Mesenchymal inflammation drives genotoxic stress in hematopoietic stem cells and predicts disease evolution in human pre-leukemia
Open accessAbstract
Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and relevance to human disease remain poorly defined. Here, we show that perturbation of mesenchymal cells in a mouse model of the pre-leukemic disorder Shwachman-Diamond syndrome (SDS) induces mitochondrial dysfunction, oxidative stress, and activation of DNA damage responses in hematopoietic stem and progenitor cells. Massive parallel RNA sequencing of highly purified mesenchymal cells in the SDS mouse model and a range of human pre-leukemic syndromes identified p53-S100A8/9-TLR inflammatory signaling as a common driving mechanism of genotoxic stress. Transcriptional activation of this signaling axis in the mesenchymal niche predicted leukemic evolution and progression-free survival in myelodysplastic syndrome (MDS), the principal leukemia predisposition syndrome. Collectively, our findings identify mesenchymal niche-induced genotoxic stress in heterotypic stem and progenitor cells through inflammatory signaling as a targetable determinant of disease outcome in human pre-leukemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A defective bone marrow environment can give rise to hematological malignancies.
“hematological malignancies can result from a defective bone marrow environment.”
From Aging of hematopoietic stem cells (2018) · cites this paper as [44]
Raaijmakers and colleagues confirmed these results and additionally showed increased levels of S100A8 in the mesenchymal niche in MDS and Shwachman-Bodian-Diamond syndrome, which affects HSCs through excessive ROS production and genotoxic stress.
“Raaijmakers and colleagues confirmed these results and additionally showed increased levels of S100A8 in the mesenchymal niche in MDS and Shwachman-Bodian-Diamond syndrome, which affects HSCs through excessive reactive oxygen species (ROS) production and genotoxic stress.68,71”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works
g:Profiler—a web-based toolset for functional profiling of gene lists from large-scale experiments
Reimand, J., Kull, M., Peterson, H., Hansen, J., & Vilo, J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm226 · Cited by 1,525 · see citing works
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · see citing works
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115 · see citing works
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Raaijmakers, M. H. G. P., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010) · Nature · doi:10.1038/nature08851 · Cited by 1,115 · see citing works
Jonkers, J., Meuwissen, R. L. J., van der Gulden, H. M. L., Peterse, H. L., van der Valk, M., & Berns, A. J. M. (2001) · Nature Genetics · doi:10.1038/ng747 · Cited by 1,053 · see citing works
DNA repair dysregulation from cancer driver to therapeutic target
Curtin, N. J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3399 · Cited by 1,051 · see citing works
Marino, S., Vooijs, M., van der Gulden, H., Jonkers, J., & Berns, A. (2000) · Genes & Development · doi:10.1101/gad.14.8.994 · Cited by 920 · see citing works
Cheng, P., Corzo, C. A., Luetteke, N., Yu, B., Nagaraj, S., Bui, M. M., Ortiz, M. L., Nacken, W. K. F., Sorg, C., Vogl, T., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080132 · Cited by 904 · see citing works
Mutations in SBDS are associated with Shwachman–Diamond syndrome
Boocock, G. R. B., Morrison, J. A., Popovic, M., Richards, N., Ellis, L. E., Durie, P. R., & Rommens, J. M. (2002) · Nature Genetics · doi:10.1038/ng1062 · Cited by 785 · see citing works
Linking functional decline of telomeres, mitochondria and stem cells during ageing
Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759 · see citing works
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Starczynowski, D. T., Kuchenbauer, F. C., Argiropoulos, B., Sung, S., Morin, R. D., Muranyi, A., Hirst, M., Hogge, D. E., Marra, M. A., Wells, R. A., et al. (2009) · Nature Medicine · doi:10.1038/nm.2054 · Cited by 655 · see citing works
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Walter, D., Lier, A., Geiselhart, A., Thalheimer, F. B., Huntscha, S., Sobotta, M. C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., et al. (2015) · Nature · doi:10.1038/nature14131 · Cited by 619 · see citing works
Schepers, K., Pietras, E. M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A. J., Hsiao, E. C., & Passegué, E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.009 · Cited by 614 · see citing works
