Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Victor, Matheus B., Leary, Noelle, Luna, Xochitl, Meharena, Hiruy S., Scannail, Aine Ni, Bozzelli, P. Lorenzo, Samaan, George, Murdock, Mitchell H. +8 more·2022·Cell Stem Cell

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  12. Beyond plaques and tangles: The role of immune cell dysfunction in Alzheimer's disease
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  13. Editorial: Molecular Role of Lipids in Aging
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  14. Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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  15. Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles
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  16. Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion
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  26. RBFOX1 Dysfunction Unlocks APOE4 ‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids
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  28. Outer Membrane Vesicles as Systems-Level Drivers of Neuroinflammation, Metabolic Dysfunction, and Proteinopathy in Alzheimer’s Disease
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  29. Cell-type-specific APOE4 cascade across the Alzheimer’s disease continuum
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  30. Modeling stimulus-induced stress responses in microglia-like cells using a commercial iPSC-dCas9-KRAB line
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  36. Neurons run on fat
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  40. Therapeutic Strategies in Neurodegenerative Diseases
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  42. Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model
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  43. APOE4 alters the lipid droplet proteome and modulates droplet dynamics
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  44. In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands
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  46. Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer’s disease
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  47. ApoE-Dependent Lipid Handling by Median Eminence Microglia Preserves Myelin Integrity and Metabolic Function
    E. McGrath, A. Folick, LJ Morrissette, SM Brown Mayfield, V. Pham, SN Pillutla, Matthew Choi, RT Cheang, W. Bolus, A. Schwendeman et al. · 2026 · bioRxiv
  48. Complement 3a Receptor mediates high fat diet induced hypothalamic accumulation of lipid associated microglia to regulate neuroinflammation and obesity
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  50. Use of Antibiotics and Cognitive Function in Older US Adults
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  55. Neuroprotective Mechanisms and Metabolomics Analysis of Jiedu Yizhi Formula in Alzheimer's Disease
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  56. Fokker-Planck diffusion maps of multiple single cell microglial transcriptomes reveals radial differentiation into substates associated with Alzheimer’s pathology
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  57. Age-related energetic reprogramming in glial cells: possible correlations with Parkinson’s disease
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  58. An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience
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  59. Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro
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  73. Additional file 10 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Yang, Wanjie, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  74. Additional file 2 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  75. Additional file 7 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  76. Additional file 4 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  77. Additional file 3 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  78. Additional file 2 of Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease
    Piaopiao Lian, Cai, Xing, Wang, Cailin, Liu, Ke, Yang, Xiaoman, Yi Wu, Zhang, Zhaoyuan, Zhuoran Ma, Cao, Xuebing, Xu, Yan · 2024 · Figshare
  79. Additional file 1 of Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease
    Piaopiao Lian, Cai, Xing, Wang, Cailin, Liu, Ke, Yang, Xiaoman, Yi Wu, Zhang, Zhaoyuan, Ma, Zhuoran, Cao, Xuebing, Xu, Yan · 2024 · Figshare
  80. Additional file 6 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Yang, Wanjie, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  81. Additional file 3 of Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease
    Piaopiao Lian, Cai, Xing, Wang, Cailin, Liu, Ke, Yang, Xiaoman, Yi Wu, Zhaoyuan Zhang, Zhuoran Ma, Cao, Xuebing, Xu, Yan · 2024 · Figshare
  82. Additional file 11 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Zhang, Y. Jessie · 2024 · Figshare
  83. Additional file 12 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  84. Additional file 9 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  85. Additional file 5 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  86. Additional file 8 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Yang, Wanjie, Siegel, Dionicio, Yan Zhang · 2024 · Figshare
  87. Additional file 1 of Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
    Svetlana Panina, Joshua V. Schweer, Zhang, Qian, Gaurav Raina, Haley A. Hardtke, Kim, Seungjin, Wanjie Yang, Siegel, Dionicio, Zhang, Y. Jessie · 2024 · Figshare
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