Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

Hogan, Brigid L.M., Barkauskas, Christina E., Chapman, Harold A., Epstein, Jonathan A., Jain, Rajan, Hsia, Connie C.W., Niklason, Laura, Calle, Elizabeth +10 more·2014·Cell Stem Cell
DOI 10.1016/j.stem.2014.07.012

Cited by (879)

Items 801–879 of 879

  1. On The Functional Dynamics of Alveolar and Ductal Growth in The Adolescent Lung
    Rex A. Moats, David S. Koos, Wei Shi, Yang Hang Tang, Harvey A. Pollack, Dnyanesh N. Tipre, Thien Khuu, Vlad Larionov, Clarence M. Wigfall, Merryn Howatson Tawhai et al. · 2021 · Research Square
  2. Proteins in cord blood as a new target for prevention and treatment of bronchopulmonary dysplasia: a proteomic analysis
    Juan Wang, Jianping Mao, Gang Chen, Yuanmei Huang, Jin-Jin. Zhou, Changlong Gao, Jun Sun · 2021 · Research Square
  3. Isolation, ‘omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells
    Huaibiao Li, Moritz Schütte, Magdalena Bober, Torsten C. Kroll, Lucien Frappart, Ghina Bou About, Yu‐Chieh Lin, Tania Sorg, Yann Hérault, Christoph Wierling et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Novel therapeutic strategies for idiopathic pulmonary fibrosis: targeting epithelial repair and regeneration
    Leo Baalman · 2021
  5. Effects of Aging and Associated Conditions on Humoral Responses to Respiratory Tract Infections
    Daniela Frasca · 2021 · Healthy ageing and longevity
  6. Single-cell RNA-seq analysis reveals lung epithelial cell-specific contributions of Tet1 to allergic inflammation
    Tao Zhu, Anthony P. C. Brown, Lucy P. Cai, Gerald Quon, Hong Ji · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Hypercapnia limits β-catenin-mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts
    Laura A. Dada, Lynn C. Welch, Natalia Magnani, Ziyou Ren, Patricia L. Brazee, Diego A. Celli, Annette S. Flozak, Anthea Weng, Mariana Maciel, Vitalii Kryvenko et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Interaction Between Epithelial and Mesenchymal Cells in Interstitial Lung Disease
    Max Cohen, Paul J. Wolters · 2020 · Elsevier eBooks
  9. Lung Organoid: Innovative Technology for Respiratory Disease Modelling
    Nur Shuhaidatul Sarmiza Abdul Halim, Syahidatul Amali Che Shaffie, Mohd Nor Azim Ab Patar, Badrul Hisham Yahaya · 2022 · Stem cell biology and regenerative medicine
  10. Lung Organoids: A New Pathway into Lung Regeneration and Repair
    Lu Tian, Chennan Carrie Zhang, Martha Rea-Moreno, Ya‐Wen Chen · 2022 · Stem cell biology and regenerative medicine
  11. Vascular niche-mediated contributions to organ regeneration and fibrosis
    Yutian Chen, Bi‐Sen Ding · 2022 · Scientia Sinica Vitae
  12. Funktionen von Trp53 in der Homöostase des Bronchialepithels und der Kontrolle pulmonaler Entzündungsreaktionen als modellhafte Perspektive auf die COPD
    Jan Michael Scharte · 2021
  13. Vasculogenesis, Angiogenesis and Lung Alveolar Development
    Tadanori Mammoto, Akiko Mammoto · 2020 · Elsevier eBooks
  14. Faculty Opinions recommendation of Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer.
    Alejandro A. Schäffer · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  15. Faculty Opinions recommendation of Allergic inflammatory memory in human respiratory epithelial progenitor cells.