A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency
Walkley, C. R., Olsen, G. H., Dworkin, S., Fabb, S. A., Swann, J. B., McArthur, G. A., Westmoreland, S. V., Chambon, P., Scadden, D. T., & Purton, L. E. (2007) · Cell · doi:10.1016/j.cell.2007.05.014 · Cited by 535 · see citing works
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
Kode, A., Manavalan, J. S., Mosialou, I., Bhagat, G., Rathinam, C. V., Luo, N., Khiabanian, H., Lee, A., Murty, V. V. V. S., Friedman, R. A., et al. (2014) · Nature · doi:10.1038/nature12883 · Cited by 530 · see citing works
g:Profiler—a web server for functional interpretation of gene lists (2011 update)
Reimand, J., Arak, T., & Vilo, J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr378 · Cited by 504 · see citing works
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
Tormin, A., Li, O., Brune, J. C., Walsh, S., Schütz, B., Ehinger, M., Ditzel, N., Kassem, M., & Scheding, S. (2011) · Blood · doi:10.1182/blood-2010-08-304287 · Cited by 460 · see citing works
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Arranz, L., Sánchez-Aguilera, A., Martín-Pérez, D., Isern, J., Langa, X., Tzankov, A., Lundberg, P., Muntión, S., Tzeng, Y.-S., Lai, D.-M., et al. (2014) · Nature · doi:10.1038/nature13383 · Cited by 444 · see citing works
Bejar, R. L., Stevenson, K. E., Caughey, B. A., Abdel-Wahab, O. I., Steensma, D. P., Galili, N., Raza, A., Kantarjian, H. M., Levine, R. L., Neuberg, D. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.7379 · Cited by 442 · see citing works
Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
Schepers, K., Campbell, T., & Passegué, E. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.014 · Cited by 416 · see citing works
Medyouf, H., Mossner, M., Jann, J.-C., Nolte, F., Raffel, S., Herrmann, C., Lier, A., Eisen, C., Nowak, V., Zens, B., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.014 · Cited by 388 · see citing works
Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U., & Frenette, P. S. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.020 · Cited by 381 · see citing works
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
Owusu-Ansah, E., Yavari, A., Mandal, S., & Banerjee, U. K. (2008) · Nature Genetics · doi:10.1038/ng.2007.50 · Cited by 364 · see citing works
Induction of myelodysplasia by myeloid-derived suppressor cells
Chen, X., Eksioglu, E. A., Zhou, J., Zhang, L., Djeu, J., Fortenbery, N., Epling-Burnette, P., Van Bijnen, S., Dolstra, H., Cannon, J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67580 · Cited by 316 · see citing works
Vlachos, A., Rosenberg, P. S., Atsidaftos, E., Alter, B. P., & Lipton, J. M. (2012) · Blood · doi:10.1182/blood-2011-08-375972 · Cited by 309 · see citing works
Yahata, T., Takanashi, T., Muguruma, Y., Ibrahim, A. A., Matsuzawa, H., Uno, T., Sheng, Y., Onizuka, M., Ito, M., Kato, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-330050 · Cited by 298 · see citing works
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndromePreprint
Finch, A. J., Hilcenko, C., Basse, N., Drynan, L. F., Goyenechea, B., Menne, T., González‐Fernández, Á., Simpson, P. J., D’Santos, C. S., Arends, M. J., et al. (2011) · Genes & Development · doi:10.1101/gad.623011 · Cited by 292 · see citing works
Srikrishna, G., & Freeze, H. H. (2009) · Neoplasia · doi:10.1593/neo.09284 · Cited by 274 · see citing works
Shwachman's syndrome. A review of 21 cases.
Aggett, P. J., Cavanagh, N. P., Matthew, D. J., Pincott, J. R., Sutcliffe, J., & Harries, J. T. (1980) · Archives of Disease in Childhood · doi:10.1136/adc.55.5.331 · Cited by 264 · see citing works
Wang, X., Kua, H.-Y., Hu, Y., Guo, K., Zeng, Q., Wu, Q., Ng, H., Karsenty, G., Crombrugghe, B. D., Yeh, J. K., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507106 · Cited by 250 · see citing works
Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes
Gañán-Gómez, I., Wei, Y., Starczynowski, D. T., Colla, S., Yang, H., Cabrero-Calvo, M., Bohannan, Z. S., Verma, A., Steidl, U., & Garcia-Manero, G. (2015) · Leukemia · doi:10.1038/leu.2015.69 · Cited by 236 · see citing works
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
Schneider, R. K., Schenone, M., Ferreira, M. S. V., Kramann, R., Joyce, C. E., Hartigan, C. R., Beier, F., Brümmendorf, T. H., Germing, U., Platzbecker, U., et al. (2016) · Nature Medicine · doi:10.1038/nm.4047 · Cited by 236 · see citing works
Ginzberg, H. H., Shin, J., Ellis, L. E., Morrison, J. A., Ip, W., Dror, Y., Freedman, M. H., Heitlinger, L. A., Belt, M. A., Corey, M. L., et al. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70332-x · Cited by 234 · see citing works
