Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Victor, Matheus B., Leary, Noelle, Luna, Xochitl, Meharena, Hiruy S., Scannail, Aine Ni, Bozzelli, P. Lorenzo, Samaan, George, Murdock, Mitchell H., von Maydell, Djuna, Effenberger, Audrey H., Cerit, Oyku, Wen, Hsin-Lan, Liu, Liwang, Welch, Gwyneth, Bonner, Maeve, Tsai, Li-Huei·2022·Cell Stem Cell

DOI 10.1016/j.stem.2022.07.005

Cited by (328)

Items 101–200 of 328

APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini, George William Rebeck · 2024 · Molecular Neurodegeneration
Microglial purinergic signaling in Alzheimer’s disease
Shu-Ya Mei, Ning Zhang, Mengjing Wang, Pei-ran Lv, Qi Liu · 2024 · Purinergic Signalling
HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV
Cheng, Yan, Jung, Jaekeun, Guo, Liyang, Shuboni-Mulligan, Dorela D., Chen, Jian-Fu, Hu, Wenhui, Guo, Ming-Lei · 2025 · Brain, Behavior, and Immunity
Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
Xiaojie Zhao, Yan Li, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Alena Kozlova, Matthew J. Moulton, Lindsey D. Goodman, Zhiping P. Pang, Alan R. Sanders et al. · 2025 · Molecular Neurodegeneration
Fatty acid-binding protein 4 drives microglia-mediated neuroinflammation through promoting S100A9 expression and lipid droplet accumulation after intracerebral hemorrhage
Jiaqing He, Zijuan Qin, Haixiao Liu, Yaning Cai, Hao Wu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu et al. · 2025 · Journal of Neuroinflammation
APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer’s Disease and Cardiovascular Disease
Чан Лю, Juan Liu, Yanyang Wang, Shang-Fu Xu, Li-Mei Yu · 2025 · Molecular Neurobiology
Cure of Alzheimer’s Dementia Requires Addressing All of the Affected Brain Cell Types
Jeffrey Fessel · 2023 · Journal of Clinical Medicine
The role of microglia in neurodegenerative diseases
Da-Ao Nie, Jiangkun Yu, Wenshan Huang, Guihua Li, Xuying He, Jie-Hua Xu · 2025 · Molecular Immunology
Mechanisms of high-density lipoprotein in regulating blood-brain barrier function: insights and implications
Pengxi Zhu, Liyao Xiao, Yijie Wang · 2025 · Fluids and Barriers of the CNS
APOE-Targeted Therapeutics for Alzheimer's Disease
Hussein N. Yassine, Cristelle Hugo, Bernadette O’Donovan, Isaiah O. Stephens, Lance A. Johnson, Gregory M. Cole, Julia TCW, Jan O. Johansson, Kassandra Kisler, Ornit Chiba‐Falek · 2025 · Journal of Neuroscience
Alzheimer’s Disease and Impaired Bone Microarchitecture, Regeneration and Potential Genetic Links
Min Zhang, Shunze Hu, Xuying Sun · 2023 · Life
Removing non-resonant background of CARS signal with generative adversarial network
Ziyi Luo, Xiangcong Xu, Danying Lin, Junle Qu, Fangrui Lin, Jia Li · 2024 · Applied Physics Letters
Sleep quality, APOE ε4, and Alzheimer’s disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis
Lin Huang, Lan Tan, Chen‐Chen Tan, Xinyu Zhang, Lin Xu, Juanjuan Zou, Yu-Jing Lin, Yuying Zhang, Quan Hao, Zi-Qi Zhang et al. · 2025 · BMC Medicine
ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease
Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze · 2025 · The Journal of Experimental Medicine
Microglia in systemic neuroimmune communication: functions beyond phagocytosis
Di Pietro, Anabella Ayelen, Powley, Sharon, Perciballi, Elisa, Stewart, Meredith, Therrien, Martine, Scott-Hewitt, Nicole · 2026 · Trends in Immunology
Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
Kristen M. Pitts, Milica A. Margeta · 2023 · Frontiers in Cellular Neuroscience