    Graham Stuart Ogg · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  16. Spatiotemporal coordination of stem cell behavior following alveolar injury
    Maurizio Chioccioli, Sumner Magruder, John E. McDonough, Jessica Nouws, Tao Yang, David G. Gonzalez, Lucia Borriello, Brian C. Traub, Xianjun Ye, Caroline Hendry et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Targeting the COPD lung microenvironment for lung repair: mechanisms and novel therapeutic opportunities
    Chiara Ciminieri · 2023
  18. Somatic mutations in chronic lung disease are associated with reduced lung function
    Jeong Hyun Yun, M.A. Wasay Khan, Auyon Ghosh, Brian D. Hobbs, Peter J. Castaldi, Craig P. Hersh, Peter Grant Miller, Carlyne D. Cool, Frank C. Sciurba, Lucas Barwick et al. · 2023 · medRxiv
  19. ГІСТОГЕНЕЗ РАКУ ЛЕГЕНІ - ЕТАПИ ДОСЛІДЖЕННЯ
    Болгова Лидия Севастьяновна, Т. М. Туганова Т. М. Туганова, Olga Ivanovna Alekseenko, А. О. Пономаренко, V D Zakharychev · 2023 · Medical Informatics and Engineering
  20. NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER
    Болгова Лидия Севастьяновна, Анатолий Федорович Шипко, T.N. Tuganova, Olga Ivanovna Alekseenko, Ivan Ivanovich Smolanka, А. А. Пономаренко, Nadiia Bilko · 2023 · Experimental Oncology
  21. Methods and techniques for lung cancer detection, diagnosis, and treatment
    Ilma Meša · 2022 · Bioengineering Studies
  22. [Research Progress on the Protective Effect of Intestinal Flora on Radiation-induced Lung Injury in Thoracic Tumors].
    Guohui Liu, E Mingyan · 2023 · PubMed Central
  23. Development of the Avian Respiratory System
    John Ndegwa Maina · 2023 · Zoological monographs
  24. Breathing life into in vitro models
    Danielle Baptista · 2023
  25. Морфологічні дослідження у визначенні гістогенезу раку легень
    2023 · Clinical Oncology
  26. SOX9-regulated matrix proteins predict poor outcomes in patients with COVID-19 and pulmonary fibrosis
    Laurence Pearmain, Elliot J. Jokl, Kara Simpson, Lindsay Birchall, Yaqing Ou, Craig Lawless, Angela Simpson, L Mann, Nicholas A. Scott, Rajesh D. Shah et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Adoptively Transferred Myeloid-Derived Suppressor Cells Decrease Influenza A Virus Infection Mortality in a Mouse Model
    Zhiqi Xie, Atsushi Kawai, Nobumasa Watanabe, Naoki Okada, Yasuo Yoshioka, Masashi Tachibana · 2024 · BPB Reports
  28. Additional file 6 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Jianhui Sun, Huacai Zhang, Di Liu, Wenyi Liu, Juan Du, Dalin Wen, Luoxi Li, Anqiang Zhang, Jianxin Jiang, Ling Zeng · 2023 · Figshare
  29. Additional file 7 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Jianhui Sun, Huacai Zhang, Di Liu, Wenyi Liu, Juan Du, Dalin Wen, Luoxi Li, Anqiang Zhang, Jianxin Jiang, Ling Zeng · 2023 · Figshare
  30. Yoğun Bakımda Tanı ve Tedavi
    E. Gülhan Gölcükcü Aydın, Erhan Durceylan, Yavuz Selim Angın, Gizem Basyazici, Emre Özkara, Aytek Hüseyin Çeliksöz, Ezgi Yılmaz, Ali Rıza Ata, Muhittin Akarsu, Ayşegül ÇINAROĞLU et al. · 2024 · Akademisyen Kitabevi eBooks
  31. Cellular response in the pathogenesis of COVID-19
    Lokesh Sharma, Jooyoung Kim, Charles S. Dela Cruz · 2024 · European Respiratory Society eBooks
  32. A Single-Cell Atlas of the Upper Respiratory Epithelium Reveals Heterogeneity in Cell Types and Patterning Strategies
    Alexander G. Foote, Xin Sun · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Co-colonization and Co-culture of Lung Alveoli Epithelial Stem Cells and Their Endothelial Niche Cells
    Hiroyuki Hirai, Qian Chen, Yuru Liu · 2025 · Methods in molecular biology
  34. Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function
    Pavan Prabhala, Sofia Freiman, Nika Gvazava, Jiten Sharma, Sofia C. Wijk, Karina Kanzenbach, Stefan Lang, Rebecka Cattani, Jenny Wigén, David Bryder et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  35. The Value of Nuclear Diameter in the Differential Diagnosis of Pulmonary Lesions and Lung Adenocarcinoma
    越 白 · 2025 · Journal of Clinical Personalized Medicine
  36. miR-10a-5p inhibits cardiac fibrosis by targeting the MRTF-A/TGF-β2 feedback loop
