Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.

Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works

Model-based Analysis of ChIP-Seq (MACS)

Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

The I-TASSER Suite: protein structure and function prediction

Yang, J., Yan, R., Roy, A., Xu, D., Poisson, J., & Zhang, Y. (2015) · Nature Methods · doi:10.1038/nmeth.3213 · Cited by 5,596 · see citing works

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works

mTOR at the nexus of nutrition, growth, ageing and disease

Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737 · see citing works

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Li, W., Xu, H., Xiao, T., Cong, L., Love, M. I., Zhang, F., Irizarry, R. A., Liu, J. S., Brown, M., & Liu, X. S. (2014) · Genome Biology · doi:10.1186/s13059-014-0554-4 · Cited by 2,684 · see citing works

A Gene Network Regulating Lysosomal Biogenesis and Function

Sardiello, M., Palmieri, M., di Ronza, A., Medina, D. L., Valenza, M., Gennarino, V. A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R. S., et al. (2009) · Science · doi:10.1126/science.1174447 · Cited by 2,543 · see citing works

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

Čermák, T., Doyle, E., Christian, M. L., Wang, L., Zhang, Y., Schmidt, C. L., Baller, J. A., Somia, N. V., Bogdanove, A. J., & Voytas, D. F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr218 · Cited by 2,034 · see citing works

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Ferron, M., Karsenty, G., Vellard, M. C., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.32 · Cited by 1,932 · see citing works

Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.

Allen, R. C., Zoghbi, H. Y., Moseley, A., Rosenblatt, H. M., & Belmont, J. W. (1992) · PubMed · Cited by 1,683 · see citing works

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Roczniak-Ferguson, A., Petit, C. S. V., Froehlich, F., Qian, S., Ky, J., Angarola, B. L., Walther, T. C., & Ferguson, S. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002790 · Cited by 1,358 · see citing works

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.

Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., & Saitou, M. (2011) · Cell · doi:10.1016/j.cell.2011.06.052 · Cited by 1,324 · see citing works

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1232044 · Cited by 1,080 · see citing works

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

Koike-Yusa, H., Li, Y., Tan, E.-P., Velasco-Herrera, M. D. C., & Yusa, K. (2014) · Nature Biotechnology · doi:10.1038/nbt.2800 · Cited by 1,064 · see citing works

Derivation of novel human ground state naive pluripotent stem cells

Gafni, O., Weinberger, L., Mansour, A. A., Manor, Y. S., Chomsky, E., Ben‐Yosef, D., Kalma, Y., Viukov, S. V., Maza, I., Zviran, A., et al. (2013) · Nature · doi:10.1038/nature12745 · Cited by 1,039 · see citing works

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Bar-Peled, L., Schweitzer, L. D., Zoncu, R., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.07.032 · Cited by 918 · see citing works

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

Martina, J. A., Diab, H. I., Lishu, L., Jeong-A, L., Patange, S., Raben, N., & Puertollano, R. (2014) · Science Signaling · doi:10.1126/scisignal.2004754 · Cited by 677 · see citing works

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells

Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M., Levy, G., Barasch, D., Nemirovski, A., Shen-Orr, S., Laevsky, I., Amit, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.002 · Cited by 666 · see citing works

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., & Yamanaka, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6710-6718.2004 · Cited by 620 · see citing works

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.016 · Cited by 565 · see citing works

Reorganization of enhancer patterns in transition from naive to primed pluripotency

Buecker, C., Srinivasan, R., Wu, Z., Calo, E., Acampora, D., Faial, T., Simeone, A., Tan, M., Swigut, T., & Wysocka, J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.003 · Cited by 507 · see citing works

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

Baba, M., Hong, S., Sharma, N. D., Warren, M. B., Nickerson, M. L., Iwamatsu, A., Esposito, D., Gillette, W., Hopkins, R. F., Hartley, J. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603781103 · Cited by 490 · see citing works

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

Gangloff, Y.-G., Mueller, M., Dann, S. G., Svoboda, P., Sticker, M., Spetz, J.-F., Um, S. H., Brown, E. J., Cereghini, S., Thomas, G., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9508-9516.2004 · Cited by 485 · see citing works

Regulation of TFEB and V‐ATPases by mTORC1

Peña‐Llopis, S., Vega-Rubín-de-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X., Corey, D. R., & Brugarolas, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.257 · Cited by 456 · see citing works

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

Grabiner, B. C., Nardi, V., Birsoy, K., Possemato, R., Shen, K., Sinha, S., Jordan, A. C., Beck, A. H., & Sabatini, D. M. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0929 · Cited by 454 · see citing works

Formative pluripotency: the executive phase in a developmental continuum

Smith, A. G. (2017) · Development · doi:10.1242/dev.142679 · Cited by 449 · see citing works

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

Raben, N., & Puertollano, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125407 · Cited by 437 · see citing works

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

Boroviak, T., Loos, R., Lombard, P., Okahara, J., Behr, R., Sasaki, E., Nichols, J., Smith, A. G., & Bertone, P. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.10.011 · Cited by 421 · see citing works

