Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

Cited by (352)

Items 101–200 of 352

  1. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease
    Juan Antonio García‐León, Laura Cáceres-Palomo, Elisabeth Sánchez‐Mejías, Marina Mejias‐Ortega, Cristina Nuñez‐Diaz, Juan José Fernandez-Valenzuela, Raquel Maria Sanchez-Varo, José Carlos Dávila, Javier Vitórica, Antonia Gutiérrez · 2020 · International Journal of Molecular Sciences
  2. Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology
    Mu Seog Choe, Han Cheol Yeo, Joong‐Sun Kim, Jean Lee, Hae Jun Lee, Hyung‐Ryong Kim, Kyung Min Baek, Na‐Yeon Jung, Murim Choi, Min Young Lee · 2024 · Stem Cell Research & Therapy
  3. Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes
    Alexey M. Petrov, Natalia Mast, Young Li, John A. Denker, Irina A. Pikuleva · 2020 · Brain Communications
  4. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
    Kloske, Courtney M., Belloy, Michael E., Blue, Elizabeth E., Bowman, Gregory R., Carrillo, Maria C., Chen, Xiaoying, Chiba‐Falek, Ornit, Davis, Albert A., Paolo, Gilbert Di, Garretti, Francesca et al. · 2024 · Alzheimer's & Dementia
  5. The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
    Feringa, Femke M., Koppes-den Hertog, Sascha J., Wang, Lian Y., Derks, Rico J. E., Kruijff, Iris, Erlebach, Lena, Heijneman, Jorin, Miramontes, Ricardo, Pömpner, Nadine, Blomberg, Niek et al. · 2025 · Nature Metabolism
  6. Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo
    Fumihiro Kawagoe, Aileen D.L. Mendoza, Yuki Hayata, Lisa Asano, Kenjiro Kotake, Sayuri Mototani, Satoshi Kawamura, Shigeyuki Kurosaki, Yusuke Akagi, Yasushi Takemoto et al. · 2021 · Journal of Medicinal Chemistry
  7. Lipid Homeostasis and Its Links With Protein Misfolding Diseases
    Michele Vendruscolo · 2022 · Frontiers in Molecular Neuroscience
  8. Cerebrospinal fluid lipidomics: effects of an intravenous triglyceride infusion and apoE status
    Angela J. Hanson, William A. Banks, Lisa Bettcher, Robert H. Pepin, Daniel Raftery, Suzanne Craft · 2019 · Metabolomics
  9. MAM and C99, key players in the pathogenesis of Alzheimer’s disease
    Marta Pera, Jorge Montesinos, Delfina Larrea, Rishi R. Agrawal, KEVIN R. VELASCO, Irina G. Stavrovskaya, Taekyung D. Yun, Estela Área-Gómez · 2020 · International review of neurobiology
  10. New Strategy for Reducing Tau Aggregation Cytologically by A Hairpinlike Molecular Inhibitor, Tannic Acid Encapsulated in Liposome
    Yuan Hu, Xiaochun Hu, Yonglin Lu, Shuo Shi, Danjing Yang, Tianming Yao · 2020 · ACS Chemical Neuroscience
  11. Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease
    Xinjie Guan, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Cheng-Fu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, King‐Ho Cheung, Jiahong Lu, Jieqiong Tan et al. · 2022 · International Journal of Molecular Sciences
  12. Lipidomics analysis in drug discovery and development
    Sarantos Kostidis, Elena Sánchez‐López, Martin A. Giera · 2022 · Current Opinion in Chemical Biology
  13. Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex‐Dependent Manner
    Tianlu Chen, Lu Wang, Guoxiang Xie, Bruce S. Kristal, Xiaojiao Zheng, Tao Sun, Matthias Arnold, Gregory Louie, Mengci Li, Lirong Wu et al. · 2023 · Advanced Science
  14. Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes
    Zhang, Xiaoyu, Chen, Chuanying, Liu, Yi · 2024 · Alzheimer's Research & Therapy
  15. High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice
    Wang, Tao, Zhang, Xiaona, Wang, Yushan, Liu, Wen, Wang, Lijing, Hao, Ling, Ju, Mengwei, Xiao, Rong · 2022 · The Journal of Nutritional Biochemistry
  16. Based on molecular structures: Amyloid-β generation, clearance, toxicity and therapeutic strategies