Diagnosis, Genetics, and Management of Inherited Bone Marrow Failure Syndromes
Alter, B. P. (2007) · Hematology · doi:10.1182/asheducation-2007.1.29 · Cited by 230 · see citing works
Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity
Vogl, T., Eisenblätter, M., Völler, T., Zenker, S., Hermann, S., van Lent, P., Faust, A., Geyer, C., Petersen, B., Roebrock, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5593 · Cited by 193 · see citing works
Toll-like receptor alterations in myelodysplastic syndrome
Wei, Y., Dimicoli, S., Bueso‐Ramos, C. E., Chen, R., Yang, H., Neuberg, D. S., Pierce, S. A., Jia, Y., Zheng, H., Wang, H., et al. (2013) · Leukemia · doi:10.1038/leu.2013.180 · Cited by 159 · see citing works
Donadieu, J., Fenneteau, O., Beaupain, B., Beaufils, S., Bellanger, F., Mahlaoui, N., Lambilliotte, A., Aladjidi, N., Bertrand, Y., Mialou, V., et al. (2012) · Haematologica · doi:10.3324/haematol.2011.057489 · Cited by 158 · see citing works
Maratheftis, C. I., Andreakos, E., Moutsopoulos, H. Μ., & Voulgarelis, M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2108 · Cited by 139 · see citing works
Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome
Austin, K. M., Gupta, M. L., Coats, S. A., Tulpule, A., Mostoslavsky, G., Balazs, A. B., Mulligan, R. C., Daley, G. Q., Pellman, D. S., & Shimamura, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33764 · Cited by 137 · see citing works
Skeletal phenotype in patients with Shwachman–Diamond syndrome and mutations in SBDS
Mäkitie, O., Ellis, L. E., Durie, P. R., Morrison, J., Sochett, E., Rommens, J., & Cole, W. (2004) · Clinical Genetics · doi:10.1111/j.0009-9163.2004.00198.x · Cited by 135 · see citing works
Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome
Woloszynek, J. R., Rothbaum, R., Rawls, A. S., Minx, P. J., Wilson, R. K., Mason, P. J., Bessler, M., & Link, D. C. (2004) · Blood · doi:10.1182/blood-2004-04-1516 · Cited by 127 · see citing works
Peddie, C. M., Wolf, C. R., McLellan, L. I., Collins, A. R., & Bowen, D. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.4373247.x · Cited by 106 · see citing works
Li, L., Li, M., Sun, C., Francisco, L., Chakraborty, S., Sabado-Liwag, M., McDonald, T., Gyorffy, J. B., Chang, K. L., Wang, S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.011 · Cited by 86 · see citing works
Figueroa, E. F., Varma, S., Montgomery, K. D., Greenberg, P. L., & Gratzinger, D. A. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.93 · Cited by 85 · see citing works
Chen, S., Zambetti, N. A., Bindels, E. M. J., Kenswill, K., Mylona, A. M., Adisty, N. M., Hoogenboezem, R. M., Sanders, M. A., Cremers, E. M. P., Westers, T. M., et al. (2016) · Leukemia · doi:10.1038/leu.2016.91 · Cited by 79 · see citing works
Ball, H. L., Zhang, B., Riches, J. J., Gandhi, R. A., Li, J., Rommens, J. M., & Myers, J. S. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp316 · Cited by 77 · see citing works
Li, C., Chen, H., Ding, F., Zhang, Y., Luo, A., Wang, M., & Liu, Z. (2009) · Biochemical Journal · doi:10.1042/bj20090465 · Cited by 70 · see citing works
The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders
Raiser, D. M., Narla, A., & Ebert, B. L. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.812786 · Cited by 64 · see citing works
Zambetti, N. A., Bindels, E. M., van Strien, P. M. H., Valkhof, M. G., Adisty, M. N., Hoogenboezem, R. M., Sanders, M. A., Rommens, J. M., Touw, I. P., & Raaijmakers, M. H. G. P. (2015) · Haematologica · doi:10.3324/haematol.2015.131573 · Cited by 60 · see citing works
Rawls, A. S., Gregory, A. D., Woloszynek, J. R., Liu, F., & Link, D. C. (2007) · Blood · doi:10.1182/blood-2006-03-007112 · Cited by 57 · see citing works
Shwachman–Diamond syndrome is associated with low-turnover osteoporosis
Toiviainen‐Salo, S., Mäyränpää, M. K., Durie, P. R., Richards, N., Grynpas, M. D., Ellis, L. E., Ikegawa, S., Cole, W. G., Rommens, J. M., Marttinen, E. J., et al. (2007) · Bone · doi:10.1016/j.bone.2007.08.035 · Cited by 57 · see citing works
Ambekar, C., Das, B., Yeger, H., & Dror, Y. (2010) · Pediatric Blood & Cancer · doi:10.1002/pbc.22700 · Cited by 56 · see citing works
Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio
Tudpor, K., van der Eerden, B. C. J., Jongwattanapisan, P., Roelofs, J. J. T. H., van Leeuwen, J. P. T. M., Bindels, R. J. M., & Hoenderop, J. G. J. (2014) · Bone · doi:10.1016/j.bone.2014.11.004 · Cited by 26 · see citing works
Xiao, Y., Wang, J., Song, H. K., Zou, P., Zhou, D., & Liu, L. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.11.006 · Cited by 15 · see citing works