    Chen Liu, Jinhua Ding, Xiaojie Chen, Fan Zhang, Ying Wang, Hongpeng He, Xing‐Hua Liao, Tongcun Zhang, Xuejun Ren, Nan Wang · 2025 · Cellular Signalling
  37. Dynamic Culture Improves the Predictive Power of Bronchial and Alveolar Airway Models of SARS-CoV-2 Infection
    Claire H Caygill, Rose C. Lopeman, Kirstie A Lewis, Emily Richardson, Aitor Casas-Sánchez, Nick Heavey, Adam Winrow, Louise Howard, Chris Williams, Dominic Wooding et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Role of Pulmonary Neuroendocrine Cells in COPD
    Lulu Zhang, Bo Tu, Qingliang Xue · 2025 · Immunological Investigations
  39. Epithelial Cell Damage and Cell Renewal in the Lung
    Laura S. Van Winkle, Sarah A. Carratt · 2018 · Elsevier eBooks
  40. Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures
    Rinu Sivarajan, Paul C. Kirchgatterer, Jan Lawrenz, Eszter Tanner-Matiz, Jessica Lindenmayer, Verena Renz, Tapan Joshi, Heike Oberwinkler, Thorsten Walles, Giorgio Fois et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Additional file 4 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  42. Additional file 5 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  43. Additional file 1 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Jianhui Sun, Huacai Zhang, Di Liu, Liu, Wenyi, Du, Juan, Wen, Dalin, Li, Luoxi, Anqiang Zhang, Jiang, Jianxin, Zeng, Ling · 2023 · Figshare
  44. Additional file 5 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Sun, Jianhui, Huacai Zhang, Liu, Di, Liu, Wenyi, Du, Juan, Wen, Dalin, Li, Luoxi, Anqiang Zhang, Jiang, Jianxin, Zeng, Ling · 2023 · Figshare
  45. Additional file 7 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  46. Additional file 1 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  47. Additional file 3 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Jianhui Sun, Huacai Zhang, Di Liu, Liu, Wenyi, Du, Juan, Wen, Dalin, Li, Luoxi, Anqiang Zhang, Jiang, Jianxin, Zeng, Ling · 2023 · Figshare
  48. Additional file 8 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  49. Additional file 1 of Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes
    Zhang, Xiang, Xinxin Hu, Zhang, Yuqing, Bin Liu, Pan Haihong, Zikai Liu, Zhuomeng Yao, Zhu, Qixing, Changhao Wu, Tong Shen · 2024 · Figshare
  50. Additional file 1 of Culture and expansion of murine proximal airway basal stem cells
    Wu, Meirong, Zhang, Xiaojing, Yanjuan Tu, Cheng, Wenzhao, Zeng, Yiming · 2024 · Figshare
  51. Additional file 2 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Jianhui Sun, Huacai Zhang, Di Liu, Liu, Wenyi, Du, Juan, Wen, Dalin, Li, Luoxi, Anqiang Zhang, Jiang, Jianxin, Zeng, Ling · 2023 · Figshare
  52. Additional file 2 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  53. Additional file 1 of Quercetin improves epithelial regeneration from airway basal cells of COPD patients
    Elizabeth McCluskey, Nathan Liu, Abhimaneu Pandey, Marchetti, Nathaniel, Steven G. Kelsen, Sajjan, Umadevi S. · 2024 · Figshare
  54. Additional file 2 of Extracellular matrix stiffness mediates uterine repair via the Rap1a/ARHGAP35/RhoA/F-actin/YAP axis
    Zhang, Tao, Hu, Ruiting, Wang, Yan, Guo, Shuai, Wu, Zhimin, Liu, Junfeng, Han, Chunyang, Changwei Qiu, Deng, Ganzhen · 2024 · Figshare
  55. Additional file 3 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  56. Additional file 4 of CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
    Sun, Jianhui, Huacai Zhang, Liu, Di, Liu, Wenyi, Du, Juan, Wen, Dalin, Li, Luoxi, Anqiang Zhang, Jiang, Jianxin, Zeng, Ling · 2023 · Figshare
  57. Additional file 6 of Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm
    Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Zhang, Tianci, Li, Pan, Fang He, Li, Nengzhang, Peng, Yuanyi · 2024 · Figshare
  58. Caveolin-1 modulates Notch transcriptional activity during in vitro respiratory multiciliated cell maturation
    Marcos Olivera-Gómez, Guadalupe Cumplido-Laso, Dixan A. Benitez, Juan Francisco Barrera-López, Nuria Del Valle-Del Pino, Alba Díaz-Pizarro, Mónica Toledano-Donado, Mauro Català-Montoro, Sonia Mulero‐Navarro, Ángel Román et al. · 2026 · Scientific Reports
  59. Epigenetic Scarring and a Vulnerable Mucus–Barrier Axis in Ex‐Smokers With COPD