    Hai Yang, Jin‐Ping Li, Xiaoxiong Li, Linqiu Ma, Mingliang Hou, Huadong Zhou, Rui Zhou · 2022 · Frontiers in Molecular Neuroscience
  17. CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
    María Latorre‐Leal, Patricia Rodriguez‐Rodriguez, Luca Franchini, Orestis Nikolidakis, Makrina Daniilidou, Ljerka Delac, Mukesh Varshney, Luis Enrique Arroyo‐García, Francesca Eroli, Bengt G. Winblad et al. · 2024 · Science Advances
  18. Cholesterol Metabolism in Neurodegenerative Diseases
    Keqiang He, Zhiwei Zhao, Juan Zhang, Dingfeng Li, Sheng Wang, Qiang Liu · 2024 · Antioxidants and Redox Signaling
  19. Plasma cholesterol in Alzheimer’s disease and frontotemporal dementia
    Pan Wang, Huihong Zhang, Yan Wang, Miao Zhang, Yuying Zhou · 2020 · Translational Neuroscience
  20. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction
    Huajun Zhao, Yating Yu, Yucan Wang, Lianhui Zhao, Ailu Yang, Yifei Hu, Zhaoyi Pan, Zixuan Wang, Jiarui Yang, Qiuju Han et al. · 2022 · Cellular and Molecular Immunology
  21. Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation
    Pradeepraj Durairaj, Zixiang Leonardo Liu · 2025 · Journal of Xenobiotics
  22. 27-Hydroxycholesterol Promotes the Transfer of Astrocyte-Derived Cholesterol to Neurons in Co-cultured SH-SY5Y Cells and C6 Cells
    Yushan Wang, Xiaona Zhang, Tao Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xiao · 2020 · Frontiers in Cell and Developmental Biology
  23. Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles
    Lin Bai, Yafei Wang, Jia Huo, Shuai Li, Ya Wen, Qi Liu, Jing Yang, Yaling Liu, Rui Li · 2021 · Cell Death and Disease
  24. Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer’s disease
    Lei, Mona, Teo, Jonathan D., Song, Huitong, McEwen, Holly P., Yup Lee, Jun, Couttas, Timothy A., Duncan, Thomas, Chesworth, Rose, Bertz, Josefine, Przybyla, Magdalena et al. · 2019 · The Journal of Neuroscience
  25. Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes
    Amand Floriaan Schmidt, Roshni Joshi, María Gordillo‐Marañón, Fotios Drenos, Pimphen Charoen, Claudia Giambartolomei, Joshua C. Bis, Tom R. Gaunt, Alun David Hughes, Debbie A. Lawlor et al. · 2023 · Communications Medicine
  26. The Breakthroughs and Caveats of Using Human Pluripotent Stem Cells in Modeling Alzheimer’s Disease
    Katja Maria Bendtsen, Vanessa Jane Hall · 2023 · Cells
  27. Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides
    Harald Frankowski, Fred Yeboah, Bonnie J. Berry, Chizuru Kinoshita, Michelle Lee, Kira M. Evitts, Joshua Davis, Yoshito Kinoshita, Richard S. Morrison, Jessica E. Young · 2021 · International Journal of Molecular Sciences
  28. Blocking cholesterol storage to treat Alzheimer's disease
    Chang, Ta Yuan, Chang, Catherine C. Y., Harned, Taylor C., De La Torre, Adrianna L., Lee, Junghoon, Huynh, Thao N., Gow, James G. · 2021 · Exploration of Neuroprotective Therapy
  29. Potential Value of Serum Lipid in the Identication of Postoperative Delirium Undergoing Knee/Hip Arthroplasty: The Perioperative Neurocognitive Disorder and Biomarker Lifestyle Study
    Yanan Lin, Xiaoyan Peng, Xu Lin, Xiyuan Deng, Fanghao Liu, He Tao, Rui Dong, Bin Wang, Yanlin Bi · 2022 · Frontiers in Psychiatry
  30. Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
    Hany E. S. Marei, Muhammad Umar Aslam Khan, Anwarul Hasan · 2023 · Cellular & Molecular Biology Letters
  31. Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers
    Monica Emili Garcia‐Segura, Brenan R. Durainayagam, Sonia Liggi, Gonçalo Graça, Beatriz Jiménez, Abbas Dehghan, Ioanna Tzoulaki, İbrahim Karaman, Paul Elliott, Julian Leether Griffin · 2022 · Journal of Neurochemistry
  32. Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy
    Jian Zhao, Lulu Jiang, Alex C. Matlock, Yihong Xu, Jiabei Zhu, Hongbo Zhu, Lei Tian, Benjamin L. Wolozin, Ji‐Xin Cheng · 2023 · Light Science & Applications