Lipid-Laden Microglia: Characterization and Roles in Diseases
Jiani Xing, Takese McKenzie, Jian Hu · 2025 · Cells
Lipid droplet dynamics in type 2 diabetes and its complications: pathophysiological insights and therapeutic options
Caiyi Long, Zihan Li, Liangliang Jiang, Xinyu Yang, Siyu Deng, Yayi Jiang, Boxun Zhang, Rensong Yue · 2025 · Lipids in Health and Disease
Targeting lipid metabolism in neurodegenerative diseases: From experimental to clinical
Junpeng Long, Shasha Liu, Yaning Shi, Chanjuan Zhang, Qin Li, Qidi Ai · 2025 · Metabolism
Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease
Maria Kokkali, Kanelina Karali, Evangelia Thanou, Μαρία Παπαδοπούλου, Ioanna Zota, Alexandros Tsimpolis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Ka Wan Li, Kyriaki Sidiropoulou et al. · 2024 · Molecular Psychiatry
Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease
Huicong Liu, Shuo Wen, Chang Jie Xu, Xiaohong Kang, Eryan Kong · 2025 · Journal of Lipid Research
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
Zhu, Keying, Liu, Yun, Min, Jin-Hong, Joshua, Vijay, Lin, Jianing, Li, Yue, Kreutzmann, Judith C., Guo, Yuxi, Xia, Wenlong, Mohammadi, Elyas et al. · 2026 · Nature Neuroscience
Multisite chronic pain: association with cognitive decline and post-mortem Alzheimer’s biomarkers
Tyler Reed Bell, Carol E. Franz, Imanuel R. Lerman, McKenna E. Williams, Christine Fennema‐Notestine, Matthew S. Panizzon, Jeremy A. Elman, David Alan Bennett, William S. Kremen · 2025 · Brain Communications
Dynamic Intercellular Networks in the CNS: Mechanisms of Crosstalk from Homeostasis to Neurodegeneration
Yutian Zheng, Rui Huang, Jie Pan · 2025 · International Journal of Molecular Sciences
Microglia–Neuron Crosstalk: An Intimate Molecular Conversation in Neurodegeneration
Shiqi Wang, Sichen Wang, Hongzhuan CHEN, Jianrong Xu · 2026 · International Journal of Molecular Sciences
Mitochondria-related HSDL2 is a potential biomarker in temporal lobe epilepsy by modulating astrocytic lipid metabolism
Xiaxin Yang, Jianhang Zhang, Zhihao Wang, Zhong Yao, Xue Yao Yang, Xingbang Wang, Xiuhe Zhao, Shuo Xu · 2024 · Neurotherapeutics
Withaferin a modulation of microglia autophagy mitigates neuroinflammation and enhances cognitive function in POCD
Haijun Hu, Bingbing Cao, Dan Ai Huang, Yue Lin, Bin Zhou, Binwu Ying, Lelin Huang, Lieliang Zhang · 2024 · Scientific Reports
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Diana Acosta Ingram, E. Turkes, Tae Yeon Kim, Sheeny V. Vo, Nicholas Sweeney, M. Bonte, R. Rutherford, Dominic L. Julian, Mei-Xia Pan, Jacob A. Marsh et al. · 2025 · Nature Communications
APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae
Chen, Junru, Chen, Haibing, Wei, Qinjun, Lu, Yajie, Wang, Tianming, Pang, Xiuhong, Xing, Guangqian, Chen, Zhibin, Cao, Xin, Yao, Jun · 2025 · Cell Death Discovery
ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition
Erika Di Biase, Kyle J. Connolly, Ingrid S. Crumpton, Oliver Cooper, Penelope J. Hallett, Ole Isacson A · 2025 · Scientific Reports
Innovations advancing our understanding of microglia in Alzheimer's disease: From in vitro to in vivo models
Simon Maksour, Lezanne Ooi · 2023 · Journal of Neurochemistry
Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer’s disease
Hao Huang, Rong Xiang, Riqiang Yan · 2024 · Translational Neurodegeneration
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons
Young, Jessica E., Jayadev, Suman · 2022 · Cell Stem Cell
