Cited by 246Neurogenesis and neuroplasticity mechanismsMesenchymal stem cell researchNeuroinflammation and Neurodegeneration Mechanisms

Aging and Rejuvenation of Neural Stem Cells and Their Niches

Open access
Navarro Negredo, Paloma, Yeo, Robin W., Brunet, Anne·2020·Cell Stem Cell

Abstract

Aging has a profound and devastating effect on the brain. Old age is accompanied by declining cognitive function and enhanced risk of brain diseases, including cancer and neurodegenerative disorders. A key question is whether cells with regenerative potential contribute to brain health and even brain "rejuvenation." This review discusses mechanisms that regulate neural stem cells (NSCs) during aging, focusing on the effect of metabolism, genetic regulation, and the surrounding niche. We also explore emerging rejuvenating strategies for old NSCs. Finally, we consider how new technologies may help harness NSCs' potential to restore healthy brain function during physiological and pathological aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.stem.2020.07.002

Cites

270 of 270 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 271 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Navarro Negredo, P., Yeo, R. W., & Brunet, A.
Affiliations
Stanford University (US)
Corresponding author
Brunet, Anne
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2020-08
Volume
27
Issue
2
Pages
202-223
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W3045630140
Cited by
246
References
271
Citations by year
2026: 31 · 2025: 50 · 2024: 54 · 2023: 48 · 2022: 40 · 2021: 21 · 2020: 2
FWCI
4.32
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Funders
  • NIH (P01 AG036695, R01AG056290)
  • Glenn Laboratories for the Biology of Aging
  • long-term fellowship (LT000136/2018)
  • Stanford
  • Genentech Foundation
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neural stem cells, brain aging, neural stem cell niche, brain rejuvenation, stem cell metabolism, cognitive decline, neurodegenerative diseases, brain cancer, regenerative capacity
MeSH terms
Brain, Rejuvenation, Stem Cell Niche, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review