  33. Cerebrospinal fluid neutral lipids predict progression from mild cognitive impairment to Alzheimer’s disease
    Farida Dakterzada, Mariona Jové, Raquel P Huerto, Anna Carnes, Joaquím Sol, Reinald Pamplona, Gerard Piñol‐Ripoll · 2023 · GeroScience
  34. The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling
    Christopher Lee, Stephanie Michelle Willerth, Haakon B. Nygaard · 2020 · Progress in Neurobiology
  35. Spatially resolved mass spectrometry analysis of amyloid plaque‐associated lipids
    Martina Blank, Carsten Hopf · 2020 · Journal of Neurochemistry
  36. Screening Platforms for Genetic Epilepsies—Zebrafish, iPSC-Derived Neurons, and Organoids
    Aleksandr Shcheglovitov, Randall Theodore Peterson · 2021 · Neurotherapeutics
  37. Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons
    Rodrigo S. Chaves, My Tran, Andrew R. Holder, Alexandra M. Balcer, Andrea M. Dickey, Elizabeth A. Roberts, Brian G. Bober, Edgar Gutierrez, Brian Patrick Head, Alex Groisman et al. · 2021 · Journal of Neuroscience
  38. Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer’s disease
    Sailee S. Lavekar, Jade Harkin, Melody Hernandez, Cátia Gomes, Shruti Patil, Kang-Chieh Huang, Shweta S. Puntambekar, Bruce T. Lamb, Jason S. Meyer · 2023 · Scientific Reports
  39. Insulin Resistance Is a Modifying Factor for Parkinson's Disease
    Alise Žagare, Ahmed Abdelmonem Hemedan, Catarina Serra-Almeida, Daniela Frangenberg, Gemma Gomez‐Giro, Paul M. A. Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Marek Ostaszewski et al. · 2024 · Movement Disorders
  40. Regulation of Small GTPase Prenylation in the Nervous System
    Reddy, Jairus M., Raut, Namrata G. R., Seifert, Jennifer L., Hynds, DiAnna L. · 2020 · Molecular Neurobiology
  41. Association of fish oil supplementation with risk of incident dementia: A prospective study of 215,083 older adults
    Xiaohui Liu, Pan Zhuang, Yin Li, Fei Ling Wu, Xuzhi Wan, Yu Zhang, Jingjing Jiao · 2022 · Clinical Nutrition
  42. Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases
    Na Zhan, Boyang Wang, Nikita Martens, Yankai Liu, Shangge Zhao, Gardi J. Voortman, Jeroen van Rooij, Frank P. J. Leijten, Tim Vanmierlo, Folkert Kuipers et al. · 2023 · International Journal of Molecular Sciences
  43. Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease
    Farida Dakterzada, Mariona Jové, Raquel P Huerto, Anna Carnes, Joaquím Sol, Reinald Pamplona, Gerard Piñol‐Ripoll · 2023 · Aging and Disease
  44. Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation
    Valencia-Olvera, Ana C., Balu, Deebika, Faulk, Naomi, Amiridis, Aspasia, Wang, Yueting, Pham, Christine, Avila-Munoz, Eva, York, Jason M., Thatcher, Gregory R.J., LaDu, Mary Jo · 2023 · Neurotherapeutics
  45. The Advancements of Marine Natural Products in the Treatment of Alzheimer’s Disease: A Study Based on Cell and Animal Experiments
    Chunbo Jia, Jiaxin Chai, Shenyun Zhang, Yining Sun, Liheng He, Zhipei Sang, Dapeng Chen, Xu Zheng · 2025 · Marine Drugs
  46. Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems
    Kristina Rehbach, Michael B. Fernando, Kristen Brennand · 2020 · Journal of Neuroscience
  47. Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics
    Pingyuan Ge, Yiyu Qi, Shu‐Yue Qu, Xin Zhao, Sai‐jia Ni, Zeng‐Ying Yao, Rui Hong Guo, Nian‐Yun Yang, Qichun Zhang, Hua‐Xu Zhu · 2021 · Drug Design Development and Therapy
  48. ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia
    Haibo Li, Thao Nguyen Thanh Huynh, Michael Tran Duong, James G. Gow, Catherine C.Y. Chang, Ta‐Yuan Chang · 2023 · International Journal of Molecular Sciences
  49. Enhancing α-secretase Processing for Alzheimer’s Disease—A View on SFRP1
    Bor Luen Tang · 2020 · Brain Sciences
  50. The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
