Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

Miller, Justine D., Ganat, Yosif M., Kishinevsky, Sarah, Bowman, Robert L., Liu, Becky, Tu, Edmund Y., Mandal, Pankaj K., Vera, Elsa, Shim, Jae-won, Kriks, Sonja, Taldone, Tony, Fusaki, Noemi, Tomishima, Mark J., Krainc, Dimitri, Milner, Teresa A., Rossi, Derrick J., Studer, Lorenz·2013·Cell stem cell

DOI 10.1016/j.stem.2013.11.006

Cited by (781)

Items 401–500 of 781

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Takaharu Negoro, Hanayuki Okura, Akifumi Matsuyama · 2017 · BioResearch open access
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Justine D. Miller, Lorenz Studer · 2014 · Aging
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Hailey Pineau, Valerie L. Sim · 2021 · Biomolecules
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Brodie Fischbacher, Sarita Hedaya, Brigham J. Hartley, Zhongwei Wang, Gregory Lallos, Dillion Hutson, Matthew Zimmer, Jacob Brammer, The NYSCF Global Stem Cell Array Team,, Daniel J Paull · 2021 · Nature Machine Intelligence
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Alexandru M. Pleşa, Michael Shadpour, Edward S. Boyden, George McDonald Church · 2023 · Human Genetics
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Laura R. Bramwell, Lorna W. Harries · 2023 · GeroScience
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Vorapin Chinchalongporn, Peter Koppensteiner, Deborah Prè, Wipawan Thangnipon, Leonilda Bilo, Ottavio Arancio · 2015 · Alzheimer s Research & Therapy
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Dmitry A. Ovchinnikov, Ernst Jurgen Wolvetang · 2014 · Journal of Clinical Medicine
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Jeffrey R. Jones, Su‐Chun Zhang · 2016 · Current Opinion in Biotechnology
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Mengmeng Jin, Mahabub Maraj Alam, Alice Y.‐C. Liu, Peng Jiang · 2022 · Stem Cell Reports
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Shao Hua Yang, Shiri Procaccia, Hea-Jin Jung, Chika Nobumori, Angelica Tatar, Yiping Tu, Yulia R. Bayguinov, Sung Jin Hwang, Deanna Tran, Sean M. Ward et al. · 2015 · Human Molecular Genetics
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Acosta Ingram, Diana, Turkes, Emir, Kim, Tae Yeon, Vo, Sheeny, Sweeney, Nicholas, Bonte, Marie-Amandine, Rutherford, Ryan, Julian, Dominic L., Pan, Meixia, Marsh, Jacob et al. · 2025 · Nature Communications
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Lyle Armstrong, Jumana Yousuf Al-Aama, Miodrag Stojković, Majlinda Lako · 2014 · Stem Cells
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Claudia A. Doege, Asa Abeliovich · 2014 · Biological Psychiatry
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E. M Samoylova, Vladimir P. Baklaushev · 2020 · Biochemistry (Moscow)
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Jonathan Li, Ernest Fraenkel · 2021 · Annual Review of Biomedical Data Science
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Rubika Balendra, Rickie Patani · 2016 · World Journal of Methodology
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Lauren N. Randolph, Yuqian Jiang, Xiaojun Lance Lian, § These authors contributed equally. · 2017 · AIMS Cell and Tissue Engineering
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Anna Maria Schreiber, Julia Oliwia Misiorek, Jill S. Napierala, Марек Напиерала · 2018 · Expert Opinion on Orphan Drugs
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Johanna Kaindl, Beate Winner · 2019 · Current topics in behavioral neurosciences
Identifying Age‐Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age
Chao Zhang, Nathalie G. Saurat, Daniela Cornacchia, Sun Young Chung, Trisha Sikder, Adrianne Nemchik, Andrew P. Minotti, Lorenz Studer, Doron Betel · 2025 · Aging Cell
Review: Induced pluripotent stem cell models of frontotemporal dementia
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Ilaria Bellantuono, Heather Mortiboys, Emily M. Rocha, Manish Chamoli, Shankar J. Chinta, Julie Kay Andersen, Ruby Wallis, Erwan Bézard, Matt Goldberg, Tim Greenamyre et al. · 2023
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Sa Cai, Ying-Shing Chan, Daisy Kwok-Yan Shum · 2014 · PubMed
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