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease
Tanya N. Weerakkody, Hanna Sabelström, Shan V. Andrews, Jean Paul Chadarevian, Marcus Y. Chin, David Tatarakis, Nicholas E. Propson, Do Jin Kim, Richard Theolis, Gian Carlo G. Parico et al. · 2025 · Science Translational Medicine
Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yu‐Fan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang et al. · 2025 · Advanced Science
Sense to Tune: Engaging Microglia with Dynamic Neuronal Activity
Kelei Cao, Yaling Hu, Zhihua Gao · 2022 · Neuroscience Bulletin
ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain
Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology
Yuchen Zhang, Shibo Zhang, Xuyu Zhao, Peiru Wu, Yiwei Ying, Lingling Wu, Junyi Zhuang, Zixin Chen, Yufan Chao, Xin Dong et al. · 2025 · MedComm
Parabiosis, Assembloids, Organoids (PAO)
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang · 2025 · Advanced Science
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis
Ling-Zhi Wu, Jian-Qin Wang, Ya-Wei Wang, Jun-Han Yang, Yuanhang Yao, Yong-Lun Wang, Dong Huang, Yating Hu, Xinxuan Xu, Renqian Wang et al. · 2026 · Nature
Building in vitro models of the brain to understand the role ofAPOEin Alzheimer’s disease
Rebecca L. Pinals, Li‐Huei Tsai · 2022 · Life Science Alliance
Friends and Foes in Alzheimer’s Disease
Ernest K. J. Pauwels, Gerard J. Boer · 2023 · Medical Principles and Practice
Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health
Zihan Li, Jiarui Wu, Tianyuan Zhao, Yiyun Wei, Yajing Xu, Zongjian Liu, Xiaoqiong Li, Xuechai Chen · 2024 · Frontiers in Cellular Neuroscience
The role of TREM2 in myelin sheath dynamics: A comprehensive perspective from physiology to pathology
Xinwei Que, Tongtong Zhang, X Y Liu, Yunsi Yin, Xinyi Xia, Ping Gong, Weiyi Song, Qi Qin, Qing Xu, Yi Tang · 2025 · Progress in Neurobiology
The Role of APOA-I in Alzheimer’s Disease: Bridging Peripheral Tissues and the Central Nervous System
Guanfeng Xie, Gege Jiang, Liqin Huang, Shangqi Sun, Yuwei Wan, Fang Li, Bingjie Wu, Ying Zhang, Xiaoyi Li, Bingwan Xiong et al. · 2025 · Pharmaceuticals
Sterile innate immune mechanisms in neurodegenerative diseases
Alyssa Ealy, Amanda M Serapiglia, Nikhil Panicker · 2025 · Journal of Biological Chemistry
Recent advances in Alzheimer’s disease: From molecular mechanisms to therapeutic strategies
Michelle Diane Rudman, Jason D. Ulrich, David M. Holtzman · 2026 · Cell
This is how an Alzheimer’s gene ravages the brain
Elie Dolgin · 2022 · Nature
CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis
Lingzhi Wu, Jianqin Wang, Yawei Wang, Junhan Yang, Yuanhang Yao, Dong Huang, Yating Hu, Xinxuan Xu, Renqian Wang, Wenjing Du et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Effects of donepezil treatment on plasma and urine metabolites in amyloid beta-induced Alzheimer's disease rats
Hong Huang, Chuanming Fang, Hongxia Niu, Xiangjun Yin, Jiazhao Ruan, Mengying Wei, Yuan Zhou · 2023 · Journal of Chromatography B
PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases
Yiyue Shi, Wenyu Hou, Bei Li, Caihong Zhu · 2025 · Communications Biology
Alzheimer’s risk variant APOE4 linked to myelin-assembly malfunction
Karl E. Carlström, Gonçalo Castelo‐Branco · 2022 · Nature
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains’ Inflammatory Profiles
Thao Nguyen Thanh Huynh, Emma N. Fikse, Adrianna L. De La Torre, Matthew C. Havrda, Catherine C.Y. Chang, Ta‐Yuan Chang · 2024 · International Journal of Molecular Sciences
