Human Adult Neurogenesis: Evidence and Remaining Questions
Open accessAbstract
Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.
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Adult hippocampal neurogenesis appears to occur in humans as well as in rodents, although this idea is still controversial.
“Adult hippocampal neurogenesis appears to occur in humans as well as in rodents, although this idea is still controversial (36, 37).”
From IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis (2021) · cites this paper as [37]
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Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Self-citationAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Self-citationHuman hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422 · see citing works
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345 · see citing works
Self-citationEnhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
Neurogenesis in the striatum of the adult human brain
Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937 · see citing works
Self-citationA Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works
Self-citationOSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830 · see citing works
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650 · see citing works
Self-citationIncreased cell proliferation and neurogenesis in the adult human Huntington's disease brain
Curtis, M. A., Penney, E. B., Pearson, A. G., van Roon‐Mom, W., Butterworth, N. J., Dragunow, M., Connor, B. J., & Faull, R. L. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1532244100 · Cited by 522 · see citing works
Self-citationLimits of Neurogenesis in Primates
RAKIC, P. T. (1985) · Science · doi:10.1126/science.3975601 · Cited by 503 · see citing works
Progenitor cells from human brain after death
Palmer, T. D., Schwartz, P. H., Taupin, P., Kaspar, B. K., Stein, S. A., & Gage, F. H. (2001) · Nature · doi:10.1038/35075141 · Cited by 457 · see citing works
Self-citationSnyder, J. S., Choe, J. S., Clifford, M. A., Jeurling, S. I., Hurley, P., Brown, A., Kamhi, J. F., & Cameron, H. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1768-09.2009 · Cited by 427 · see citing works
Self-citationFunctions and Dysfunctions of Adult Hippocampal Neurogenesis
Christian, K. M., Song, H., & Ming, G. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014134 · Cited by 395 · see citing works
Self-citationUnique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons
Marín‐Burgin, A., Mongiat, L. A., Pardi, M. B., & Schinder, A. F. (2012) · Science · doi:10.1126/science.1214956 · Cited by 367 · see citing works
Self-citationBoekhoorn, K., Joëls, M., & Lucassen, P. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.017 · Cited by 325 · see citing works
Self-citationHuman adult neurogenesis across the ages: An immunohistochemical study
Dennis, C. V., Suh, L. S., Rodriguez, M. L., Kril, J. J., & Sutherland, G. T. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12337 · Cited by 265 · see citing works
New neurons for 'survival of the fittest'
Kempermann, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3319 · Cited by 236 · see citing works
Self-citationKohler, S. J., Williams, N. I., Stanton, G. B., Cameron, J. L., & Greenough, W. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017099108 · Cited by 178 · see citing works
Coras, R., Siebzehnrübl, F. A., Pauli, E., Huttner, H. B., Njunting, M., Kobow, K., Villmann, C., Hahnen, E., Neuhuber, W., Weigel, D., et al. (2010) · Brain · doi:10.1093/brain/awq215 · Cited by 178 · see citing works
Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021303 · Cited by 166 · see citing works
The age and genomic integrity of neurons after cortical stroke in humans
Huttner, H. B., Bergmann, O., Salehpour, M., Rácz, Á., Tatarishvili, J., Lindgren, E. B., Csonka, T., Csiba, L., Hortobágyi, T., Méhes, G., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3706 · Cited by 127 · see citing works
Self-citationEvidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
Mathews, K. J., Allen, K. M., Boerrigter, D., Ball, H. J., Weickert, C. S., & Double, K. L. (2017) · Aging Cell · doi:10.1111/acel.12641 · Cited by 123 · see citing works
Interaction between Neurogenesis and Hippocampal Memory System: New VistasPreprint
Abrous, D. N., & Wojtowicz, J. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018952 · Cited by 121 · see citing works
Self-citationDoublecortin expression in the normal and epileptic adult human brain
Liu, Y. W. J., Curtis, M. A., Gibbons, H. M., Mee, E. T., Bergin, P., Teoh, H. H., Connor, B. J., Dragunow, M., & Faull, R. L. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06518.x · Cited by 111 · see citing works
Self-citationThe cell cycle–apoptosis connection revisited in the adult brain
Bauer, Š., & Patterson, P. H. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505072 · Cited by 98 · see citing works
Detection and Phenotypic Characterization of Adult NeurogenesisPreprint
Kuhn, H. G., Eisch, A. J., Spalding, K. L., & Peterson, D. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a025981 · Cited by 74 · see citing works
Self-citationGalán, L., Gómez‐Pinedo, U., Guerrero, A., et al. (2017) · BMC Neurology · doi:10.1186/s12883-017-0956-5 · Cited by 60 · see citing works
Amrein, I., & Slomianka, L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.075 · Cited by 45 · see citing works