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

Demetriades, C., Doumpas, N., & Teleman, A. A. (2014) · Cell · doi:10.1016/j.cell.2014.01.024 · Cited by 412 · see citing works

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

Dorighi, K. M., Swigut, T., Henriques, T., Bhanu, N. V., Scruggs, B. S., Nady, N., Still, C. D., Garcia, B. A., Adelman, K., & Wysocka, J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.018 · Cited by 403 · see citing works

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

Petit, C. S., Roczniak-Ferguson, A., & Ferguson, S. M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201307084 · Cited by 355 · see citing works

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

Martina, J. A., & Puertollano, R. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201209135 · Cited by 350 · see citing works

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

Nada, S., Hondo, A., Kasai, A., Koike, M., Saito, K., Uchiyama, Y., & Okada, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.308 · Cited by 341 · see citing works

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

Betschinger, J., Nichols, J., Dietmann, S., Corrin, P. D., Paddison, P. J., & Smith, A. G. (2013) · Cell · doi:10.1016/j.cell.2013.03.012 · Cited by 335 · see citing works

QuasR: quantification and annotation of short reads in R

Gaidatzis, D., Lerch, A., Hahne, F., & Stadler, M. B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu781 · Cited by 316 · see citing works

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers

KAUFFMAN, E. C., Ricketts, C. J., Rais‐Bahrami, S., Yang, Y., Merino, M. J., Bottaro, D. P., Srinivasan, R., & Linehan, W. M. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.162 · Cited by 309 · see citing works

Inhibition of mTOR induces a paused pluripotent state

Bulut-Karslioglu, A., Biechele, S., Jin, H., Macrae, T. A., Hejna, M., Gertsenstein, M., Song, J. S., & Ramalho-Santos, M. (2016) · Nature · doi:10.1038/nature20578 · Cited by 283 · see citing works

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

Čermák, T., Doyle, E., Christian, M., Wang, L., Zhang, Y., Schmidt, C., Baller, J. A., Somia, N. V., Bogdanove, A. J., & Voytas, D. F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr739 · Cited by 281 · see citing works

Tracking the embryonic stem cell transition from ground state pluripotency

Kalkan, T., Olova, N. N., Roode, M., Mulas, C., Lee, H. J., Nett, I., Marks, H., Walker, R. V., Stunnenberg, H. G., Lilley, K. S., et al. (2017) · Development · doi:10.1242/dev.142711 · Cited by 281 · see citing works

A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation

Sampath, P., Pritchard, D. K., Pabon, L., Reinecke, H., Schwartz, S. M., Morris, D. R., & Murry, C. E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.03.013 · Cited by 277 · see citing works

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, Á. M., Baumgärtner, D., Carnevalli, L. S., Atzberger, A., Haas, S., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.033 · Cited by 271 · see citing works

Wide spectrum of developmental brain disorders from megalencephaly to focal cortical dysplasia and pigmentary mosaicism caused by mutations of MTOR

Mirzaa, G., Campbell, C., Solovieff, N., Goold, C. P., Jansen, L., Menon, S., Timms, A., Conti, V., Biag, J., Adams, C., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0363 · Cited by 246 · see citing works

Neural Differentiation of Embryonic Stem Cells In Vitro: A Road Map to Neurogenesis in the Embryo

Abranches, E., Silva, M. R., Pradier, L., Schulz, H., Hummel, O., Henrique, D., & Bekman, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006286 · Cited by 225 · see citing works

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

Ostapcuk, V., Mohn, F., Carl, S. H., Basters, A., Heß, D., Iešmantavičius, V., Lampersberger, L., Flemr, M., Pandey, A., Thomä, N. H., et al. (2018) · Nature · doi:10.1038/s41586-018-0153-8 · Cited by 221 · see citing works

Genetic Basis of Brain Malformations

Parrini, E., Conti, V., Dobyns, W. B., & Guerrini, R. (2016) · Molecular Syndromology · doi:10.1159/000448639 · Cited by 210 · see citing works

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.

Kurimoto, K., Yabuta, Y., Hayashi, K., Ohta, H., Kiyonari, H., Mitani, T., Moritoki, Y., Kohri, K., Kimura, H., Yamamoto, T., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.03.002 · Cited by 182 · see citing works

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Hwang, I.-Y., Kwak, S., Lee, S., Kim, H., Lee, S. E., Kim, J.-H., Kim, Y. A., Jeon, Y. K., Chung, D. H., Jin, X., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.014 · Cited by 180 · see citing works

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomesPreprint

Young, N. P., Kamireddy, A., Nostrand, J. L. V., Eichner, L. J., Shokhirev, M. N., Dayn, Y., & Shaw, R. J. (2016) · Genes & Development · doi:10.1101/gad.274142.115 · Cited by 177 · see citing works

Metabolism in Pluripotent Stem Cells and Early Mammalian Development

Zhang, J., Zhao, J., Dahan, P., Lu, V., Zhang, C., Li, H., & Teitell, M. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.008 · Cited by 163 · see citing works

