Mesenchymal inflammation drives genotoxic stress in hematopoietic stem cells and predicts disease evolution in human pre-leukemia

Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J. +15 more·2016·Cell stem cell
DOI 10.1016/j.stem.2016.08.021

Cited by (342)

Items 301–342 of 342

  1. Alterations of HSC Niche in Myeloid Malignancies
    L. Han, Marina Y Konopleva · 2017 · Advances in stem cells and their niches
  2. A vérképzőőssejt-niche szerepe a hematológiai neopláziák iniciációjában és progressziójában
    Zsolt Matula, Gábor Mikala, S. Veronika Urbán, Istvan T. Valyi-Nagy, Ferenc Uher · 2018 · Hematológia–Transzfuziológia
  3. Roman warfare: targeting of support cells in AML
    Catherine Choy Smith · 2019 · Blood
  4. Good news for acute myeloid leukaemia patients from the stroll niche?
    Marilena Ciciarello, Antonio Curti · 2020 · British Journal of Haematology
  5. Characterization by Next Generation Sequencing of mutations of spliceosome genes and bone marrow mesenchymal cells in patients with myelodysplastic syndromes
    Kamila Janusz · 2019
  6. MDS Stem Cell Biology
    Matthew T. Villaume, Paul Brent Ferrell, Michael Robert Savona · 2020 · Springer eBooks
  7. The Bone Marrow Microenvironment in Myelodysplastic Syndromes
    Laura Maria Calvi, Jane L. Liesveld · 2019 · The Hematologist
  8. Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human
    Jin Ye, Isabel A. Calvo, Itziar Cenzano, Amaia Vilas‐Zornoza, Xabier Martinez‐de‐Morentin, Miren Lasaga, Diego Alignani, Bruno Paiva, Ana C. Viñado, Patxi San Martín‐Úriz et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  9. Papel de la proteína quinasa C (PKC) en el crecimiento de células de leucemia linfoide aguda tipo B, en el soporte que les proporcionan las células stem mesenquimales y en su funcionalidad en un modelo in vitro de nicho leucémico
    Vanegas Avendaño, Natalia-Del Pilar · 2021
  10. Dissecting diversity: clonal analysis of normal and malignant hematopoiesis using cellular barcodes
    Sabrina Jacobs · 2021
  11. Deep Deconvolution of the Hematopoietic Stem Cell Regulatory Microenvironment Reveals a High Degree of Specialization and Conservation Between Mouse and Human
    Jin Ye, Isabel A. Calvo, Itziar Cenzano, Amaia Vilas‐Zornoza, Xavier Martinez Demorentin, Miren Lasaga, Diego Alignani, Bruno Pavia, Ana C. Viñado, Patxi San Martín‐Úriz et al. · 2021 · SSRN Electronic Journal
  12. Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
    Shiori Kinoshita, Satoshi Tanida, Akimi Kawai, Kazuhide Shiraga, Tomoyuki Nakamura, Kana Oiwa, Tomotaka Suzuki, Asahi Ito, Masaki Ri, Shigeru Kusumoto et al. · 2022 · Journal of Clinical Medicine Research
  13. Single-Cell Analysis of Nonhematopoietic Cells in Bone Marrow
    Puneet Agarwal, Victoria R. Matkins, Robert S. Welner · 2019 · Elsevier eBooks
  14. Faculty Opinions recommendation of A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia.
    Simón Méndez‐Ferrer · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  15. Faculty Opinions recommendation of How hscs colonize and expand in the fetal niche of the vertebrate embryo: an evolutionary perspective.
    Jason M. Butler · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  16. Taper up-off treatment of opium may reverse some dysregulations of gene expression patterns caused by four type of leukemia, AML, ALL, CML and CLL; a pilot animal model study
    Hossein Dezhakam, Ani Dezhakam, Arvin Haghighatfard · 2022 · Gastroenterology & Hepatology Open Access
  17. Deconvolution Of Hematopoietic Stem/Progenitor Cell Signaling Predicts Inflammatory Niche Remodeling To Be A Determinant Of Tissue Failure And Outcome In Human AML
    Lanpeng Chen, Eline Pronk, Claire van Dijk, Yujie Bian, Jacqueline Feyen, Tim V. D. van Tienhoven, Meltem Yildirim, Paola Pisterzi, Madelon M.E. de Jong, Alejandro Bastidas et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  18. [Mechanisms by which the bone marrow microenvironment of myelodysplastic neoplasms contributes to disease progression].
    Ming Hong, Chunkang Chang · 2023 · PubMed Central
  19. Basic Hematopoiesis and Leukemia Stem Cells
    William Ying Khee Hwang, Sudipto Bari, Lai Guan Ng, Koji Itahana, Shang Li, Javier Yu Peng Koh, Hein Than · 2023 · Springer eBooks
  20. The myelodysplastic syndromes
    Johanna S. Ungerstedt, Magnus Tobiasson, Eva Hellström‐Lindberg · 2025 · Wiley eBooks
  21. Tumor necrosis factor from leukemic environment stimulates hematopoietic stem / progenitor cells toward megakaryocyte / myeloid lineage bias.