Alzheimer’s Disease in Diabetic Patients: A Lipidomic Prospect
Bassel Eldeen Makki, Sarah B. Rahman · 2023 · Neuroscience
Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders
Christina Michalski, Zhexing Wen · 2023 · Frontiers in Psychiatry
PILRA regulates microglial neuroinflammation and lipid metabolism as a candidate therapeutic target for Alzheimer’s disease
Kathryn M. Monroe, Tanya N. Weerakkody, Hanna Sabelström, David Tatarakis, Jung H. Suh, Marcus Y. Chin, Shan V. Andrews, Nicholas E. Propson, Srijana Balasundar, Sonnet S. Davis et al. · 2024 · Research Square
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Shaowei Wang, Boyang Li, Zhiheng Cai, Cristelle Hugo, Jie Li, Yi Eve Sun, Qian Lü, Alan Thomas Remaley, Julia TCW, Helena Chang Chui et al. · 2024 · Research Square
APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics
Carla Cuní‐López, Jessica T. Root, Ying Hao, Isabelle Kowal, Niek Blomberg, Rodolfo Ghirlando, Linda G. Yang, Sascha Koppes-den Hertog, Mark Cookson, Rik van der Kant et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro
Anna Podlesny‐Drabiniok, Carmen Romero‐Molina, Tulsi Patel, Wen Yi See, Yiyuan Liu, Edoardo M. Marcora, Alison Goate · 2025 · Cell Reports
Unraveling APOE4: The dual role in CNS and peripheral inflammation in Alzheimer's disease
Xiaohan Li, Zekun Li, Hua Chen, Hongmin Guo, Yihao Ge, Fang Dong, Fan Zhang, Feng Zhang · 2025 · International Immunopharmacology
Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
Ze-Xi Jia, Mengtian Guo, Meimei Li, Pan Liao, Bo Yan, Wei Zhang, Fang-Yuan Cheng, Yaru Liu, Zi-Han Zhang, Cheng Wei et al. · 2025 · Military Medical Research
Transcriptional regulation of disease-relevant microglial activation programs
Amanda McQuade, Reet Mishra, Venus Hagan, Weiwei Liang, Peter J. Colias, Vincent Cele Castillo, Bianca Gonzalez, Justin P. Lubin, Verena Claudia Haage, Victoria S. Marshe et al. · 2026 · Neuron
Dietary modulation of the gut–immune–brain axis: nutritional immunoepigenomics for immune regulation in autoimmunity, cancer, and infection
Dr. Arpita Mukherjee · 2026 · Clinical Immunology Communications
Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis D. Wever, Brechtje de Jong, Marc T.C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick Frans Swaab et al. · 2026 · Alzheimer s & Dementia
Microglia-associated progression of multiple sclerosis: target identification and therapeutic engagement in human in vitro models
Alica Blenkle, Anastasia Geladaris, Martin S. Weber · 2026 · Experimental & Molecular Medicine
Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types
Jeffrey Fessel · 2023 · Discover Mental Health
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
Emmy Li, Camila Benitez, Steven C. Boggess, Mark Koontz, Indigo V.L. Rose, Delsy Martinez, Nina M. Dräger, Olivia M. Teter, Avi J. Samelson, Na’im Pierce et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons
Se-In Lee, Heejin Lim, Na Yeon Kim, J. Jessica Yu, Joonho Cho, Hyein G. Lee, Dae Won Moon, Jinsoo Seo · 2025 · iScience
A single-cell atlas of mouse central nervous system immune cells reveals unique infection-stage immune signatures during the progression of meningitis caused by Streptococcus suis
Xuan Jade Jiang, Jikun Mei, Junhui Zhu, Yanyan Tian, Tong Wu, Ziheng Li, Zengshuai Wu, Tamim Abdelaal, Fengyang Li, Na Li et al. · 2025 · Communications Biology