    Femke M. Feringa, Sascha Koppes-den Hertog, Lian Y. Wang, Rico J. E. Derks, Iris Daphne Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
    Zheping Chen, Shenghan Wang, Zhaoqian Meng, Yuyang Ye, Guoliang Shan, Xinyue Wang, Xin Zhao, Yanwu Jin · 2023 · Frontiers in Neuroscience
  52. Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model
    Kamran Muddasar Saeed, Shahid Ali Shah, Rahat Ullah, Sayed Ibrar Alam, Jun Sung Park, Samreen Saleem, Myeung Hoon Jo, Min Woo Kim, Jong Ryeal Hahm, Myeong Ok Kim · 2020 · Oxidative Medicine and Cellular Longevity · Retracted
  53. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
    Chialin Cheng, Surya A. Reis, Emily T. Adams, Daniel M. Fass, Steven P. Angus, Timothy Joseph Stuhlmiller, Jared I. Richardson, Hailey R. Olafson, Eric T. Wang, Debasis Patnaik et al. · 2021 · Scientific Reports
  54. Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets
    Wang, Ning-Qi, Sun, Pei-Xiang, Shen, Qi-Qi, Deng, Meng-Yan · 2025 · Molecular Neurobiology
  55. Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
    Ye Tao, Yangyang Duan, Hayley W. S. Tsang, He Jax Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K.Y. Fu, Nancy Y. Ip · 2021 · Communications Biology
  56. Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases
    Irina A. Pikuleva · 2021 · Exploration of Neuroprotective Therapy
  57. Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model
    Swati Mishra, Chizuru Kinoshita, Alison D. Axtman, Jessica E. Young · 2022 · Frontiers in Molecular Neuroscience
  58. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer’s disease vulnerable neurons
    Patricia Rodriguez‐Rodriguez, Luis Enrique Arroyo‐García, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Ángel Cedazo-Mı́nguez, Subhash C. Sinha et al. · 2024 · Brain
  59. Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer’s Disease
    Eleonora Cipollari, Hannah J. Szapary, Antonino Picataggi, Jeffrey T. Billheimer, Catherine A. Lyssenko, Gui‐Shuang Ying, Leslie M. J. Shaw, Mitchel A. Kling, Rima Kaddurah‐Daouk, Daniel James Rader et al. · 2020 · Journal of Alzheimer s Disease
  60. Expression of tiRNA and tRF in APP/PS1 transgenic mice and the change of related proteins expression
    Honglin Lu, Lin Liu, Shu Han, Binbin Wang, Jin Qin, Kailin Bu, Yingzhen N. Zhang, Zhongzhong Li, Lina Ma, Jing Tian et al. · 2021 · Annals of Translational Medicine
  61. PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy
    Keiko Morita, Mariko Wada, Kohta Nakatani, Yuki Matsumoto, Nahoki Hayashi, Ikuko Yamahata, Kotone Mitsunari, Nagi Mukae, Masatomo Takahashi, Yoshihiro Izumi et al. · 2022 · iScience
  62. TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids
    Gabriela Goldberg, Luisa Bulcao Vieira Coelho, Guoya Mo, Laura Ann Adang, Meenakshi Patne, Zhoutao Chen, Ivan García-Bassets, Pinar Mesci, Alysson Renato Muotri · 2023 · Molecular Psychiatry
  63. Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo
    Zhuojun Liu, Jia Liu, Tianming Zhang, Mingxia Shi, Xiaofang Chen, Yun Chen, Jian Yu · 2019 · Pharmacological Research
  64. Alzheimer’s disease basics: we all should know
    S.K. Das · 2025 · Neurological Research
  65. APOE4-driven lipid metabolic dysregulation in Alzheimer's disease: Multi-pathway mechanisms and therapeutic perspectives
    Wen-Xuan Zhang, Yi-Liang Yang, Jiaxin Yu, Lihong Jia, Han‐Chang Huang · 2025 · Biochemical and Biophysical Research Communications
  66. Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains
    Eugen Semikasev, Barbara Ahlemeyer, Till Acker, Anne Schänzer, Eveline Baumgart‐Vogt · 2023 · Acta Neuropathologica Communications
  67. APOE ε4 allele, along with G206D-PSEN1 mutation, alters mitochondrial networks and their degradation in Alzheimer’s disease
