Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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3. Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer’s Disease Mice
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4. Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture
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5. Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier
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6. Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models
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7. Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer’s Disease
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8. Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation
   Kangshuai Du, Yunxiao Dou, Kui Chen, Yanxin Zhao · 2023 · Experimental Neurology
9. α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance
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10. Cholesterol profiling reveals 7β‐hydroxycholesterol as a pathologically relevant peripheral biomarker of Alzheimer's disease
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11. ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology
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12. APOE4 Exacerbates Cerebral Tau Pathology Through Cholesterol‐Induced Degradation of Phosphatase in Atherosclerosis
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13. Alzheimer's disease: from molecular pathways to therapies
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14. LASER couples damage sensing to ESCRT assembly for lysosome repair
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15. Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice
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16. Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments
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17. Patient-derived iPSCs, a reliable in vitro model for the investigation of Alzheimer’s disease
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19. Recent advances in Alzheimer’s disease: From molecular mechanisms to therapeutic strategies
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22. Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease
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23. Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia
    Moriah J. Hovde, Anna Maaser‐Hecker, Jun‐Seok Bae, Rudolph E. Tanzi · 2025 · Alzheimer s & Dementia
24. Advances in iPSC Technology in Neural Disease Modeling, Drug Screening, and Therapy
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25. Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease
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26. Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
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27. Challenges and Opportunities for Consideration of Efavirenz Drug Repurposing for Alzheimer’s Disease Therapeutics
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28. Calycosin-7-O-β-D-Glucoside Ameliorates Palmitate-Induced Lipid Accumulation in HT22 Cells
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29. Cholesterol and its reciprocal association with prion infection
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31. Comparative gene regulatory networks modulating APOE expression in microglia and astrocytes
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32. Cholesterol Modulation Attenuates the AD-like Phenotype Induced by Herpes Simplex Virus Type 1 Infection
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33. Amyloid‐β but not tau accumulation is strongly associated with longitudinal cognitive decline
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34. Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease
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35. Molecular mechanisms of exercise-induced improvements in Alzheimer’s disease: a focus on lipid homeostasis
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36. The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention?
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37. Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations
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38. Dissection of Neurochemical Pathways Across Complexity and Scale
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39. Potential role of Drug Repositioning Strategy (DRS) for management of tauopathy
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40. Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging
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41. Lipid metabolism in Alzheimer’s disease
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43. Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis
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44. Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission
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45. Fiber-optic SPR cholesterol sensor based on Au film- AuNPs coupling enhancement
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46. Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment
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54. Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
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56. DHCR24 knockdown-induced cellular cholesterol deficiency triggers tau hyperphosphorylation at Thr181, Ser199 and Ser202/Thr205 via p38 MAPK/JNK signaling.
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57. Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice
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