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissuePreprint

Wada, S., Neinast, M. D., Jang, C., Ibrahim, Y. H., Lee, G., Babu, A., Li, J., Hoshino, A., Rowe, G. C., Rhee, J., et al. (2016) · Genes & Development · doi:10.1101/gad.287953.116 · Cited by 135 · see citing works

Hypomelanosis of Ito: A Description, Not a Diagnosis

Sybert, V. P. (1994) · Journal of Investigative Dermatology · doi:10.1038/jid.1994.26 · Cited by 112 · see citing works

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

Shen, K., Choe, A., & Sabatini, D. M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.026 · Cited by 101 · see citing works

Single-Step Generation of Conditional Knockout Mouse Embryonic Stem Cells

Flemr, M., & Bühler, M. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.051 · Cited by 89 · see citing works

Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution

Li, M., Yu, J. S. L., Tilgner, K., Ong, S., Koike-Yusa, H., & Yusa, K. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.027 · Cited by 81 · see citing works

GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids

Meng, J.-G., & Ferguson, S. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201712177 · Cited by 70 · see citing works

Vacuolin‐1 inhibits autophagy by impairing lysosomal maturation via PIK fyve inhibition

Sano, O., Kazetani, K., Funata, M., Fukuda, Y., Matsui, J., & Iwata, H. (2016) · FEBS Letters · doi:10.1002/1873-3468.12195 · Cited by 62 · see citing works

TFEB regulates murine liver cell fate during development and regeneration

Pastore, N., Huynh, T., Herz, N. J., Calcagnì, A., Klisch, T. J., Brunetti, L., Kim, K. H., Giorgi, M. D., Hurley, A. E., Carissimo, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16300-x · Cited by 51 · see citing works

Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2

Mayer, D., Stadler, M. B., Rittirsch, M., Heß, D., Lukonin, I., Winzi, M., Smith, A. G., Buchholz, F., & Betschinger, J. (2019) · The EMBO Journal · doi:10.15252/embj.2019102591 · Cited by 31 · see citing works

Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway

Piao, X., Kobayashi, T., Wang, L., Shiono, M., Takagi, Y., Sun, G., Abe, M., Hagiwara, Y., Zhang, D., Okimoto, K., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.070 · Cited by 28 · see citing works

Folliculin Interacting Protein-1 Maintains Metabolic Homeostasis During B Cell Development by Modulating AMPK, mTORC1, and TFE3

Ramírez, J., Iwata, T., Park, H., Tsang, M., Kang, J., Cui, K., Kwong, W., James, R. G., Baba, M., Schmidt, L., et al. (2019) · Journal of Immunology · doi:10.4049/jimmunol.1900395 · Cited by 24 · see citing works

Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression

Nagashima, K., Fukushima, H., Shimizu, K., Yamada, A., Hidaka, M., Hasumi, H., Ikebe, T., Fukumoto, S., Okabe, K., & Inuzuka, H. (2016) · Oncotarget · doi:10.18632/oncotarget.14221 · Cited by 16 · see citing works

Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout

Yang, B., Kuang, J., Wu, C., Zhou, W., Zhu, S., Jiang, H., Zhai, Z., Wu, Y., Peng, J., Liu, N., et al. (2020) · Stem Cells International · doi:10.1155/2020/8483035 · Cited by 15 · see citing works

Charting Developmental Dissolution of Pluripotency.

Betschinger, J. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.12.017 · Cited by 10 · see citing works

mTOR at the nexus of nutrition, growth, ageing and disease

Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737 · see citing works

Lysosomes as dynamic regulators of cell and organismal homeostasis

Ballabio, A., & Bonifacino, J. S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0185-4 · Cited by 1,469 · see citing works

Evidence for 28 genetic disorders discovered by combining healthcare and research data

Kaplanis, J., Samocha, K. E., Wiel, L., Zhang, Z., Arvai, K. J., Eberhardt, R. Y., Gallone, G., Lelieveld, S. H., Martin, H. C., McRae, J. F., et al. (2020) · Nature · doi:10.1038/s41586-020-2832-5 · Cited by 615 · see citing works

Lysosome biogenesis: Regulation and functions

Yang, C., & Wang, X.-C. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102001 · Cited by 420 · see citing works

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

Malik, N., Ferreira, B. I., Hollstein, P. E., Curtis, S. D., Trefts, E., Novak, S. W., Yu, J., Gilson, R. C., Hellberg, K., Fang, L., et al. (2023) · Science · doi:10.1126/science.abj5559 · Cited by 228 · see citing works

Structural Mechanism of a Rag GTPase Activation Checkpoint by the Lysosomal Folliculin Complex