Head, D. R., Jacobberger, J. W., Mosse, C. A., Jagasia, M., Dupont, W. D., Goodman, S. A., Flye, L. A., Shinar, A. A., McClintock-Treep, S. A., Stelzer, G. T., et al. (2011) · Bone Marrow Research · doi:10.1155/2011/950934 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P.V., Mar, B.G., Lindsley, R.C., Mermel, C.H., Burtt, N., Chavez, A., et al. (2014). Agerelated clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371 , 2488-2498. http://refhub.elsevier.com/S1934-5909(1630268-5/sref22)
Cited by
Sorted by citations
Haematopoietic stem cell activity and interactions with the niche
Pinho, S., & Frenette, P. S. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0103-9 · Cited by 990 · see citing works
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Baryawno, N., Przybylski, D., Kowalczyk, M. S., Kfoury, Y. S., Sévère, N., Gustafsson, K. U., Kokkaliaris, K. D., Mercier, F., Tabaka, M., Hofree, M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.040 · Cited by 882 · see citing works
Adult haematopoietic stem cell niches
Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712 · see citing works
Bone marrow niches in haematological malignancies
Méndez‐Ferrer, S., Bonnet, D. A., Steensma, D. P., Hasserjian, R. P., Ghobrial, I. M., Gribben, J. G., Andreeff, M., & Krause, D. S. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0245-2 · Cited by 486 · see citing works
Aging of hematopoietic stem cells
de Haan, G., & Lazare, S. S. (2018) · Blood · doi:10.1182/blood-2017-06-746412 · Cited by 432 · see citing works
Therapy-related myeloid neoplasms: when genetics and environment collide
McNerney, M. E., Godley, L. A., & Beau, M. M. L. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.60 · Cited by 422 · see citing works
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Kang, J., Brajanovski, N., Chan, K. T., Xuan, J., Pearson, R. B., & Sanij, E. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00728-8 · Cited by 412 · see citing works
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
Pietras, E. M. (2017) · Blood · doi:10.1182/blood-2017-06-780882 · Cited by 417 · see citing works
Vitale, I., Manic, G., De Maria, R., Kroemer, G., & Galluzzi, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.006 · Cited by 361 · see citing works
Tet2 restrains inflammatory gene expression in macrophages
Cull, A. H., Snetsinger, B., Buckstein, R., Wells, R. A., & Rauh, M. J. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.08.001 · Cited by 295 · see citing works
Inflammation-Induced Tumorigenesis and Metastasis
Hibino, S., Kawazoe, T., Kasahara, H., Itoh, S., Ishimoto, T., Sakata‐Yanagimoto, M., & Taniguchi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115421 · Cited by 303 · see citing works
The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
Sallman, D. A., & List, A. (2019) · Blood · doi:10.1182/blood-2018-10-844654 · Cited by 273 · see citing works
Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths
Wolock, S. L., Krishnan, I., Tenen, D. E., Matkins, V. R., Camacho, V., Patel, S. B., Agarwal, P., Bhatia, R., Tenen, D. G., Klein, A. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.031 · Cited by 229 · see citing works
Chronic immune response dysregulation in MDS pathogenesis
Barreyro, L., Chlon, T. M., & Starczynowski, D. T. (2018) · Blood · doi:10.1182/blood-2018-03-784116 · Cited by 226 · see citing works
Kampen, K. R., Sulima, S. O., Vereecke, S., & Keersmaecker, K. D. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz637 · Cited by 217 · see citing works
MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts
Wallace, J. A., & O’Connell, R. M. (2017) · Blood · doi:10.1182/blood-2016-10-697698 · Cited by 203 · see citing works
Ribosomopathies: Old Concepts, New Controversies
Farley‐Barnes, K. I., Ogawa, L. M., & Baserga, S. J. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.07.004 · Cited by 183 · see citing works
Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis
Yamashita, M., Dellorusso, P. V., Olson, O. C., & Passegue, E. A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0260-3 · Cited by 182 · see citing works
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
Leimkühler, N. B., Gleitz, H. F. E., Li, R., Snoeren, I., Fuchs, S. N. R., Nagai, J. S., Banjanin, B., Lam, K. H., Vogl, T., Kuppe, C., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.11.004 · Cited by 178 · see citing works
Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome
