R. M., & Noureddini, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27182 · Cited by 28

Promoting Long‐Term Cultivation of Motor Neurons for 3D Neuromuscular Junction Formation of 3D In Vitro Using Central‐Nervous‐Tissue‐Derived Bioink

Kong, J. S., Huang, X., Choi, Y., Yi, H., Kang, J.-S., Kim, S., Kim, J., Lee, H., Rim, Y. A., Ju, J. H., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100581 · Cited by 28

Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs

Halpern, M., Brennand, K., & Gregory, J. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104562 · Cited by 30

Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations

Tripathi, U., Rosh, I., Ezer, R. B., Nayak, R., Hussein, Y., Choudhary, A., Djamus, J., Manole, A., Houlden, H., Gage, F. H., et al. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00715-0 · Cited by 34

Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders

Panchision, D. M. (2016) · Stem Cells · doi:10.1002/stem.2295 · Cited by 27

Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease

Lee, Y., Kang, J. S., Ham, O.-J., Son, M., & Lee, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.925227 · Cited by 27

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons

Bautista, C. M. C., & Sterneckert, J. L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1089970 · Cited by 27

From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease

Ho, S., Topol, A., & Brennand, K. (2015) · Biomarker Insights · doi:10.4137/bmi.s20066 · Cited by 28

Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation

Kumar, S., Curran, J. E., Glahn, D. C., & Blangero, J. (2016) · Stem Cells International · doi:10.1155/2016/2349261 · Cited by 26

Translational Prospects and Challenges in Human Induced Pluripotent Stem Cell Research in Drug Discovery

Hosoya, M., & Czysz, K. (2016) · Cells · doi:10.3390/cells5040046 · Cited by 27

Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis

Ziff, O. J., & Patani, R. (2018) · Aging Cell · doi:10.1111/acel.12862 · Cited by 27

Neurodevelopmental and synaptic defects in DNAJC6 parkinsonism, amenable to gene therapy

Abela, L., Gianfrancesco, L., Tagliatti, E., Rossignoli, G., Barwick, K. E., Zourray, C., Reid, K. M., Budinger, D., Ng, J., Counsell, J. R., et al. (2024) · Brain · doi:10.1093/brain/awae020 · Cited by 25

Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids

Barmpa, K., Saraiva, C., Lopez‐Pigozzi, D., Gomez‐Giro, G., Gabassi, E., Spitz, S., Brandauer, K., Rodriguez-Gatica, J. E., Antony, P. M. A., Robertson, G., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07273-4 · Cited by 30

Understanding Parkinson’s Disease through the Use of Cell Reprogramming

Playne, R., & Connor, B. J. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9717-5 · Cited by 28

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Jungverdorben, J., Till, A., & Brüstle, O. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1533-5 · Cited by 27

Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench

Franz, C. K., Joshi, D., Daley, E. L., Grant, R. A., Dalamagkas, K., Leung, A., Finan, J. D., & Kiskinis, E. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00572.2018 · Cited by 26

Microfluidic models of the neurovascular unit: a translational view

Wevers, N. R., & de Vries, H. E. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00490-9 · Cited by 25

Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development

Wu, H., Saito‐Diaz, K., Huang, C., McAlpine, J. L., Seo, D. E., Magruder, D. S., Ishan, M., Bergeron, H. C., Delaney, W. H., Santori, F. R., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.03.011 · Cited by 29

The FXR1 network acts as a signaling scaffold for actomyosin remodeling

Chen, X., Fansler, M. M., Janjoš, U., Ule, J., & Mayr, C. (2024) · Cell · doi:10.1016/j.cell.2024.07.015 · Cited by 26

Advances in Reprogramming-Based Study of Neurologic Disorders

Nityanandam, A., & Baldwin, K. K. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0044 · Cited by 25

Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain

López-León, M., Outeiro, T. F., & Goya, R. G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.002 · Cited by 27

High Temporal Resolution Detection of Patient-Specific Glucose Uptake from Human ex Vivo Adipose Tissue On-Chip

Zambon, A., Zoso, A., Gagliano, O., Magrofuoco, E., Fadini, G. P., Avogaro, A., D, M. F. M., Quake, S. R., & Elvassore, N. (2015) · Analytical Chemistry · doi:10.1021/ac504730r · Cited by 25

Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin

Hamilton, J., Brustovetsky, T., Sridhar, A., Pan, Y.-L., Cummins, T., Meyer, J. S., & Brustovetsky, N. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01734-2 · Cited by 22