The Synergistic Role of ApoE4 and GSK3β in Alzheimer’s Disease: Pathological Mechanisms and Therapeutic Implications
Qianwei Li, Yinghui Shang, Han‐Chang Huang, Xueling Dai, Fengxue Lao · 2025 · Molecular Neurobiology
Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4
Nolt, Georgia L., Golden, Lesley R., Thorpe, Shealee P., Funnell, Jessica L., Stephens, Isaiah O., Hernandez, Gabriela, MacLean, Steven M., Lucido, Chloe C., Brock, Chesney R., Pallerla, Akhil V. et al. · 2025 · Journal of Neuroinflammation
Sleep-dependent clearance of brain lipids by peripheral blood cells
Bumsik Cho, Diane E. Youngstrom, Samantha L. Killiany, Camilo Guevara, Caitlin E. Randolph, Connor H. Beveridge, Pooja Saklani, Gaurav Chopra, Amita Sehgal · 2026 · Nature
Cellular mechanisms of brain lipid metabolism in health and disease
Francesco Petrelli, Carlotta Gilardi, Carla Marie Igelbüscher, Diana Panfilova, Alicia Rey, Rosa Chiara Paolicelli, Marlen Knobloch · 2026 · Nature Cell Biology
Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects
Yixuan Du, Chujun Sun, Lingxi Wu, Zhongyun Wu, Yue Tong, Hong Tian, Yang Mao, Xupeiyao Shi, Haohui Ding, Wenbin Xie et al. · 2026 · Cell Metabolism
The Promise of Epigenetic Editing for Treating Brain Disorders
Luis Alfonso González-Molina, Amalia M. Dolga, Marianne G. Rots, Federica Sarno · 2025 · Sub-cellular biochemistry/Subcellular biochemistry
Lipid droplets deposition in perihematoma tissue is associated with neurological dysfunction after intracerebral hemorrhage
Zhangze Wu, Quan Zhao, Ziqi Hu, Dongsheng Jiao · 2025 · Neuroreport
Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids
Verena Schmied, Medina Korkut-Demirbaş, Alessandro Venturino, Juan Pablo Maya-Arteaga, Sandra Siegert · 2025 · Journal of Neuroinflammation
Systems Medicine as a Strategy to Deal with Alzheimer’s Disease
Xiao Xue Zeng, Jie Zeng · 2023 · Journal of Alzheimer s Disease
N -Glycan profile of the cell membrane as a probe for lipopolysaccharide-induced microglial neuroinflammation uncovers the effects of common fatty acid supplementation
Sheryl Joyce B. Grijaldo-Alvarez, Michael Russelle Alvarez, Ryan Lee Schindler, Armin Oloumi, Noah Hernandez, Tristan Seales, Jorge Gil C. Angeles, Ruel C. Nacario, Gladys Cherisse J. Completo, Angela M. Zivkovic et al. · 2024 · Food & Function
The Spectrum of Microglia: Decoding Heterogeneity and Plasticity for Therapeutic Gain in Neurological Disorders
Cheng Gao, Zhehao Lin, Yuxinyue Chen, Rui Gan, Ke Wang, Xiaoyu He, Haijun Han · 2025 · Neuropharmacology and Therapy
Lithium chloride suppresses ferroptosis of induced pluripotent stem cells with ApoE4/E4 from a sporadic Alzheimer's disease patient
Ying Wang, Samuel Anchipolovsky, Piplu Bhuiyan, Luna Sato, Ge Liang, De‐Maw Chuang, Huafeng Wei · 2026 · Neurotherapeutics
Lipid Droplet-Accumulating Microglia as a Therapeutic Node in Neurodegenerative Disease
Siqi Guo, Q Y Zhang, Rui Guo, Liyuan Fu, Huaxu Zhu, Qichun Zhang · 2026 · ACS Chemical Neuroscience
Astrocytic lipid dysregulation as an early driver of neurodegeneration
Woojin Scott Kim, Glenda Margaret Halliday · 2026 · Nature Reviews Neurology
Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Li Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li · 2025 · Advanced Science
Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration
Birkle, Timothy J.Y., Willems, Henriette M.G., Skidmore, John, Brown, Guy C. · 2024 · iScience
Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression‐like behaviors in 5xFAD mice