Warren, A. J. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.09.002 · Cited by 177 · see citing works
Myeloid malignancies and the microenvironment
Korn, C., & Méndez‐Ferrer, S. (2016) · Blood · doi:10.1182/blood-2016-09-670224 · Cited by 169 · see citing works
The bone-marrow niche in MDS and MGUS: implications for AML and MM
Ghobrial, I. M., Detappe, A., Anderson, K. C., & Steensma, D. P. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.197 · Cited by 151 · see citing works
Mesenchymal stem cells: From regeneration to cancer
Li, P., Gong, Z., Shultz, L. D., & Ren, G. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.005 · Cited by 134 · see citing works
The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications
Medyouf, H. (2017) · Blood · doi:10.1182/blood-2016-11-696070 · Cited by 127 · see citing works
Abarrategi, A., Mian, S. A., Passaro, D., Rouault‐Pierre, K., Grey, W., & Bonnet, D. A. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172139 · Cited by 126 · see citing works
Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation
Verovskaya, E. V., Dellorusso, P. V., & Passegue, E. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.006 · Cited by 122 · see citing works
The influence of microenvironment on tumor immunotherapy
Zhang, J., Shi, Z., Xu, X., Yu, Z., & Mi, J. (2019) · FEBS Journal · doi:10.1111/febs.15028 · Cited by 112 · see citing works
How I treat chronic myelomonocytic leukemia
Solary, É., & Itzykson, R. (2017) · Blood · doi:10.1182/blood-2017-04-736421 · Cited by 112 · see citing works
Myelodysplastic syndromes: moving towards personalized management
Hellström‐Lindberg, E., Tobiasson, M., & Greenberg, P. L. (2020) · Haematologica · doi:10.3324/haematol.2020.248955 · Cited by 106 · see citing works
Regulation of the Bone Marrow Niche by Inflammation
Mitroulis, I., Kalafati, L., Bornhäuser, M., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01540 · Cited by 112 · see citing works
Acute Myeloid Leukemia: The Good, the Bad, and the Ugly
Kuykendall, A. T., Duployez, N., Boissel, N., Lancet, J. E., & Welch, J. S. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_199519 · Cited by 111 · see citing works
Edwards, D. K., V, Watanabe‐Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A. J., Lind, E. F., Kaempf, A. J., Mori, M., Rosenberg, M. W., et al. (2018) · Blood · doi:10.1182/blood-2018-03-838946 · Cited by 107 · see citing works
Cheng, P., Eksioglu, E. A., Chen, X., Kandell, W. M., Trinh, T. L., Cen, L., Qi, J., Sallman, D. A., Zhang, Y., Tu, N., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0397-9 · Cited by 103 · see citing works
Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells
Hemmati, S., Haque, T. Z., & Gritsman, K. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00265 · Cited by 101 · see citing works
Diagnosis, Treatment, and Molecular Pathology of Shwachman-Diamond Syndrome
Nelson, A. S., & Myers, K. C. (2018) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2018.04.006 · Cited by 100 · see citing works
The Hematopoietic Bone Marrow Niche Ecosystem
Fröbel, J., Landspersky, T., Perçin, G. I., Schreck, C., Rahmig, S., Ori, A., Nowak, D., Essers, M. A. G., Waskow, C., & Oostendorp, R. A. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705410 · Cited by 97 · see citing works
IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
Bennett, J., & Starczynowski, D. T. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000693 · Cited by 100 · see citing works
Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells
Kandarakov, O. F., Belyavsky, A. V., & Semenova, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084462 · Cited by 97 · see citing works
Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia
Menendez-Gonzalez, J. B., Vukovic, M., Abdelfattah, A., Saleh, L., Almotiri, A., Thomas, L.-A., Lizaso, A. A., Azevedo, A., Menezes, A. C., Tornillo, G., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.07.005 · Cited by 97 · see citing works
Rodrigues-Moreira, S., Moreno, S. G., Ghinatti, G., Lewandowski, D., Hoffschir, F., Ferri, F., Gallouët, A.-S., Gay, D. L., Motohashi, H., Yamamoto, M. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.013 · Cited by 94 · see citing works
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91 · see citing works
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82 · see citing works
Cancer Biogenesis in Ribosomopathies
Sulima, S. O., Kampen, K. R., & Keersmaecker, K. D. (2019) · Cells · doi:10.3390/cells8030229 · Cited by 85 · see citing works
Reilly, C. R., & Shimamura, A. (2022) · Blood · doi:10.1182/blood.2022017739 · Cited by 85 · see citing works
Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment
Medinger, M., Drexler, B., Lengerke, C., & Passweg, J. R. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00587 · Cited by 84 · see citing works
Winter, S., Shoaie, S., Kordasti, S. Y., & Platzbecker, U. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.01823 · Cited by 82 · see citing works
Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities
Marchand, T., & Pinho, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775128 · Cited by 82 · see citing works
Turning the tide in myelodysplastic/myeloproliferative neoplasms
Deininger, M. W., Tyner, J. W., & Solary, É. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.40 · Cited by 80 · see citing works
Dander, E., Palmi, C., D’Amico, G., & Cazzaniga, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094426 · Cited by 80 · see citing works
Somatic genetic rescue of a germline ribosome assembly defect
Tan, S., Kermasson, L., Hilcenko, C., Kargas, V. E., Traynor, D., Boukerrou, A. Z., Escudero-Urquijo, N., Faille, A., Bertrand, A., Rossmann, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24999-5 · Cited by 79 · see citing works
Targeting the interleukin-1 pathway in patients with hematological disorders
de Mooij, C. E. M., Netea, M. G., van der Velden, W. J. F. M., & Blijlevens, N. M. A. (2017) · Blood · doi:10.1182/blood-2016-12-754994 · Cited by 79 · see citing works
IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia
Zhang, T. Y., Dutta, R., Benard, B. A., Zhao, F., Yin, R. R., & Majeti, R. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax5104 · Cited by 77 · see citing works
Wang, T., Pine, A. R., Kotini, A. G., Yuan, H., Zamparo, L., Starczynowski, D. T., Leslie, C. S., & Papapetrou, E. P. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.011 · Cited by 77 · see citing works
Poon, Z., Dighe, N., Venkatesan, S. S., Cheung, A. M. S., Fan, X., Bari, S., Hota, M., Ghosh, S., & Hwang, W. Y. K. (2018) · Leukemia · doi:10.1038/s41375-018-0310-y · Cited by 74 · see citing works
Ferrone, C. K., Blydt-Hansen, M., & Rauh, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020626 · Cited by 75 · see citing works
Pronk, E., & Raaijmakers, M. H. G. P. (2019) · Blood · doi:10.1182/blood-2018-10-844639 · Cited by 72 · see citing works
Wang, B., Reville, P. K., Yassouf, M. Y., Jelloul, F. Z., Ly, C. P., Desai, P. N., Wang, Z., Borges, P., Veletić, I., Dasdemir, E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45916-6 · Cited by 74 · see citing works
Impact of Mesenchymal Stem Cell Senescence on Inflammaging
Lee, B.-C., & Yu, K. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.2.291 · Cited by 70 · see citing works
Cell interactions in the bone marrow microenvironment affecting myeloid malignancies
Kokkaliaris, K. D., & Scadden, D. T. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002127 · Cited by 67 · see citing works
Chavakis, T., Wielockx, B., & Hajishengallis, G. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-052521-013627 · Cited by 70 · see citing works
The impact of ribosome biogenesis in cancer: from proliferation to metastasis
Hwang, S.-P., & Denicourt, C. (2024) · NAR Cancer · doi:10.1093/narcan/zcae017 · Cited by 69 · see citing works
Belderbos, M. E., Koster, T., Dethmers-Ausema, B., Jacobs, S., Sowdagar, S., Zwart, E., de Bont, E. S., de Haan, G., & Bystrykh, L. V. (2017) · Blood · doi:10.1182/blood-2016-12-758250 · Cited by 68 · see citing works
VEGF-C protects the integrity of the bone marrow perivascular niche in mice
Fang, S., Chen, S., Nurmi, H. J., Leppänen, V., Jeltsch, M., Scadden, D. T., Silberstein, L., Mikkola, H. K. A., & Alitalo, K. K. (2020) · Blood · doi:10.1182/blood.2020005699 · Cited by 65 · see citing works
Progress in low dose health risk research
Averbeck, D., Salomaa, S. I., Bouffler, S. D., Ottolenghi, A., Smyth, V., & Sabatier, L. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.04.001 · Cited by 67 · see citing works
The microenvironment in myelodysplastic syndromes: Niche-mediated disease initiation and progression
Li, A. J., & Calvi, L. M. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.08.003 · Cited by 63 · see citing works
Mondet, J., Chevalier, S., & Mossuz, P. (2021) · Molecules · doi:10.3390/molecules26051323 · Cited by 61 · see citing works
The Bone Marrow Microenvironment in Health and Myeloid MalignancyPreprint
Galán-Díez, M., Cuesta‐Domínguez, Á., & Kousteni, S. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031328 · Cited by 60 · see citing works
Nucleolar stress: Molecular mechanisms and related human diseases