    Mitsuo Sato · 2026 · Respirology
  60. Plasminogen Activator Inhibitor 1, Cell Senescence, and Aging-Related Diseases
    Rui-Ming Liu, Mary F. Nakamya · 2026 · Cells
  61. Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs
    Minkyu Lee, Xin Wang, Qihua Ye, George X. Huang, Michael V Mandanas, Nils R. Hallen, Laura Cho, Joshua A. Boyce, Tanya M. Laidlaw, Nora A. Barrett · 2026 · Nature Communications
  62. A postnatal human lung developmental atlas reveals windows of genetic vulnerability to chronic lung disease
    Joseph D. Planer, Michael P. Morley, Songlin Cai, Andrew R. Peterson, MinQi Lu, Yifan Yang, Hannah Hallquist, Sarah E. Schaefer, Justine Carl, Su Zhou et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Highly regional generation and heterogeneous differentiation of basal cells in mouse trachea
    Xiuxiu Liu, Wendong Weng, Zhen He, Kuo Liu, Maoying Han, Wenjuan Pu, Bin Zhou · 2026 · Cell Discovery
  64. Catching cellular heterogeneity and differentiation dynamics of normal and pathological airway epithelia through single cell transcriptional profiling
    Sandra Ruiz García · 2018 · theses.fr (ABES)
  65. Analysis of single cell gene expression reveals cellular heterogeneity and differentiation dynamics of an healthy airway epithelia
    Marie Deprez · 2019 · theses.fr (ABES)
  66. Suppressing p16INK4a promotes lung regeneration through a fibroblast lipogenic switch
    M. Zysman · 2019
  67. Contribution des gènes des loci 5q11 et 11q23 à la multiciliogenèse et régulation de l’équilibre mucociliaire de l’épithélium des voies respiratoires au cours de la régénération in vitro
    Amélie Cavard · 2020 · theses.fr (ABES)
  68. Lung responses to radiation injury at the single cell level
    Sandra Curras-Alonso · 2021
  69. Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c + Basal Cells in Severe Lung Injury
    Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan et al. · 2026 · Advanced Science
  70. Autologous airway basal cell transplantation for destroyed lung repair
    Qi Zheng, Y S Bai, Xiaohua Gu, Zhanxia Li, Zhongliang Guo, Qinghua Liu, J F Xu, Ying xi, Chenwen Huang, Tao Ren · 2026 · Translational research
  71. Emerging therapeutic potential of umbilical cord-derived extracellular vesicles in lung-injurious diseases: a review of recent advances
    Shuzhe Xiao, Lingling Wang, Li Xu, Qi Zheng, Lewen Zhou, Xiaoyan Song, Jie Yang · 2026 · Stem Cell Research & Therapy
  72. Human club cells derived from pluripotent stem cells reveal new insights into epithelial lineage plasticity through structural and functional validation
    Naoyuki Sone, Naoki Fujiwara, Abeer Keshta, Satoshi Konishi, Manabu Toyoshima, Tomoyuki Takaku, Yasuhiko Takahashi, Mio Iwasaki, Takuya Yamamoto, Shimpei Gotoh · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  73. NADPH Oxidases and Pulmonary Fibrosis
    B. Deskin, Victor John Thannickal · 2026 · Springer eBooks
  74. Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression
    Aneta Pankow, Xiao-Hong Sun · 2026 · The Journal of Immunology
  75. RELMα establishes a permissive environment for influenza virus infection through direct effects on lung epithelial cells
    Roksana Shirazi, Sang Yong Kim, Aaron Cruz, James P. Stumpff, Stefanie Sveiven, Sumaya Troy Alaama, Jennell Jennett, Brandon H. Le, Meera Goh Nair, Juliet M. Morrison · 2026 · Journal of Virology
  76. Advances and challenges in cell-based therapy for lung diseases
    Daniel J. Wallman, Venicia Alhawach, Finn J Hawkins, Thomas J. Lynch · 2026 · Cytotherapy
  77. A tonic PDGFA-dependent niche organizer maintains alveolar homeostasis
    Rebecca A. Shelley, Arvind Konkimalla, Thomas J. Whitlow, Kyoshiro Tsuge, Shuyu Liu, Michael T. Forrester, Aleksandra Tata, Purushothama Rao Tata · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  78. Cell-Type-Specific Effects of IGF-1, KGF, and GHRH on Pulmonary Endothelial Wound Repair and Epithelial Monolayer Growth
    Johnny Zhu, Arwen Fu, Shenggang Yan, Phu Nguyen, Linda Shi, Veronica Gomez‐Godinez · 2026 · Journal of Biomedical Engineering and Biosciences
  79. Ethmoidal sinus scRNA from CRSwNP and CRSsNP
    Nora Barrett · 2022 · ImmPort