Aging and Rejuvenation of Neural Stem Cells and Their Niches
Open accessAbstract
Aging has a profound and devastating effect on the brain. Old age is accompanied by declining cognitive function and enhanced risk of brain diseases, including cancer and neurodegenerative disorders. A key question is whether cells with regenerative potential contribute to brain health and even brain "rejuvenation." This review discusses mechanisms that regulate neural stem cells (NSCs) during aging, focusing on the effect of metabolism, genetic regulation, and the surrounding niche. We also explore emerging rejuvenating strategies for old NSCs. Finally, we consider how new technologies may help harness NSCs' potential to restore healthy brain function during physiological and pathological aging.
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Ageing leads to a decline in tissue stem cell function.
“Ageing leads to a decline in tissue stem cell function3–5.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [4]
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- Authors
- Navarro Negredo, P., Yeo, R. W., & Brunet, A.
- Affiliations
- Stanford University (US)
- Corresponding author
- Brunet, Anne
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 27
- Issue
- 2
- Pages
- 202-223
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC7415725
- OpenAlex
- W3045630140
- Cited by
- 246
- References
- 271
- Citations by year
- 2026: 31 · 2025: 50 · 2024: 54 · 2023: 48 · 2022: 40 · 2021: 21 · 2020: 2
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Funders
- NIH (P01 AG036695, R01AG056290)
- Glenn Laboratories for the Biology of Aging
- long-term fellowship (LT000136/2018)
- Stanford
- Genentech Foundation
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neural stem cells, brain aging, neural stem cell niche, brain rejuvenation, stem cell metabolism, cognitive decline, neurodegenerative diseases, brain cancer, regenerative capacity
- MeSH terms
- Brain, Rejuvenation, Stem Cell Niche, Neural Stem Cells
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