Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain
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The authors' group and others have shown evidence of neurogenesis throughout adulthood using double immunofluorescence, in situ hybridization, and 14C decay-defined neuronal age.
“However, our group and others have shown evidence of neurogenesis throughout adulthood using double immunofluorescence98-101, in situ hybridization102 and 14C decay-defined neuronal age103.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [101]
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Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422 · see citing works
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345 · see citing works
Self-citationEncinas, J. M., Michurina, T. V., Peunova, N. I., Park, J.-H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., & Enikolopov, G. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.03.010 · Cited by 882 · see citing works
Human Adult Neurogenesis: Evidence and Remaining Questions
Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.004 · Cited by 790 · see citing works
Self-citationBoldrini, M., Hen, R., Underwood, M. D., Rosoklija, G. B., Dwork, A. J., Mann, J. J., & Arango, V. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.024 · Cited by 348 · see citing works
Self-citationBraun, N., Papadopoulos, T., & Müller‐Hermelink, H. K. (1988) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02889998 · Cited by 119 · see citing works
Does Adult Neurogenesis Persist in the Human Hippocampus?
Paredes, M. F., Sorrells, S. F., Cebrián‐Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J. W., Auguste, K. I., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.11.006 · Cited by 115 · see citing works
Lopez‐Picon, F. R., Uusi‐Oukari, M., & Holopainen, I. E. (2003) · Hippocampus · doi:10.1002/hipo.10122 · Cited by 25 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Hattiangady B, and Shetty AK (2008). Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol. Aging 29, 129– 147. 17092610 PMC3612500
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Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients
Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603 · see citing works
Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408 · see citing works
“throughout adulthood using double immunofluorescence [20, 98–100], in situ hybridization [101] and (14)C decay-defined neuronal age [102].”
MethodSelf-citationAging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246 · see citing works
Familial Alzheimer’s disease mutations in PSEN1 lead to premature human stem cell neurogenesis
Arber, C., Lovejoy, C., Harris, L., Willumsen, N., Alatza, A., Casey, J. M., Lines, G., Kerins, C., Mueller, A. K., Zetterberg, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108615 · Cited by 116 · see citing works
Unraveling human adult hippocampal neurogenesis
Flor-García, M., Terreros-Roncal, J., Moreno-Jiménez, E. P., Ávila, J., Rábano, A., & Llorens-Martín, M. (2020) · Nature Protocols · doi:10.1038/s41596-019-0267-y · Cited by 113 · see citing works
Mendez‐David, I., David, D. J., Deloménie, C., Tritschler, L., Beaulieu, J., Colle, R., Corruble, E., Gardier, A. M., & Hen, R. (2023) · Hippocampus · doi:10.1002/hipo.23568 · Cited by 15 · see citing works
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- Authors
- Tartt, A. N., Fulmore, C. A., Liu, Y., Rosoklija, G. B., Dwork, A. J., Arango, V., Hen, R., Mann, J. J., & Boldrini, M.
- Affiliations
- New York State Psychiatric Institute (US)
- Macedonian Academy of Sciences and Arts (MK)
- Columbia University (US)
- Corresponding author
- Boldrini, Maura
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 23
- Issue
- 6
- Pages
- 782-783
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC6830306
- OpenAlex
- W2905095341
- Cited by
- 69
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 17 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Stroud Center for Aging Studies at Columbia University
- NIH (MH83862, MH64168, MH40210, NS090415, MH94888, MH090964, MH098786)
- American Foundation for Suicide Prevention (SRG-0-129-12)
- Brain and Behavior Research Foundation Independent Investigator Grant (56388)
- New York Stem Cell Initiative (C029157, C023054)
- Diane Goldberg Foundation
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult hippocampal neurogenesis, brain aging, dentate gyrus, subgranular zone, adult-born neurons, human brain, cancer patients
- MeSH terms
- Adult, Brain, Hippocampus, Humans, Neurogenesis
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