Lawrence, R., Fromm, S., Fu, Y.-X., Yokom, A., Kim, D. J., Thelen, A. M., Young, L. N., Lim, C.-Y., Samelson, A. J., Hurley, J., et al. (2019) · Science · doi:10.1126/science.aax0364 · Cited by 169 · see citing works

p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth

Nowosad, A., Jeannot, P., Callot, C., Creff, J., Perchey, R. T., Joffre, C., Codogno, P., Manenti, S., & Besson, A. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0554-4 · Cited by 144 · see citing works

Defined conditions for propagation and manipulation of mouse embryonic stem cells

Mulas, C., Kalkan, T., von Meyenn, F., Leitch, H. G., Nichols, J., & Smith, A. G. (2019) · Development · doi:10.1242/dev.173146 · Cited by 114 · see citing works

Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

Cornacchia, D., Zhang, C., Zimmer, B., Chung, S. Y., Fan, Y., Soliman, M. A., Tchieu, J. H., Chambers, S. M., Shah, H., Paull, D. J., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.05.001 · Cited by 129 · see citing works

GPNMB expression identifies TSC1 /2/ mTOR ‐associated and MiT family translocation‐driven renal neoplasms

Salles, D. C., Asrani, K. V., Woo, J., Vidotto, T., Liu, H. B., Vidal, I., Matoso, A., Netto, G. J., Argani, P., & Lotan, T. L. (2022) · The Journal of Pathology · doi:10.1002/path.5875 · Cited by 120 · see citing works

Metabolic regulation of the hallmarks of stem cell biology

Jackson, B. T., & Finley, L. W. S. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.01.003 · Cited by 122 · see citing works

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency

Kalkan, T., Bornelöv, S., Mulas, C., Diamanti, E., Lohoff, T., Ralser, M., Middelkamp, S., Lombard, P., Nichols, J., & Smith, A. G. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.03.017 · Cited by 119 · see citing works

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Alesi, N., Akl, E. W., Khabibullin, D., Liu, H.-J., Nidhiry, A. S., Garner, E. R., Filippakis, H., Lam, H. C., Shi, W., Viswanathan, S. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24499-6 · Cited by 102 · see citing works

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways

Ramírez-Reyes, J. M. J., Cuesta, R., & Pause, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.667311 · Cited by 87 · see citing works

MiT/TFE Family of Transcription Factors: An Evolutionary Perspective

Spina, M. L., Contreras, P. S., Rissone, A., Meena, N. K., Jeong, E., & Martina, J. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.609683 · Cited by 91 · see citing works

Defining Human Pluripotency

Yilmaz, A., & Benvenisty, N. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.06.010 · Cited by 87 · see citing works

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

Gollwitzer, P., Grützmacher, N., Wilhelm, S., Kümmel, D., & Demetriades, C. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00976-y · Cited by 73 · see citing works

Genome-wide CRISPR-Cas9 screening in mammalian cells

Yu, J., & Yusa, K. (2019) · Methods · doi:10.1016/j.ymeth.2019.04.015 · Cited by 64 · see citing works

Balancing lysosome abundance in health and disease

Mutvei, A. P., Nagiec, M. J., & Blenis, J. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01197-7 · Cited by 61 · see citing works

scHiClassifier: a deep learning framework for cell type prediction by fusing multiple feature sets from single-cell Hi-C data

Zhou, X., & Wu, H. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf009 · Cited by 60 · see citing works

TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex

Alesi, N., Khabibullin, D., Rosenthal, D. M., Akl, E. W., Cory, P. M., Alchoueiry, M., Salem, S., Daou, M., Gibbons, W. F., Chen, J. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44229-4 · Cited by 58 · see citing works

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

Nardone, C., Palanski, B. A., Scott, D. C., Timms, R. T., Barber, K. W., Gu, X., Mao, A., Leng, Y., Watson, E. V., Schulman, B. A., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.013 · Cited by 50 · see citing works

TFEB regulates murine liver cell fate during development and regeneration

Pastore, N., Huynh, T., Herz, N. J., Calcagnì, A., Klisch, T. J., Brunetti, L., Kim, K. H., Giorgi, M. D., Hurley, A. E., Carissimo, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16300-x · Cited by 51 · see citing works

A Compendium of Information on the Lysosome

Bouhamdani, N., Comeau, D., & Turcotte, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.798262 · Cited by 52 · see citing works

Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking

Sanderson, L. E., Lanko, K., Alsagob, M., Almass, R., Alahmady, N. F., Najafi, M., Al–Muhaizea, M. A., Alzaidan, H., Aldhalaan, H., Perenthaler, E., et al. (2021) · Brain · doi:10.1093/brain/awaa459 · Cited by 51 · see citing works

NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translationPreprint

Huth, M., Santini, L., Galimberti, E., Ramesmayer, J., Titz-Teixeira, F., Sehlke, R., Oberhuemer, M., Stummer, S., Herzog, V., Garmhausen, M., et al. (2022) · Genes & Development · doi:10.1101/gad.347690.120 · Cited by 45 · see citing works

Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency

Lackner, A., Sehlke, R., Garmhausen, M. R., Stirparo, G. G., Huth, M., Titz‐Teixeira, F., van der Lelij, P., Ramesmayer, J., Thomas, H., Ralser, M., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020105776 · Cited by 43 · see citing works