Maehama, T., Nishio, M., Otani, J., Mak, T. W., & Suzuki, A. (2023) · Cancer Science · doi:10.1111/cas.15755 · Cited by 58 · see citing works
Overcoming Resistance to FLT3 Inhibitors in the Treatment of FLT3-Mutated AML
Lam, S. S. Y., & Leung, A. Y. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041537 · Cited by 57 · see citing works
Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation
Kenswil, K. J. G., Pisterzi, P., Sánchez‐Duffhues, G., van Dijk, C., Lolli, A., Knuth, C., Vanchin, B., Jaramillo, A. C., Hoogenboezem, R. M., Sanders, M. A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.006 · Cited by 57 · see citing works
Giallongo, C., Tibullo, D., Camiolo, G., Parrinello, N. L., Romano, A., Puglisi, F., Barbato, A., Conticello, C., Lupo, G., Anfuso, C. D., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1959-5 · Cited by 55 · see citing works
Kenswil, K. J. G., Jaramillo, A. C., Ping, Z., Chen, S., Hoogenboezem, R. M., Mylona, M., Adisty, M. N., Bindels, E. M. J., Bos, P. K., Stoop, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.070 · Cited by 54 · see citing works
Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes
Mattiucci, D., Maurizi, G., Leoni, P., & Poloni, A. (2018) · Cell Transplantation · doi:10.1177/0963689717745890 · Cited by 54 · see citing works
Habbel, J., Arnold, L., Chen, Y.-Y., Möllmann, M., Bruderek, K., Brandau, S., Dührsen, U., & Hanoun, M. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001292 · Cited by 54 · see citing works
Bone marrow inflammation in haematological malignancies
de Jong, M. M. E., Chen, L., Raaijmakers, M. H. G. P., & Cupedo, T. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01003-x · Cited by 54 · see citing works
Desbourdes, L. M., Javary, J., Charbonnier, T., Ishac, N., Bourgeais, J., Iltis, A., Chomel, J., Turhan, A. G., Guilloton, F., Tarte, K., et al. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0295 · Cited by 53 · see citing works
Dunbar, A. J., Kim, D., Lü, M., Farina, M., Bowman, R. L., Yang, J. L., Park, Y. C., Karzai, A., Xiao, W., Zaroogian, Z., et al. (2023) · Blood · doi:10.1182/blood.2022015418 · Cited by 53 · see citing works
ERCC6L2 defines a novel entity within inherited acute myeloid leukemia
Douglas, S. P. M., Siipola, P., Kovanen, P. E., Pyörälä, M., Kakko, S., Savolainen, E., Salmenniemi, U., Orte, K. J., Kytölä, S. I., Pitkänen, E., et al. (2019) · Blood · doi:10.1182/blood-2019-01-896233 · Cited by 55 · see citing works
Flaming and fanning: The Spectrum of inflammatory influences in myelodysplastic syndromes
Banerjee, T., Calvi, L. M., Becker, M. W., & Liesveld, J. L. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.04.004 · Cited by 51 · see citing works
Paracatu, L. C., & Schuettpelz, L. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01236 · Cited by 50 · see citing works
Ribezzo, F., Snoeren, I. A. M., Ziegler, S., Stoelben, J., Olofsen, P. A., Henic, A., Ferreira, M. V., Chen, S., Stalmann, U. S. A., Buesche, G., et al. (2019) · Leukemia · doi:10.1038/s41375-018-0350-3 · Cited by 51 · see citing works
The Osteoblastic Niche in Hematopoiesis and Hematological Myeloid Malignancies
Galán-Díez, M., & Kousteni, S. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0055-9 · Cited by 49 · see citing works
Ward, G., Dalton, R., Meyer, B. S., McLemore, A. F., Aldrich, A. L., Lam, N. B., Onimus, A., Vincelette, N. D., Trinh, T. L., Chen, X., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043896 · Cited by 50 · see citing works
Impact of inflammation on early hematopoiesis and the microenvironment
Takizawa, H., & Manz, M. G. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2266-5 · Cited by 48 · see citing works
Inflammation Regulates Haematopoietic Stem Cells and Their Niche
Ho, N. P. Y., & Takizawa, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031125 · Cited by 48 · see citing works
Zhuo, Y., Chen, W., Li, W., Huang, Y., Duan, D., Ge, L., He, J., Liu, J., Hu, Z., & Lü, M. (2021) · Aging · doi:10.18632/aging.202807 · Cited by 47 · see citing works
Inflammation and myeloid malignancy: quenching the flame
Stubbins, R. J., Platzbecker, U., & Karsan, A. (2022) · Blood · doi:10.1182/blood.2021015162 · Cited by 46 · see citing works
Bone Marrow Immune Microenvironment in Myelodysplastic Syndromes
Kouroukli, O., Symeonidis, A. S., Foukas, P. G., Maragkou, M., & Kourea, E. P. (2022) · Cancers · doi:10.3390/cancers14225656 · Cited by 48 · see citing works
Shwachman-Diamond syndromes: clinical, genetic, and biochemical insights from the rare variants