    Irene Costa Laparra, Elena Juárez‐Escoto, Carlos Vicario‐Abejón, Rosario Moratalla, Patricia García‐Sanz · 2023 · Frontiers in Aging Neuroscience
  68. Unlocking the therapeutic potential: odyssey of induced pluripotent stem cells in precision cell therapies
    Popat B Mohite, Abhijeet Vishnu Puri, Roshan Dave, Aarati Budar, Shubham V. Munde, Shruti Bagchi Ghosh, Taha Alqahtani, Humood Al Shmrany, Ajoy Kumer, Bikram Dhara · 2024 · International Journal of Surgery
  69. New treatment modalities in Alzheimer's disease
    Emel Köseoğlu · 2019 · World Journal of Clinical Cases
  70. LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project
    Francisca A. de Leeuw, Betty Marije Tijms, Astrid S. Doorduijn, Heleen M. A. Hendriksen, Ondine van de Rest, Marian A.E. de van der Schueren, Marjolein Visser, Ellen G. H. M. van den Heuvel, Nick van Wijk, Jörgen Bierau et al. · 2020 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
  71. Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia
    Jun Yup Lee, Oana C. Marian, Anthony Simon Don · 2021 · NeuroMolecular Medicine
  72. Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
    Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang · 2025 · Small Science
  73. Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
    Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L. Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo et al. · 2025 · Journal of Internal Medicine
  74. Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
    Xueyan Huang, Lu‐Lu Xue, Ting‐Bao Chen, Li‐Ren Huangfu, Ting‐Hua Wang, Liu‐Lin Xiong, Changyin Yu · 2023 · Frontiers in Pharmacology
  75. The Cross-Talk Between the Peripheral and Brain Cholesterol Metabolisms
    Ilinca Săvulescu-Fiedler, Luiza-Roxana Dorobantu-Lungu, Şerban Dragosloveanu, Serban Nicolae Benea, Christiana Diana Maria Dragosloveanu, Ana Căruntu, Andreea-Elena Scheau, Constantin Căruntu, Cristian Scheau · 2025 · Current Issues in Molecular Biology
  76. Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer’s disease
    Thaddeus K. Weigel, Joshua A. Kulas, Heather Anne Ferris · 2019 · Neuronal Signaling
  77. Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer’s disease
    Shan Zhong, Mengdi Wang, Yaxi Zhan, Jie Zhang, Xiaoli Yang, Shumei Fu, Danlei Bi, Feng Gao, Yong Shen, Zuolong Chen · 2020 · Bioscience Biotechnology and Biochemistry
  78. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease
    Andrew B. Caldwell, Qing Liu, Can Martin Zhang, Gary P. Schroth, Douglas R Galasko, Kevin D. Rynearson, Rudolph E. Tanzi, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam · 2022 · Alzheimer s & Dementia
  79. Does statin use affect amyloid beta deposition and brain metabolism?
    Fardin Nabizadeh, Parya Valizadeh, Mohammad Balabandian, Alzheimer’s Disease Neuroimaging Initiative · 2023 · CNS Neuroscience & Therapeutics
  80. RETRACTED: The Intersection of cerebral cholesterol metabolism and Alzheimer's disease: Mechanisms and therapeutic prospects
    Licheng Liu, Junyi Liang, Yan-hong Liu, Bin Liu, Xiaohong Dong, Wen-hui Cai, Ning Zhang · 2024 · Heliyon · Retracted
  81. Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies
    Tsumagari, Kazuya, Sato, Yoshiaki, Shimozawa, Aki, Aoyagi, Hirofumi, Okano, Hideyuki, Kuromitsu, Junro · 2022 · iScience
  82. Dietary Lipid Intervention in the Prevention of Brain Aging
    Wei Xiong, Bing Fang, Xiaoyu Wang, Ming Zhang, Min Du, Jiazeng Sun, Juan Chen, Yixuan Li, Changhao Sun, Xin Gen Lei et al. · 2023 · Engineering
  83. Mechanisms of 3-Hydroxyl 3-Methylglutaryl CoA Reductase in Alzheimer’s Disease
    Xun Zhou, Xiaolang Wu, Rui Wang, Lu Han, Hui-Lin Li, Wei Zhao · 2023 · International Journal of Molecular Sciences
  84. Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer’s Disease in the APPswePS1ΔE9 Mouse Model