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6

Tsujimoto, K., Jo, T., Nagira, D., Konaka, H., Park, J. H., Yoshimura, S., Ninomiya, A., Sugihara, F., Hirayama, T., Itotagawa, E., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022111389 · Cited by 45 · see citing works

MiT Family Transcriptional Factors in Immune Cell Functions

Kim, S., Song, H.-S., Yu, J., & Kim, Y. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0067 · Cited by 42 · see citing works

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

Hanna, J., David, L. A., Touahri, Y., Fleming, T., Screaton, R. A., & Schuurmans, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.887764 · Cited by 43 · see citing works

An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss

Asrani, K. V., Woo, J., Mendes, A. A. D. A., Schaffer, E. D., Vidotto, T., Villanueva, C. R., Feng, K., Oliveira, L., Murali, S., Liu, H. B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34617-7 · Cited by 41 · see citing works

Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness

Nowosad, A., & Besson, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042290 · Cited by 36 · see citing works

Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency

MacDougall, M. S., Clarke, R., & Merrill, B. J. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.04.015 · Cited by 39 · see citing works

A conserved cysteine‐based redox mechanism sustains TFEB/HLH‐30 activity under persistent stress

Martina, J. A., Guerrero‐Gómez, D., Gómez‐Orte, E., Bárcena, J. A., Cabello, J., Miranda‐Vizuete, A., & Puertollano, R. (2020) · The EMBO Journal · doi:10.15252/embj.2020105793 · Cited by 39 · see citing works

Integrating healthcare and research genetic data empowers the discovery of 28 novel developmental disorders

Kaplanis, J., Samocha, K. E., Wiel, L., Zhang, Z., Arvai, K. J., Eberhardt, R. Y., Gallone, G., Lelieveld, S. H., Martin, H. C., McRae, J. F., et al. (2019) · doi:10.1101/797787 · Cited by 36 · see citing works

Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2

Mayer, D., Stadler, M. B., Rittirsch, M., Heß, D., Lukonin, I., Winzi, M., Smith, A. G., Buchholz, F., & Betschinger, J. (2019) · The EMBO Journal · doi:10.15252/embj.2019102591 · Cited by 31 · see citing works

Electrochemical biosensors for stem cell analysis; applications in diagnostics, differentiation and follow-up

Nasrollahpour, H., Khalilzadeh, B., Naseri, A., Yousefi, H., Erk, N., & Rahbarghazi‬, R. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116696 · Cited by 36 · see citing works

TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis

Tan, A., Prasad, R., & Jho, E. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03632-9 · Cited by 34 · see citing works

Emerging roles of the MiT/TFE factors in cancer

Zoncu, R., & Perera, R. M. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.06.005 · Cited by 32 · see citing works

Organelle Cooperation in Stem Cell Fate: Lysosomes as Emerging Regulators of Cell Identity

Julian, L. M., & Stanford, W. L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00591 · Cited by 32 · see citing works

Clinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities

Carmignac, V., Mignot, C., Blanchard, E., Kuentz, P., Aubriot‐Lorton, M., Parker, V., Sorlin, A., Fraitag, S., Courcet, J.-B., Duffourd, Y., et al. (2021) · Genetics in Medicine · doi:10.1038/s41436-021-01161-6 · Cited by 28 · see citing works

Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes

Lang, M., Pramstaller, P. P., & Pichler, I. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00555-7 · Cited by 34 · see citing works

Molecular Regulators of Embryonic Diapause and Cancer Diapause-like State

Hussein, A. M., Balachandar, N., Mathieu, J., & Ruohola‐Baker, H. (2022) · Cells · doi:10.3390/cells11192929 · Cited by 29 · see citing works

The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoids

Waehle, V., Ungricht, R., Hoppe, P. S., & Betschinger, J. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.07.023 · Cited by 27 · see citing works

Dissection of two routes to naïve pluripotency using different kinase inhibitors

Martínez‐Val, A., Lynch, C. J., Calvo, I., Ximénez‐Embún, P., Garcı́a, F., Zarzuela, E., Serrano, M., & Muñoz, J. (2021) · Nature Communications · doi:10.1038/s41467-021-22181-5 · Cited by 26 · see citing works

Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils

Belliveau, N. M., Footer, M. J., Akdoǧan, E., van Loon, A. P., Collins, S. R., & Theriot, J. (2023) · Nature Communications · doi:10.1038/s41467-023-41452-x · Cited by 22 · see citing works

Folliculin Interacting Protein-1 Maintains Metabolic Homeostasis During B Cell Development by Modulating AMPK, mTORC1, and TFE3

Ramírez, J., Iwata, T., Park, H., Tsang, M., Kang, J., Cui, K., Kwong, W., James, R. G., Baba, M., Schmidt, L., et al. (2019) · Journal of Immunology · doi:10.4049/jimmunol.1900395 · Cited by 24 · see citing works

A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity

Endoh, M., Baba, M., Endoh, T., Hirayama, A., Nakamura‐Ishizu, A., Umemoto, T., Hashimoto, M., Nagashima, K., Soga, T., Lang, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.042 · Cited by 25 · see citing works

mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes.