Yanju Gong, Mingfeng Li, Min Liu, Xinghan Wu, Yanhong Li, Chuan Qin, Ling Zhang · 2024 · Animal Models and Experimental Medicine
Fokker-Planck diffusion maps of microglial transcriptomes reveal radial differentiation into substates associated with Alzheimer’s pathology
Andrew M. Baumgartner, Max Robinson, Nilüfer Ertekin‐Taner, Todd Eliot Golde, Suman Jayadev, Sui Huang, Jennifer Hadlock, Cory C. Funk · 2025 · Communications Biology
Human induced pluripotent stem cell models for Alzheimer’s disease research: a bibliometric analysis
Yuning Sun, Zhilong Liu, Zongbo Zhang, Yufeng Kang, Xinjiang Wang, Yiping Zhang, Yanru Liu, Pei Zhao · 2025 · Frontiers in Human Neuroscience
Metabolic control of microglia in health and disease
Gloria Colombo, Katia Monsorno, Rosa Chiara Paolicelli · 2025 · Handbook of clinical neurology
Spatiotemporal transcriptomic profiling and modeling of mouse brain at single-cell resolution reveals cell proximity effects of aging and rejuvenation
Eric Sun, Olivia Y. Zhou, Max Hauptschein, Nimrod Rappoport, Lucy Xu, Paloma Navarro Negredo, Ling A. Liu, Thomas A. Rando, James Zou, Anne Brunet · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Multiomic Evidence for a Unified Model of Alzheimer’s Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown
Tom Paterson, Jennifer A. Rohrs, Timothy J. Hohman, Mark E. Mapstone, Peter J. Meikle, Rima Kaddurah‐Daouk, Allan I. Levey, Leroy Hood, Alzheimer’s Disease Neuroimaging Initiative, Cory C. Funk · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Fueling Alzheimer’s Disease: Where Does Immunometabolism Stand?
Sónia C. Correia, George L. Perry, Paula Isabel Moreira · 2024 · Journal of Alzheimer s Disease
Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice
Ramkumar Thiyagarajan, Rupadevi Muthaiah, Bhavana Sreevelu, Owen Paul Treanor, Yonas Z. Redae, Reem Nagi Berman, Anna L. Davis, Nanda Kumar Yellapu, Spencer R. Rosario, Lee Daniel Chaves et al. · 2025 · GeroScience
Neuronal alpha-synuclein-mediated autophagy drives lipid droplets accumulation in astrocytes and microglia and aggravates ischemic stroke
Wenqiang Xin, Wei Wei, Xiaoyue Luo, Zhongnan Hao, Lin Zhang, Yan-Mei Zeng, Hao Wan, Shangsong Yang, Xiaobin Shang, Meihua Li et al. · 2025 · International Journal of Biological Macromolecules
Metabolic Reprogramming of Microglia in Neuroinflammation and Depression
Qingru Wu, Jing Tian, Yan Gu, Xiaoying Bi, Hailing Zhang · 2026 · International Journal of Molecular Sciences
Lipid droplets, an enigmatic organelle under the spotlight
Lin Fu, Hongsheng Lu, RC Li, Pingsheng Liu, Bin Liang · 2026 · Protein & Cell
Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals
Ming‐Lei Guo, Yan Cheng, Damian Martinez Pineda, Rachael Elizabeth Dempsey, Lifang Yang · 2024 · Aging and Disease
Large-Scale Population-Based Studies of Blood Metabolome and Brain Health
Zdenka Pausová, Eeva Sliz · 2024 · Current topics in behavioral neurosciences
An optimized method to visualize lipid droplets in brain tissue demonstrates their substantial accumulation in aged brains
Francesco Petrelli, Alicia Rey, Diana Panfilova, Sofia Madsen, Noéline Héritier, Marlen Knobloch · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience
Cinzia Vicidomini, Travis D. Goode, Kathleen M. McAvoy, Ruilin Yu, Conor H. Beveridge, Sanjay N. Iyer, Matheus B. Victor, Noelle Leary, Liam Evans, Michael J. Steinbaugh et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)