The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Open accessAbstract
Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest. These findings reveal how the outer root sheath (ORS) and inner hair follicle layers coordinate hair production. We found that the ORS is composed of two intermingling but transcriptionally distinct cell types with differing capacities for interactions with stromal cell types. Inner layer cells branch from transcriptionally uncommitted progenitors, and each lineage differentiation passes through an intermediate state. We also provide an online tool to explore this comprehensive skin cell atlas, including epithelial and stromal cells such as fibroblasts, vascular, and immune cells, to spur further discoveries in skin biology.
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Fiji: an open-source platform for biological-image analysis
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Integrating single-cell transcriptomic data across different conditions, technologies, and species
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SCANPY: large-scale single-cell gene expression data analysis
Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881
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ImageJ2: ImageJ for the next generation of scientific image data
Rueden, C. T., Schindelin, J., Hiner, M. C., DeZonia, B. E., Walter, A. E., Arena, E. T., & Eliceiri, K. W. (2017) · BMC Bioinformatics · doi:10.1186/s12859-017-1934-z · Cited by 5,980
Reversed graph embedding resolves complex single-cell trajectories
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Generalizing RNA velocity to transient cell states through dynamical modeling
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Scrublet: computational identification of cell doublets in single-cell transcriptomic data
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Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
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A prenatal skin atlas reveals immune regulation of human skin morphogenesis
Gopee, N. H., Winheim, E., Olabi, B., Admane, C., Foster, A. R., Huang, N., Botting, R. A., Torabi, F., Sumanaweera, D., Le, A. P., et al. (2024) · Nature · doi:10.1038/s41586-024-08002-x · Cited by 108
Self-citationCockburn, K., Annusver, K., Gonzalez, D. G., Ganesan, S., May, D. P., Mesa, K. R., Kawaguchi, K., Kasper, M., & Greco, V. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-01021-8 · Cited by 84
Self-citationSpatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape
Ren, J., Zhou, H., Zeng, H., Wang, C. K., Huang, J., Qiu, X., Sui, X., Li, Q., Wu, X., Lin, Z., et al. (2023) · Nature Methods · doi:10.1038/s41592-023-01829-8 · Cited by 79
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17
Cavagnero, K. J., Li, F., Dokoshi, T., Nakatsuji, T., O’Neill, A. M., Aguilera, C., Liu, E., Shia, M., Osuoji, O., Hata, T., et al. (2024) · Journal of Experimental Medicine · doi:10.1084/jem.20231425 · Cited by 60
Metadata
- Authors
- Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 26
- Issue
- 3
- Pages
- 441-457.e7
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W3007680205
- Cited by
- 328
- References
- 85
- FWCI
- 42.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M. (2020). The Molecular Anatomy of Mouse Skin during Hair Growth and Rest. Cell Stem Cell. https://doi.org/10.1016/j.stem.2020.01.012
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