Chawana, R., Alagaili, A. N., Patzke, N., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.063 · Cited by 30 · see citing works
The art of matching brain tissue from patients and controls for postmortem research
Bao, A., & Swaab, D. F. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00015-3 · Cited by 29 · see citing works
Doublecortin Knockout Mice Show Normal Hippocampal-Dependent Memory Despite CA3 Lamination Defects
Germain, J., Bruel‐Jungerman, E., Grannec, G., Denis, C., Lepousez, G., Bruno Giros, A., Francis, F., & Nosten‐Bertrand, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074992 · Cited by 22 · see citing works
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Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603 · see citing works
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works
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Kalamakis, G., Brüne, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., Stiehl, T., Catalá-Martinez, F., Kupke, J., Zhao, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.040 · Cited by 399 · see citing works
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Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330 · see citing works
Franjic, D., Skarica, M., Ma, S., Arellano, J. I., Tebbenkamp, A. T. N., Choi, J., Xu, C., Li, Q., Morozov, Y. M., Andrijevic, D., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.10.036 · Cited by 308 · see citing works
Micheli, L., Ceccarelli, M., D’Andrea, G., & Tirone, F. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.09.002 · Cited by 288 · see citing works
IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis
Zhang, J., Rong, P., Zhang, L., He, H., Zhou, T., Fan, Y., Mo, L., Zhao, Q., Han, Y., Li, S., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb9888 · Cited by 287 · see citing works
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.010 · Cited by 267 · see citing works
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Zhang, K., Wang, F., Zhai, M., He, M., Hu, Y., Feng, L., Li, Y., Yang, J., & Wu, C. (2023) · Theranostics · doi:10.7150/thno.81067 · Cited by 217 · see citing works
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Arber, C., Lovejoy, C., Harris, L., Willumsen, N., Alatza, A., Casey, J. M., Lines, G., Kerins, C., Mueller, A. K., Zetterberg, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108615 · Cited by 116 · see citing works
Boldrini, M., Galfalvy, H., Dwork, A. J., Rosoklija, G. B., Trencevska-Ivanovska, I., Pavlovski, G., Hen, R., Arango, V., & Mann, J. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.022 · Cited by 116 · see citing works
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Tartt, A. N., Fulmore, C. A., Liu, Y., Rosoklija, G. B., Dwork, A. J., Arango, V., Hen, R., Mann, J. J., & Boldrini, M. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.025 · Cited by 69 · see citing works
Self-citationDuque, A., Arellano, J. I., & Rakic, P. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01314-8 · Cited by 63 · see citing works
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Buntwal, L., Sassi, M., Morgan, A. H., Andrews, Z. B., & Davies, J. S. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.07.001 · Cited by 55 · see citing works
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Maybury‐Lewis, S. Y., Brown, A. K., Yeary, M., Sloutskin, A., Dhakal, S., Juven‐Gershon, T., & Webb, A. E. (2021) · Aging Cell · doi:10.1111/acel.13499 · Cited by 27 · see citing works
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- Authors
- Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Gould, E., Hen, R., Abrous, D. N., Toni, N., Schinder, A. F., Zhao, X., Lucassen, P. J., & Frisén, J.
- Affiliations
- Center for Regenerative Therapies Dresden (DE)
- Salk Institute for Biological Studies (US)
- Paracelsus Medical University (AT)
- University of Pennsylvania (US)
- University of Auckland (NZ)
- King's College London (GB)
- NeuroCure Cluster of Excellence (DE)
- University of Zurich (CH)
- Hospital for Sick Children (CA)
- National Institutes of Health (US)
- Princeton University (US)
- Inserm (FR)
- Centre Hospitalier Universitaire Vaudois (CH)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- University of Wisconsin–Madison (US)
- University of Amsterdam (NL)
- Karolinska Institutet (SE)
- Corresponding author
- Kempermann, Gerd
- Gage, Fred H.
- Frisén, Jonas
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 23
- Issue
- 1
- Pages
- 25-30
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC6035081
- OpenAlex
- W2801769333
- Cited by
- 790
- References
- 33
- Citations by year
- 2026: 40 · 2025: 64 · 2024: 91 · 2023: 92 · 2022: 102 · 2021: 107 · 2020: 122 · 2019: 120 · 2018: 51
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- IRIS (submittedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- DZNE Pub (submittedVersion, other-oa)
- Conicet (submittedVersion, cc-by-nc-sa)
- SERVAL (Université de Lausanne) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Intramural Research Program of the NIMH (ZIAMH002784)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, human hippocampus, neuroplasticity, cognition, lifespan
- MeSH terms
- Adult, Hippocampus, Humans, Neuronal Plasticity, Neurons, Neurogenesis
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