The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Naive stem cell blastocyst model captures human embryo lineage segregation
Open accessAbstract
Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and hypoblast. Here we describe a human embryo model (blastoid) generated by self-organization. Brief induction of trophectoderm leads to formation of blastocyst-like structures within 3 days. Blastoids are composed of three tissue layers displaying exclusive lineage markers, mimicking the natural blastocyst. Single-cell transcriptome analyses confirm segregation of trophectoderm, hypoblast, and epiblast with high fidelity to the human embryo. This versatile and scalable system provides a robust experimental model for human embryo research.
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Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358 · cited 1×
“We performed single-cell transcriptome analysis, using SMART-seq2 (Picelli et al., 2013) to achieve suitable sequencing depth and facilitate reliable comparison with human embryo scRNA-seq data.”
MethodSingle-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos, S., Edsgärd, D., Reinius, B., Deng, Q., Panula, S. P., Codeluppi, S., Plaza Reyes, A., Linnarsson, S., Sandberg, R., & Lanner, F. (2016) · Cell · doi:10.1016/j.cell.2016.03.023 · Cited by 1,063
Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human
Takashima, Y., Guo, G., Loos, R., Nichols, J., Ficz, G., Krueger, F., Oxley, D., Santos, F., Clarke, J., Mansfield, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.029 · Cited by 952
Self-citationSelf-organization of the human embryo in the absence of maternal tissues
Shahbazi, M. N., Jedrusik, A., Vuoristo, S., Recher, G., Hupalowska, A., Bolton, V., Fogarty, N. M. E., Campbell, A., Devito, L. G., Ilic, D., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3347 · Cited by 688
Self-organization of the in vitro attached human embryo
Deglincerti, A., Croft, G. F., Pietila, L. N., Zernicka-Goetz, M., Siggia, E. D., & Brivanlou, A. H. (2016) · Nature · doi:10.1038/nature17948 · Cited by 680
Blastocyst-like structures generated solely from stem cells
Rivron, N. C., Frias-Aldeguer, J., Vrij, E. J., Boisset, J.-C., Korving, J., Vivié, J., Truckenmüller, R. K., van Oudenaarden, A., van Blitterswijk, C. A., & Geijsen, N. (2018) · Nature · doi:10.1038/s41586-018-0051-0 · Cited by 530
Cited by
Human blastoids model blastocyst development and implantation
Kagawa, H., Javali, A., Khoei, H. H., Sommer, T. M., Sestini, G., Novatchkova, M., Scholte op Reimer, Y., Castel, G., Bruneau, A., Maenhoudt, N., et al. (2022) · Nature · doi:10.1038/s41586-021-04267-8 · Cited by 498
Metadata
- Authors
- Yanagida, A., Spindlow, D., Nichols, J., Dattani, A., Smith, A., & Guo, G.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 28
- Issue
- 6
- Pages
- 1016-1022.e4
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W3158062319
- Cited by
- 320
- References
- 34
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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