mTOR at the nexus of nutrition, growth, ageing and disease

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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AMPK: guardian of metabolism and mitochondrial homeostasis

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

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The role of autophagy during the early neonatal starvation period

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Mechanism and medical implications of mammalian autophagy

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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The role of autophagy in neurodegenerative disease

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

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Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Termination of autophagy and reformation of lysosomes regulated by mTOR

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De novo mutations in epileptic encephalopathies

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

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A unifying model for mTORC1-mediated regulation of mRNA translation

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

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Regulation of TORC1 by Rag GTPases in nutrient response

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismPreprint

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Sestrin2 is a leucine sensor for the mTORC1 pathway

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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Phosphorylation and Functional Inactivation of TSC2 by Erk

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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

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The mTOR‐regulated phosphoproteome reveals a mechanism of mTORC1‐mediated inhibition of growth factor signaling

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A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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