Zwakenberg, S., Westland, D., van Es, R. V., Rehmann, H., Anink, J., Ciapaite, J., Bosma, M., Stelloo, E., Liv, N., Alcaraz, P. S., et al. (2024) · Molecules and Cells · doi:10.1016/j.molcel.2024.10.009 · Cited by 22 · see citing works

Maintenance of neural stem-progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon

Yuizumi, N., Harada, Y., Kuniya, T., Sunabori, T., Koike, M., Wakabayashi, M., Ishihama, Y., Suzuki, Y., Kawaguchi, D., & Gotoh, Y. (2021) · Stem Cells · doi:10.1002/stem.3359 · Cited by 23 · see citing works

Molecular versatility during pluripotency progression

Furlan, G., Huyghe, A., Combémorel, N., & Lavial, F. (2023) · Nature Communications · doi:10.1038/s41467-022-35775-4 · Cited by 18 · see citing works

Blood and lymphatic systems are segregated by the FLCN tumor suppressor

Tai-Nagara, I., Hasumi, Y., Kusumoto, D., Hasumi, H., Okabe, K., Ando, T., Matsuzaki, F., Itoh, F., Saya, H., Liu, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20156-6 · Cited by 23 · see citing works

Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Immunohistochemistry Can Be a Useful Ancillary Tool to Identify Perivascular Epithelioid Cell Tumor

Wangsiricharoen, S., Ingram, D. R., Morey, R. R., Wani, K., Lazar, A. J., & Wang, W. (2024) · Modern Pathology · doi:10.1016/j.modpat.2024.100426 · Cited by 22 · see citing works

New Developments in the Pathogenesis of Pulmonary Cysts in Birt–Hogg–Dubé Syndrome

Kennedy, J., Khabibullin, D., Boku, Y., Shi, W., & Henske, E. (2020) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0040-1708500 · Cited by 15 · see citing works

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

Santini, L., Kowald, S., Cerron-Alvan, L. M., Huth, M., Fabing, A. P., Sestini, G., Rivron, N. C., & Leeb, M. (2024) · Nature Communications · doi:10.1038/s41467-024-51794-9 · Cited by 21 · see citing works

Transcriptome profile of bovine iPSCs derived from Sertoli Cells

Jiang, Y., An, X.-L., Yu, H., Cai, N., Zhai, Y., Li, Q., Cheng, H., Zhang, S., Tang, B., Li, Z., et al. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.11.022 · Cited by 21 · see citing works

Amino acid intake strategies define pluripotent cell states

Todorova, P. K., Jackson, B. T., Garg, V., Paras, K. I., Brunner, J. S., Bridgeman, A. E., Chen, Y., Baksh, S. C., Yan, J., Hadjantonakis, A., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00940-6 · Cited by 21 · see citing works

The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency

Olivieri, D., Paramanathan, S., Bardet, A. F., Heß, D., Smallwood, S. A., Elling, U., & Betschinger, J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100947 · Cited by 19 · see citing works

The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy

Alhasan, B. A., Gordeev, S. A., Knyazeva, A. R., Aleksandrova, K. V., Margulis, B. A., Guzhova, I. V., & Suvorova, I. I. (2021) · Membranes · doi:10.3390/membranes11110858 · Cited by 18 · see citing works

Lysosomes in glioblastoma: pump up the volume

Jacobs, K. A., Maghe, C., & Gavard, J. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1796016 · Cited by 13 · see citing works

Perspectives of mitochondria-lysosome-related organelle in hepatocyte dedifferentiation and implications in chronic liver disease

Ma, X., Ni, H., & Ding, W. (2024) · eGastroenterology · doi:10.1136/egastro-2023-100046 · Cited by 17 · see citing works

De novo mutations in the X-linked TFE3 gene cause intellectual disability with pigmentary mosaicism and storage disorder-like features

Lehalle, D., Vabres, P., Sorlin, A., Bierhals, T., Avila, M., Carmignac, V., Chevarin, M., Torti, E. E., Abe, Y., Bartolomaeus, T., et al. (2020) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2019-106508 · Cited by 16 · see citing works

Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout

Yang, B., Kuang, J., Wu, C., Zhou, W., Zhu, S., Jiang, H., Zhai, Z., Wu, Y., Peng, J., Liu, N., et al. (2020) · Stem Cells International · doi:10.1155/2020/8483035 · Cited by 15 · see citing works

High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development

Krumm, J., Sekine, K., Samaras, P., Brazovskaja, A., Breunig, M., Yasui, R., Kleger, A., Taniguchi, H., Wilhelm, M., Treutlein, B., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110604 · Cited by 15 · see citing works

Cooperation between HDAC3 and DAX1 mediates lineage restriction of embryonic stem cells

