Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Victor, Matheus B., Leary, Noelle, Luna, Xochitl, Meharena, Hiruy S., Scannail, Aine Ni, Bozzelli, P. Lorenzo, Samaan, George, Murdock, Mitchell H. +8 more·2022·Cell Stem Cell
DOI 10.1016/j.stem.2022.07.005

Cited by (328)

Items 301–328 of 328

  1. Brain tau network derived biomarker improves the diagnostic accuracy of Alzheimer’s disease
    Tingting Pan, Qi Zhou, Panlong Li, Binbin Nie, Ning Li, Hui Yang, Baoci Shan, Wenliang Li · 2026 · Brain Research Bulletin
  2. APOE4 and INPP5D converge on membrane mechanics to regulate endocytosis in human astrocytes
    Artur S. Gevorgyan, Lila M Gordon, Christian A. Combs, Adrian Lita, Linda G. Yang, Carla Cuní‐López, Jessica T. Root, Mioara Larion, Justin W. Taraska, Priyanka S. Narayan · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation
    G. Rebeck, Giorgi Shautidze, Jordy Sepulveda, Grace Healey, Priyanka S. Narayan · 2026 · Glia
  4. Reshaping the immune landscape: next-generation microglia-targeted therapies for Alzheimer’s disease
    Jianmin Wu, J J Zhao, S Y Chen, Fangyi Xu · 2026 · Biological Research
  5. SPRY1 suppresses microglial fatty acid oxidation by retaining FATP3 on the endoplasmic reticulum in Alzheimer’s disease
    Yu‐Ge Zhang, Shi-Yao Li, Yi-Zhen Hu, Yi Ding, Yu-Tong Zhang, Huiwen Zhang, Y Zhang, Lu Xu, Zhiyuan Zhang, Lei Li · 2026 · Journal of Neuroinflammation
  6. Immunometabolic reprogramming of central and peripheral immune cells in mental disorders: mechanisms and therapeutic implications
    Kexin Lin, Peipei Wang, Shen Li, Chunling Ma, Di Wen, Xia Wang, Linchuan Liao · 2026 · Frontiers in Immunology
  7. Microglial immunometabolism in Alzheimer's disease: A stage-resolved trajectory from adaptive remodeling to the metabolic paradox
    Yue Zou, Yi Ou, Hang Zhao, Ge Chen, Zhong Chen, Yunqin Li, Junliang Jiang · 2026 · Biomedicine & Pharmacotherapy
  8. SIK2-P300 axis Orchestrates the metabolic reprogramming and Immunological functions in microglia of Alzheimer’s disease mice via a dual modulation of lactylation and Acetylation: An epigenetic Perspective
    Xiaoman Dai, Ziling Ye, Xujun Zhang, Yufei Huang, Chen Wang, Yanling Liu, Boya Gao, Jing Zhang, Xiaochun Chen · 2026 · Brain Behavior and Immunity
  9. Multi-omics integration identifies APOE as a metabolic regulator of macrophage-fibroblast crosstalk in idiopathic pulmonary fibrosis
    Bing Bai, Le Chang, Zhi Cheng, Yingjie Wang, Chenfeng Hua, Yonghai Feng, Wenfei Zhao · 2026 · Frontiers in Immunology
  10. Human Stem Cell-Derived Models of the Alzheimer’s Disease Neuroimmune System
    Rose Summers, Daphne Quang, Noah R. Johnson · 2026 · International Journal of Molecular Sciences
  11. Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement
    Nolt, Georgia L., MacLean, Steven M., Golden, Lesley R., Thorpe, Shealee P., Stephens, Isaiah O., Funnell, Jessica L., Brock, Chesney R., Lucido, Chloe C., Smith, Lily, Hernandez, Gabriela et al. · 2027 · Neurobiology of Aging
  12. Human iPSC models reveal APOE4-induced microglial remodeling and extracellular vesicle dysregulation in AD pathogenesis
    Tsuneya Ikezu, Yang You, Son Hoang Nguyen, Sean Mann, Prakruthi Vadakattu, Takahisa Kanekiyo, Zhengrong Zhang, Nibedita Basu Ray, Tony Tuck, Julia TCW et al. · 2026 · Research Square
  13. From physiological homeostasis to pathological injury: Cell-specific functions, imbalance mechanisms, and disease biomarker value of brain lipid droplets
    Qing Zhang, Xiaolin Liu, Le Shi, Yanyu Xu, Xinran Zhang, Jingjing Liu, Qiaoqiao Li, Qinglu Wang, Lijiao Fang · 2026 · International Immunopharmacology
  14. Visualizing Metabolism: Lipid-Based Raman Nanoreporters as an Enabling Platform for Metabolic Imaging and Precision Medicine
    Anu Yadav, Sreejita Pal, Arghyadeep Mayur, Joysmita Dutta, Suresh K. Verma, Manas Ranjan Gartia · 2026 · ACS Nano Medicine
  15. Ultrastructure of Glial Cells in iPSC-Derived Unguided Neural Organoids from APOE4/4 Patients with Alzheimer’s Disease
    Eva Šimončičová, Marloes Verkerke, Fernando Gonzàlez Ibáñez, Raphaël Bourgeois, Katherine Picard, Mohammadparsa Khakpour, Julia TCW, Elly M. Hol, Marie‐Ève Tremblay · 2026 · Neuromethods
  16. Aberrant phase separation from a rare <i>ABI3</i> mutation drives microglial dysfunction and Alzheimer's risk
    Li, Shengnan, Lu, Jiongtong, Zeng, Kaixing, Lu, Xingyu, Zhang, Jiahao, Feng, Sifan, Liang, Chunmei, Cai, Yujie, Yao, Shi, Huang, Qing et al. · 2026 · Alzheimer's &amp; Dementia
  17. Therapeutic Targeting of the LXR Pathway for Improving Myelin Integrity in Neurodegeneration
    Sampada P Tamhankar, Meenakshi Singh, Joyal Xavier, Kristine Griffett, Rajesh Amin · 2026 · Cells
  18. Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
    Eva Šimončičová, Marie‐Ève Tremblay · 2026 · Frontiers in Aging Neuroscience
  19. Remodeling of the brain immune microenvironment in Alzheimer’s disease: interactions among microglia, astrocytes, complement, and the neurovascular unit
    Tong Wang, Lu Wang, Jianing Cao, Yi Zhao, Zongling He, Fengmei Lu · 2026 · Frontiers in Immunology
  20. TDP-43 and ALS - what's wrong with my membranes?
    Regina Dahlhaus, Israfil Yalcin, Julia Tischer, Ralf J. Braun · 2026 · Neurobiology of Disease
  21. miR‐214‐3p and NCKAP1: A microglial functional dimension of Alzheimer's progression
    Min‐Young Noh, 문연실, Sungwoo Kang, Won‐Jin Moon, Hee‐Jin Kim, Sang Won Seo, Sugyeong Ahn, Mi‐Hyeon Kang, Yong Sung Kim, Hyunkee Kim et al. · 2026 · Alzheimer s & Dementia
  22. A lymphotropic biomimetic nanoplatform reverses sleep deprivation-induced cognitive deficits by reprogramming microglial phenotypes
    Jun Zhang, Hongyan Zhou, