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Self-organization of the human embryo in the absence of maternal tissues
Open accessAbstract
Remodelling of the human embryo at implantation is indispensable for successful pregnancy. Yet it has remained mysterious because of the experimental hurdles that beset the study of this developmental phase. Here, we establish an in vitro system to culture human embryos through implantation stages in the absence of maternal tissues and reveal the key events of early human morphogenesis. These include segregation of the pluripotent embryonic and extra-embryonic lineages, and morphogenetic rearrangements leading to generation of a bilaminar disc, formation of a pro-amniotic cavity within the embryonic lineage, appearance of the prospective yolk sac, and trophoblast differentiation. Using human embryos and human pluripotent stem cells, we show that the reorganization of the embryonic lineage is mediated by cellular polarization leading to cavity formation. Together, our results indicate that the critical remodelling events at this stage of human development are embryo-autonomous, highlighting the remarkable and unanticipated self-organizing properties of human embryos.
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Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
Three-dimensional culture models of normal and malignant breast epithelial cells
Lee, G. Y., Kenny, P. A., Lee, E. H., & Bissell, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1015 · Cited by 1,336
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Bredenoord, A. L., Clevers, H., & Knoblich, J. A. (2017) · Science · doi:10.1126/science.aaf9414 · Cited by 334
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Birch, J. (2024) · doi:10.1093/9780191966729.001.0001 · Cited by 236
Messmer, T., von Meyenn, F., Savino, A., Santos, F., Mohammed, H., Lun, A. T. L., Marioni, J. C., & Reik, W. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.099 · Cited by 156
Animal models of human pregnancy and placentation: alternatives to the mouse
Carter, A. M. (2020) · Reproduction · doi:10.1530/rep-20-0354 · Cited by 130
Metadata
- Authors
- Shahbazi, M. N., Jedrusik, A., Vuoristo, S., Recher, G., Hupalowska, A., Bolton, V., Fogarty, N. M. E., Campbell, A., Devito, L. G., Ilic, D., Khalaf, Y., Niakan, K. K., Fishel, S., & Zernicka-Goetz, M.
- Venue
- Nature Cell Biology
- Published
- 2016-05-04
- Volume
- 18
- Issue
- 6
- Pages
- 700-708
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2337398632
- Cited by
- 688
- References
- 2
- FWCI
- 32.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Shahbazi, M. N., Jedrusik, A., Vuoristo, S., Recher, G., Hupalowska, A., Bolton, V., Fogarty, N. M. E., Campbell, A., Devito, L. G., Ilic, D., Khalaf, Y., Niakan, K. K., Fishel, S., & Zernicka-Goetz, M. (2016). Self-organization of the human embryo in the absence of maternal tissues. Nature Cell Biology. https://doi.org/10.1038/ncb3347
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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