Olivieri, D., Castelli, E., Kawamura, Y., Papasaikas, P., Lukonin, I., Rittirsch, M., Heß, D., Smallwood, S. A., Stadler, M. B., Peters, A. H. F. M., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106818 · Cited by 13 · see citing works

<i>TFE3</i>‐associated neurodevelopmental disorder: A distinct recognizable syndrome

Diaz, J., Berger, S., & Leon, E. (2020) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61437 · Cited by 14 · see citing works

TFE3 Rearrangement and Expression in Renal Cell Carcinoma

Kmeid, M., & Akgül, M. (2022) · International Journal of Surgical Pathology · doi:10.1177/10668969221108517 · Cited by 14 · see citing works

Srebf1c preserves hematopoietic stem cell function and survival as a switch of mitochondrial metabolism

Lu, Y., Zhang, Z., Wang, S., Qi, Y., Chen, F., Xu, Y., Shen, M., Chen, M., Chen, N., Yang, L., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.01.011 · Cited by 14 · see citing works

NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover

Liu, B., Hua, D., Shen, L., Li, T., Tao, Z., Fu, C., Tang, Z., Yang, J., Zhang, L., Nie, A., et al. (2024) · Theranostics · doi:10.7150/thno.90946 · Cited by 13 · see citing works

Genome-wide functional genomics screens identify therapeutic vulnerabilities for lymphangioleiomyomatosisPreprint

Camacho‐Magallanes, A., Delaney, S. P., Lian, E. Y., Wiljer, E., Yockell‐Lelièvre, J., Julian, L. M., Pietrobon, A., Batoff, W., Kristof, A. S., & Stanford, W. L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/683359 · Cited by 12 · see citing works

Implications of Altered Endosome and Lysosome Biology in Space Environments

Johnson, I. R. D., Nguyen, C. T., Wise, P. M., & Grimm, D. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218205 · Cited by 11 · see citing works

Generation of mouse–human chimeric embryos

Zhang, B., Li, H., Hu, Z., Jiang, H., Stablewski, A. B., Marzullo, B. J., Yergeau, D. A., & Feng, J. (2021) · Nature Protocols · doi:10.1038/s41596-021-00565-7 · Cited by 11 · see citing works

Combinatorial metabolism drives the naive to primed pluripotent chromatin landscape

Ehnes, D. D., Hussein, A. M., Ware, C. B., Mathieu, J., & Ruohola‐Baker, H. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111913 · Cited by 10 · see citing works

Research and Therapeutic Approaches in Stem Cell Genome Editing by CRISPR Toolkit

Mollashahi, B., Latifi‐Navid, H., Owliaee, I., Shamdani, S., Uzan, G., Jamehdor, S., & Naserian, S. (2023) · Molecules · doi:10.3390/molecules28041982 · Cited by 11 · see citing works

A novel pathogenic RHOA variant in a patient with patterned cutaneous hypopigmentation associated with extracutaneous findings

Cai, Z. R., McCuaig, C. C., Hatami, A., Rivière, J., & Marcoux, D. (2022) · Pediatric Dermatology · doi:10.1111/pde.14923 · Cited by 9 · see citing works

Transcription Factor EB-Mediated Lysosomal Function Regulation for Determining Stem Cell Fate under Metabolic Stress

Chae, C. W., Jung, Y. H., & Han, H. J. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0143 · Cited by 8 · see citing works

The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT‐TFE3 pathway in C2C12 myoblasts

Osana, S., Kitajima, Y., Naoki, S., Murayama, K., Takada, H., Tabuchi, A., Kano, Y., & Nagatomi, R. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31070 · Cited by 8 · see citing works

Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes

Qiu, J., & Ghaffari, S. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.07.299 · Cited by 7 · see citing works

The Spectrum of Renal “TFEopathies”: Flipping the mTOR Switch in Renal Tumorigenesis

Alesi, N., Asrani, K. V., Lotan, T. L., & Henske, E. P. (2024) · Physiology · doi:10.1152/physiol.00026.2024 · Cited by 7 · see citing works

Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification

Aloisio, F. M., & Barber, D. L. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.002 · Cited by 7 · see citing works

Cooperative genetic networks drive a mammalian cell state transitionPreprint

Lackner, A., Sehlke, R., Garmhausen, M., Stirparo, G. G., Huth, M., Titz-Teixeira, F., van der Lelij, P., Ramesmayer, J., Thomas, H. F., Ralser, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.23.000109 · Cited by 7 · see citing works

Autophagy in Xp11 translocation renal cell carcinoma: from bench to bedside

Sun, H., Wei, X., & Zeng, C. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04235-w · Cited by 6 · see citing works

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

Doumpas, N., Söderholm, S., Narula, S., Moreira, S., Doble, B. W., Cantù, C., & Basler, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109705 · Cited by 5 · see citing works

A meiotic switch in lysosome activity supports spermatocyte development in young flies but collapses with age

Butsch, T. J., Dubuisson, O. S., Johnson, A. E., & Bohnert, K. A. (2022) · iScience · doi:10.1016/j.isci.2022.104382 · Cited by 5 · see citing works

Med12 cooperates with multiple differentiation signals to facilitate efficient lineage transitions in embryonic stem cells

Fernkorn, M., & Schröter, C. J. (2025) · Journal of Cell Science · doi:10.1242/jcs.263794 · Cited by 5 · see citing works

Calcium: A New Guardian of Naive Pluripotency

Zhu, Y., & Zhang, J. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.07.004 · Cited by 4 · see citing works

Sclerosing perivascular epithelioid cell tumour (PEComa) of the testis in a patient with tuberous sclerosis complex

Galea, L. A., Hildebrand, M. S., Boys, A., Joy, C., Chee, J. B. L., & White, G. (2022) · Pathology · doi:10.1016/j.pathol.2022.02.012 · Cited by 4 · see citing works

Cell migration CRISPRi screens in human neutrophils reveal regulators of context-dependent migration and differentiation statePreprint

Belliveau, N. M., Footer, M. J., Akdoǧan, E., van Loon, A. P., Collins, S. R., & Theriot, J. (2022) · bioRxiv · doi:10.1101/2022.12.16.520717 · Cited by 2 · see citing works

Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit

Li, Z., Li, X., Lin, J., Wang, Y., Cao, H., & Zhou, J. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2594-3 · Cited by 3 · see citing works

Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons

Wu, H., Cao, L., Wen, X., Fan, J., Wang, Y., Hu, H., Ji, S., Zhang, Y., Ye, C., Xie, W., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.10.018 · Cited by 3 · see citing works

Lysosomes Dare Cells to be Different(iated)

Roczniak-Ferguson, A., & Ferguson, S. M. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.01.007 · Cited by 3 · see citing works

Suppression of transient receptor potential melastatin 7 regulates pluripotency, proliferation, and differentiation of mouse embryonic stem cells via mechanistic target of rapamycin‐extracellular signal‐regulated kinase activation

Kim, W., Park, S., Kwon, W., Kim, D.-H., Park, J., Han, J. E., Cho, G., Han, S., Sung, Y., Yi, J., et al. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30199 · Cited by 3 · see citing works

Pigmentary Mosaicism: An Overview

Colmant, C., Legius, E., Cattaert, N., & Morren, M. (2025) · JEADV Clinical Practice · doi:10.1002/jvc2.70048 · Cited by 2 · see citing works

The pivotal protein profile between the conjoined twins and normal mosquitofish Gambusia affinis based on iTRAQ proteomic analysis

Fan, L., Wang, L., Guo, H., & Zou, J. (2021) · Fish Physiology and Biochemistry · doi:10.1007/s10695-021-00951-8 · Cited by 2 · see citing works

Autophagy in germ cells, stem cells, and induced pluripotent stem cells

Islam, M., Nguyen, N. U. N., Diwan, A., & Rothermel, B. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00028-0 · Cited by 2 · see citing works

Linking lysosomes to stem cell differentiation

VanHook, A. M. (2019) · Science Signaling · doi:10.1126/scisignal.aax0926 · Cited by 2 · see citing works

Repression of lysosomal transcription factors Tfeb and Tfe3 is essential for the migration and function of microgliaPreprint

Iyer, H., Shen, K., Meireles, A. M., & Talbot, W. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.27.357897 · Cited by 2 · see citing works

Hyperactivation of mTORC1 blocks stem cell fate transitions through TFE3-NuRD association

Li, P., Xu, S., Wu, X., Gao, Y., Ahmed, T., Huang, Y., Qin, D., Qin, B., Wang, L., & Xu, X. (2026) · EMBO Reports · doi:10.1038/s44319-025-00544-z · Cited by 1 · see citing works

Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity

Arputhasamy, C., Foulger, A., Lucanic, M., Rane, A., Schmidt, M., Garrett, T., Broussalian, M., Battistoni, E., Brem, R. B., Lithgow, G. J., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00647-8 · Cited by 1 · see citing works

Lysosomal signaling is required for embryonic stem cell differentiation and human development

Villegas, F. (2017) · edoc (University of Basel) · doi:10.5451/unibas-006808294

Mechanisms of pluripotent cell state transitions

Mayer, D. (2019) · edoc (University of Basel) · doi:10.5451/unibas-007171182

Lysosomes Dare Cells to be Different(iated)

Roczniak-Ferguson, A., & Ferguson, S. M. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.01.007 · Cited by 3 · see citing works

Transcription Factor EB-Mediated Lysosomal Function Regulation for Determining Stem Cell Fate under Metabolic Stress

Chae, C. W., Jung, Y. H., & Han, H. J. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0143 · Cited by 8 · see citing works

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

Betschinger, J., Nichols, J., Dietmann, S., Corrin, P. D., Paddison, P. J., & Smith, A. G. (2013) · Cell · doi:10.1016/j.cell.2013.03.012 · Cited by 335 · see citing works