The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth
Open accessAbstract
Summary Stem-like glioma cells reside within a perivascular niche and display hallmark radiation resistance. Understanding of the mechanisms underlying these properties will be vital for the development of effective therapies. Here we show that the stem cell marker CD44 promotes cancer stem cell phenotypes and radiation resistance. In a mouse model of glioma, Cd44−/− and Cd44+/− animals showed improved survival compared to controls. The CD44 ligand Osteopontin shared a perivascular expression pattern with CD44 and promoted glioma stem cell-like phenotypes. These effects were mediated via the γ-secretase regulated intracellular domain of CD44, which promoted aggressive glioma growth in vivo and stem cell-like phenotypes via CBP/p300-dependent enhancement of HIF-2α activity. In human glioblastoma multiforme, expression of CD44 correlated with hypoxia-induced gene signatures and poor survival. Together, these data suggest that in the glioma perivascular niche, Osteopontin promotes stem cell-like properties and radiation resistance in adjacent tumor cells via activation of CD44 signaling.
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Cites
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m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
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The biology and role of CD44 in cancer progression: Therapeutic implications
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Extracellular matrix and its therapeutic potential for cancer treatment
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Advances in the molecular genetics of gliomas — implications for classification and therapy
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Metadata
- Authors
- Pietras, A., Katz, A. M., Ekström, E. J., Wee, B., Halliday, J. J., Pitter, K. L., Werbeck, J. L., Amankulor, N. M., Huse, J. T., & Holland, E. C.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 14
- Issue
- 3
- Pages
- 357-369
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1985323012
- Cited by
- 540
- References
- 11
- FWCI
- 20.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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