    Nikita Martens, Na Zhan, Sammie C. Yam, Frank P. J. Leijten, Marcella Palumbo, Martien P. M. Caspers, Assia Tiane, Silvia Friedrichs, Yanlin Li, Leonie van Vark‐van der Zee et al. · 2024 · Nutrients
  85. Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson’s disease pathology
    Alise Žagare, Jānis Kurlovičs, Catarina Serra-Almeida, Daniele Ferrante, Daniela Frangenberg, Armelle Vitali, Gemma Gomez‐Giro, Christian Jäger, Paul M. A. Antony, Rashi Halder et al. · 2025 · Journal of Tissue Engineering
  86. Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer’s Disease
    Joel Blanchard, Li‐Huei Tsai · 2019 · Cell stem cell
  87. Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism
    Esteban Gutierrez, Dieter Lütjohann, Anja Kerksiek, Marietta Fabiano, Naoto Oikawa, Lars Kuerschner, Christoph Thiele, Jochen Walter · 2020 · Life Science Alliance
  88. LAMP2 deficiency attenuates the neurodegeneration markers induced by HSV-1 infection
    Henrike Kristen, Isabel Sastre, Sara Aljama, Maria Fuentes, Marı́a Recuero, Ana Frank, Ángel García Martín, Pascual Sánchez‐Juan, Carmen Lage, Maria Jesus Bullido et al. · 2021 · Neurochemistry International
  89. Therapeutic strategies for tauopathies and drug repurposing as a potential approach
    Majedul Islam, Fengyun Shen, Deepika Regmi, Deguo Du · 2022 · Biochemical Pharmacology
  90. Reexamining the Causes and Effects of Cholesterol Deposition in the Brains of Patients with Alzheimer’s Disease
    Zelin Hu, Yang-Qi Yuan, Zhen Tong, Meiqing Liao, Shunling Yuan, Ye Jian, Jia-Lun Yang, Wenfeng Liu · 2023 · Molecular Neurobiology
  91. Towards a Unitary Hypothesis of Alzheimer’s Disease Pathogenesis
    Estela Área-Gómez, Eric A. Schon · 2024 · Journal of Alzheimer s Disease
  92. Progesterone Suppresses Cholesterol Esterification in APP/PS1 mice and a cell model of Alzheimer’s Disease
    Wenjing Shi, Hang Wu, Sha Liu, Zhigang Wu, Honghai Wu, Jianfang Liu, Hou Yan-ning · 2021 · Brain Research Bulletin
  93. Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration
    Noa Roitenberg, Ehud Cohen · 2019 · Trends in Cell Biology
  94. Targeting lipid metabolism in neurodegenerative diseases: From experimental to clinical
    Junpeng Long, Shasha Liu, Yaning Shi, Chanjuan Zhang, Qin Li, Qidi Ai · 2025 · Metabolism
  95. An evidence-based review of neuronal cholesterol role in dementia and statins as a pharmacotherapy in reducing risk of dementia
    Siddhartha Dutta, Sayeeda Rahman, Rahnuma Ahmad, Tarun Kumar, Gitashree Dutta, Sudeshna Banerjee, Abdullahi Rabiu Abubakar, Adekunle Babajide Rowaiye, Sameer Dhingra, V. Ravichandiran et al. · 2021 · Expert Review of Neurotherapeutics
  96. Advancing combination treatment with cilostazol and caffeine for Alzheimer's disease in high fat-high fructose-STZ induced model of amnesia
    Adel A. Gomaa, Hanan S.M. Farghaly, Asmaa Mahmoud Ahmed, Mohamed A. El‐Mokhtar, Fahmy K. Hemida · 2022 · European Journal of Pharmacology
  97. Identifying the earliest-occurring clinically targetable precursors of late-onset Alzheimer's disease
    Bruce M. Cohen, Kai‐Christian Sonntag · 2024 · EBioMedicine
  98. High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly
    Martin H. Berryer, Gizem Rizki, Anna J. Nathanson, Jenny A. Klein, Darina Trendafilova, Sara G. Susco, Daisy Lam, Angelica Messana, Kristina M. Holton, Kyle W. Karhohs et al. · 2023 · eLife
  99. Contribution of Human Pluripotent Stem Cell-Based Models to Drug Discovery for Neurological Disorders
    Alexandra Benchoua, Marie Lasbareilles, Johana Tournois · 2021 · Cells
  100. Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
    John Yong, Jacqueline E. Villalta, Ngoc Vu, Matthew A. Kukurugya, Niclas Olsson, Magdalena Preciado López, Julia R. Lazzari-Dean, Kayley Hake, Fiona Elizabeth McAllister, Bryson D. Bennett et al. · 2023 · eLife