Kawashima, N., Oyarbide, U., Cipolli, M., Bezzerri, V., & Corey, S. J. (2023) · Haematologica · doi:10.3324/haematol.2023.282949 · Cited by 46 · see citing works
Role of the microenvironment in myeloid malignancies
Goulard, M. C., Dosquet, C., & Bonnet, D. A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2725-4 · Cited by 46 · see citing works
Ping, Z., Chen, S., Hermans, S. J. F., Kenswil, K. J. G., Feyen, J., van Dijk, C., Bindels, E. M., Mylona, A., Adisty, N., Hoogenboezem, R. M., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0267-x · Cited by 45 · see citing works
Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia
Barreyro, L., Sampson, A. M., Ishikawa, C., Hueneman, K. M., Choi, K., Pujato, M. A., Chutipongtanate, S., Wyder, M. A., Haffey, W. D., O'Brien, E. J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abb7695 · Cited by 45 · see citing works
Tracking the Evolution of Therapy-Related Myeloid Neoplasms Using Chemotherapy Signatures
Diamond, B. T., Ziccheddu, B., Maclachlan, K. H., Taylor, J., Boyle, E. M., Ossa, J. A., Jahn, J., Affer, M., Totiger, T. M., Coffey, D. G., et al. (2023) · Blood · doi:10.1182/blood.2022018244 · Cited by 44 · see citing works
Ciciarello, M., Corradi, G., Loscocco, F., Visani, G., Monaco, F., Cavo, M., Curti, A., & Isidori, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01135 · Cited by 44 · see citing works
Mapping and targeting of the leukemic microenvironment
Witkowski, M. T., Kousteni, S., & Aifantis, I. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190589 · Cited by 45 · see citing works
Gleitz, H. F. E., Benabid, A., & Schneider, R. K. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000669 · Cited by 41 · see citing works
Woods, K., & Guezguez, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714716 · Cited by 41 · see citing works
Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment
Camacho, V., McClearn, V., Patel, S. B., & Welner, R. S. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2184-6 · Cited by 40 · see citing works
Komrokji, R. S., Wei, S., Mailloux, A. W., Zhang, L., Padron, E., Sallman, D. A., Lancet, J. E., Tinsley, S., Nardelli, L. A., Pinilla-Ibarz, J. A., et al. (2018) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2018.12.005 · Cited by 40 · see citing works
Stetka, J., Vyhlidalova, P., Lanikova, L., Kořalková, P., Gurský, J., Hlusi, A., Flódr, P., Hubáčková, S., Bártek, J., Hodný, Z., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0813-7 · Cited by 40 · see citing works
- Authors
- Zambetti, N. A., Ping, Z., Chen, S., Kenswil, K. J. G., Mylona, M. A., Sanders, M. A., Hoogenboezem, R. M., Bindels, E. M. J., Adisty, M. N., Van Strien, P. M. H., van der Leije, C. S., Westers, T. M., Cremers, E. M. P., Milanese, C., Mastroberardino, P. G., van Leeuwen, J. P. T. M., van der Eerden, B. C. J., Touw, I. P., Kuijpers, T. W., Kanaar, R., van de Loosdrecht, A. A., Vogl, T., & Raaijmakers, M. H. G. P.
- Affiliations
- Erasmus MC Cancer Institute (NL)
- Cancer Center Amsterdam (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Erasmus MC (NL)
- University of Münster (DE)
- Corresponding author
- Raaijmakers, Marc H.G.P.
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 19
- Issue
- 5
- Pages
- 613-627
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2521273475
- Cited by
- 342
- References
- 65
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 27 · 2023: 35 · 2022: 35 · 2021: 44 · 2020: 45 · 2019: 46 · 2018: 32 · 2017: 36 · 2016: 3
- FWCI
- 31.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Create (Canterbury Christ Church University) (acceptedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- mesenchymal niche, hematopoietic stem cells, preleukemia, Shwachman-Diamond syndrome, myelodysplastic syndrome, genotoxic stress, DNA damage response, mitochondrial dysfunction, oxidative stress, p53, S100A8/S100A9, Toll-like receptor signaling, inflammation, disease progression, hematopoietic stem and progenitor cells
- MeSH terms
- Pathogen-Associated Molecular Pattern Molecules, Sp7 Transcription Factor, Shwachman-Diamond Syndrome, Animals, Bone and Bones, Bone Marrow Diseases, DNA Damage, DNA Repair, Hematopoietic Stem Cells, Humans, Inflammation, Leukemia, Lipomatosis, Mitochondria, S100 Proteins, Exocrine Pancreatic Insufficiency, Precancerous Conditions, Proteins, Risk Factors, Transcription Factors, Signal Transduction, Tumor Suppressor Protein p53, Treatment Outcome, Gene Deletion, Oxidative Stress, Disease Progression, Integrases, Toll-Like Receptors, Mice, Stem Cell Niche, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