    Hidekazu Nishikii, Riko Kikuchi, Takaharu Kimura, M. Saito, Y. Kiyoki, Saki Tanaka, Y. Sasaki, Takayasu Kato, Tatsuhiro Sakamoto, M. Sakata-Yanagimoto et al. · 2025 · Experimental Hematology
  22. Aberrant Kupffer-like differentiation of hematopoietic stem cell is critical for the MDS pathogenesis in Setd2-deficient mice
    Jiachun Song, Fang Wang, Yinyin Xie, Xinyue Luo, Hong Tao, Rong Fan, Yan Zhou, Jing Wu, Ting Huang, Haifeng Zhao et al. · 2026 · Cell Death and Differentiation
  23. Osteoimmunology
    Kazuo Okamoto, Hiroshi Takayanagi · 2026 · Elsevier eBooks
  24. The bone marrow microenvironment in myelodysplastic syndromes : functional and molecular study
    Marie Goulard · 2017 · theses.fr (ABES)
  25. Incidence de l'hypoxie sur le métabolisme oxydatif des leucémies aiguës myéloïdes : établissement et caractérisation d'un modèle in vitro de niche leucémique
    Margaux Deynoux · 2019
  26. Altered interactions between mesenchymal stromal cells and hematopoietic stem cells from MDS and AML through expression of FAK
    Yuenv Wu · 2019
  27. Impact des pesticides sur le microenvironnement médullaire des hémopathies myéloïdes
    Amélie Foucault · 2021 · theses.fr (ABES)
  28. Rôle des cellules stromales périostéales dans la régénération de la niche hématopoïétique
    Tony Marchand · 2021 · theses.fr (ABES)
  29. Complications hématologiques du syndrome de Shwachman-Diamond : neutropénie et leucémie aiguë myéloïde
    Jean‐Alain Martignoles · 2022
  30. Rôle des cellules myéloïdes suppressives (MDSCs) dans les syndromes myélodysplasiques / Leucémies aiguës myéloïdes dans le contexte de l'allogreffe de cellules souches hématopoïétiques
    Allan Bertrand · 2023
  31. Inflammation et hématopoïèse – Rôles de la Calprotectine et de la protéine IGFBP2 (Insulin like Growth Factor Binding Protein 2)
    Valentine Marchand · 2024 · theses.fr (ABES)
  32. Functional exploration of congenital neutropenia due to mutations in ribosome associated proteins SBDS and GRWD1
    Nawa Hachem · 2024
  33. Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy
    Adele Bottaro, Maria Elisa Nasso, Giuseppe Mirabile, Manlio Fazio, Alessandro Allegra · 2026 · Cells
  34. Ribosome biogenesis and selective translational control as oncogenic vulnerabilities in hematologic malignancies
    Juan Luiz Coelho‐Silva, João Agostinho Machado‐Neto · 2026 · Molecular Cancer
  35. PANoptosis in the pathogenesis of myelodysplastic syndromes
    Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang · 2026 · Molecular Oncology
  36. Culture enhanced MSCs to boost haematopoietic engraftment in a model of the post-leukaemic bone marrow niche
    Ioannis Angelos Tsigkos, Yusuf Ayten, Penelope M. Tsimbouri, Massimo Vassalli, Manuel Salmerón‐Sánchez, Matthew John Dalby · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Qinghuang powder ameliorates cellular senescence and energy metabolism abnormalities in bone marrow mesenchymal stem cells of myelodysplastic syndromes
    Peizhen Jiang, Daxiang Sun, Yaoyin Zhang, Dexiu Wang, Jiaqi He, Xudong Tang · 2026 · Journal of Ethnopharmacology
  38. From bone marrow failure to myeloid malignancies: Multi-dimensional mechanistic insights and therapeutic perspectives
    Jicheng Ding, Yimeng Jiang, Zhengrong Xu, Ying Zheng, Lili Pan · 2026 · Cell investigation.
  39. Tumor necrosis factor from leukemic environment stimulates hematopoietic stem/progenitor cells toward megakaryocyte/myeloid lineage bias
    Hidekazu Nishikii, Kikuchi Riko, Takaharu Kimura, Kikuchi Riko, Takaharu Kimura, Saito Mizuki, Yusuke Kiyoki, Tanaka Saki, Sasaki Yamato, Takayasu Kato et al. · 2026 · Institutional Repositories DataBase (IRDB)
  40. Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo
    Tiffany N. Razabdouski, Robert Dalton, Alexandra R. Calescibetta, Sean Christiansen, Grace Ward, Anthony C. Augello, Jungwon Moon, Seongseok Yun, Nicole D. Vincelette, Gabriela M. Wright et al. · 2026 · Cells
  41. Metabolic processes and microenvironmental regulation in leukemia
    Binhe Chang, Yong Wang, Zijuan Li, Muying Zhao, Chuhan Deng, Yiyi Ren, Qijing Li, Xiaojian Sun, Lan Wang · 2026 · Chinese Medical Journal
  42. Imaging and Analyzing the Macrophages that Regulate Pathological Hematopoietic Clones in the Mouse Calvarial Bone Marrow
    Jacky Chen, Kevin Lee, Ryan Adapathya, Cih-Li Hong, Shu-Chi Allison Yeh · 2026 · Methods in molecular biology