Retinal and Brain Organoids: Bridging the Gap Between in vivo Physiology and in vitro Micro-Physiology for the Study of Alzheimer’s Diseases

Brighi, C., Cordella, F., Chiriatti, L., Soloperto, A., & Angelantonio, S. D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00655 · Cited by 25

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells

LaMarca, E. A., Powell, S. K., Akbarian, S., & Brennand, K. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00082 · Cited by 29

Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons

Cohen-Carmon, D., Sorek, M., Lerner, V., Sivaraman, D. M., Nissim‐Rafinia, M., Yarom, Y., & Meshorer, E. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01839-8 · Cited by 23

The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling

Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24

Generation of Human Neurons by microRNA-Mediated Direct Conversion of Dermal Fibroblasts

Church, V. A., Cates, K. L., Capano, L. S., Aryal, S., Kim, W. K., & Yoo, A. S. J. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1084-8_6 · Cited by 24

Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets

Ferraiuolo, L., & Maragakis, N. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135911 · Cited by 28

Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells

Winer, B. Y., Settle, A. H., Yakimov, A. M., Jeronimo, C., Lazarov, T., Tipping, M. J., Saoi, M., Sawh-Gopal, A., Sepp, A.-L. L., Galiano, M., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adl2388 · Cited by 26

The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside

Xie, N., & Tang, B. (2016) · Stem Cells International · doi:10.1155/2016/6484713 · Cited by 25

Concise Review: Human Induced Pluripotent Stem Cell Models of Retinitis Pigmentosa

Artero‐Castro, A., Lukovic, D., Jendelová, P., & Erceg, S. (2018) · Stem Cells · doi:10.1002/stem.2783 · Cited by 25

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson–Gilford progeria (HGPS)

Dreesen, O. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190882 · Cited by 28

Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons

Shum, C., Macedo, S. C., Warre-Cornish, K. M., Cocks, G. D., Price, J., & Srivastava, D. P. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.014 · Cited by 24

Stem cells for amyotrophic lateral sclerosis modeling and therapy: Myth or fact?

Coatti, G. C., Beccari, M. S., Olávio, T. R., Mitne‐Neto, M., Okamoto, O. K., & Zatz, M. (2015) · Cytometry Part A · doi:10.1002/cyto.a.22630 · Cited by 23

Mutant PRPF8 Causes Widespread Splicing Changes in Spliceosome Components in Retinitis Pigmentosa Patient iPSC-Derived RPE Cells

Arzalluz-Luque, Á., Cabrera, J. L., Skottman, H., Benguría, A., Bolinches-Amorós, A., Cuenca, N., Lupo, V., Dopazo, A., Tarazona, S., Delás, B., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.636969 · Cited by 26

Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate

Thiry, L., Clément, J.-P., Haag, R., Kennedy, T. E., & Stifani, S. (2022) · ASN NEURO · doi:10.1177/17590914211073381 · Cited by 26

Transcriptome Profiling Reveals Degree of Variability in Induced Pluripotent Stem Cell Lines: Impact for Human Disease Modeling

Schuster, J., Halvardson, J., Lorenzo, L. P. E., Ameur, A., Sobol, M., Raykova, D., Annerén, G., Feuk, L., & Dahl, N. (2015) · Cellular Reprogramming · doi:10.1089/cell.2015.0009 · Cited by 22

The effect of age on stem cell function and utility for therapy

Narbonne, P. (2018) · Cell Medicine · doi:10.1177/2155179018773756 · Cited by 26

VPS35 and retromer dysfunction in Parkinson's disease

Rowlands, J., & Moore, D. J. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0384 · Cited by 24

An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier

Lall, D., Workman, M. J., Sances, S., Ondatje, B. N., Bell, S., Lawless, G. M., Woodbury, A., West, D., Meyer, A. S., Matlock, A. D., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.05.015 · Cited by 24

Human stem cell models of dementia

Livesey, F. J. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu302 · Cited by 22

One Step Into the Future: New iPSC Tools to Advance Research in Parkinson’s Disease and Neurological Disorders

Mohamed, N., Larroquette, F., Beitel, L. K., Fon, E. A., & Durcan, T. M. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-181515 · Cited by 23

The iNs and Outs of Direct Reprogramming to Induced Neurons

Carter, J., Halmai, J. A. N. M., & Fink, K. D. (2020) · Frontiers in Genome Editing · doi:10.3389/fgeed.2020.00007 · Cited by 21

Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening

Ma, C., Seong, H., Li, X., Yu, X., Xu, S., & Li, Y. (2022) · Stem Cells International · doi:10.1155/2022/2150680 · Cited by 25

Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities

Wang, X. M., Yik, W. Y., Zhang, P., Lu, W., Huang, N., Kim, B. R., Shibata, D. K., Zitting, M., Chow, R. H.-P., Moser, A. B., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0149-3 · Cited by 22

Concise Review: Modeling Central Nervous System Diseases Using Induced Pluripotent Stem Cells

Zeng, X., Hunsberger, J. G., Simeonov, A. M., Malik, N., Pei, Y., & Rao, M. S. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0102 · Cited by 24

Electrical maturation of neurons derived from human embryonic stem cells

Telias, M., Segal, M., & Ben‐Yosef, D. (2014) · F1000Research · doi:10.12688/f1000research.4943.1 · Cited by 22

Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

Jiménez-Moreno, N., Stathakos, P., Caldwell, M. A., & Lane, J. D. (2017) · Cells · doi:10.3390/cells6030024 · Cited by 22

Oxidative DNA Damage Signalling in Neural Stem Cells in Alzheimer’s Disease

Kieroń, M., Żekanowski, C., Falk, A., & Wężyk, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2149812 · Cited by 22

Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

Hicks, E. M., Seah, C., Cote, A. C., Marchese, S., Brennand, K., Nestler, E. J., Girgenti, M. J., & Huckins, L. M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02412-7 · Cited by 21

Retinal organoids in disease modeling and drug discovery: Opportunities and challenges

Chakrabarty, K., Nayak, D., Debnath, J., Das, D., Shetty, R., & Ghosh, A. (2023) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2023.09.003 · Cited by 20

Human neurons to model aging: A dish best served old

Böhnke, L., Traxler, L., Herdy, J. R., & Mertens, J. (2018) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2019.01.001 · Cited by 23

Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research

Premeaux, T. A., Mediouni, S., Léda, A. R., O’Brien, R. L. F., Valente, S. T., Fine, H. A., Nixon, D. F., & Ndhlovu, L. C. (2021) · mBio · doi:10.1128/mbio.00680-21 · Cited by 22

A functional aged human iPSC‐cortical neuron model recapitulates Alzheimer's disease, senescence, and the response to therapeutics

Gallo, L. H., Akanda, N., Autar, K., Patel, A., Cox, I. M., Powell, H. A., Grillo, M., Barakat, N. M., Morgan, D., Guo, X., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14044 · Cited by 22

Suitability and limitations of mesenchymal stem cells to elucidate human bone illness

Mitxitorena, I., Infante, A., Gener, B., & Rodríguez, C. I. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i9.578 · Cited by 20

Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease

Móvio, M. I., de Lima-Vasconcellos, T. H., dos Santos, G. B., Echeverry, M. B., Colombo, E., Mattos, L. S., Resende, R. R., & Kihara, A. H. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.09.011 · Cited by 21

Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models

Magni, M., Bossi, B., Conforti, P., Galimberti, M., Dezi, F., Lischetti, T., He, X., Barker, R., Zuccato, C., Espuny-Camacho, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113159 · Cited by 22

Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology

Cvekl, A., & Camerino, M. J. (2022) · Cells · doi:10.3390/cells11213516 · Cited by 24

Aging phenotype in AD brain organoids: Track to success and challenges

Hossain, M. K., Kim, H., & Chae, H. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102256 · Cited by 25

Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead

Freude, K., Pires, C., Hyttel, P., & Hall, V. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041402 · Cited by 21

Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy

Seranova, E., Palhegyi, A. M., Verma, S., Dimova, S., Lasry, R., Naama, M., Sun, C., Barrett, T. G., Rosenstock, T. R., Kumar, D., et al. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.024 · Cited by 20

Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges

Seah, S., Farran, C. A. E., Warrier, T., Xu, J., & Loh, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226119 · Cited by 21

The crosstalk between cellular reprogramming and senescence in aging and regeneration

Chiche, A., Chen, C., & Li, H. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111005 · Cited by 21

Progress and potential of brain organoids in epilepsy research

Brown, R., Rabeling, A., & Goolam, M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03944-5 · Cited by 19

Sendai Virus-Based Reprogramming of Mesenchymal Stromal/Stem Cells from Umbilical Cord Wharton’s Jelly into Induced Pluripotent Stem Cells

Miere, C., Devito, L., & Ilić, D. (2014) · Methods in molecular biology · doi:10.1007/7651_2014_163 · Cited by 19

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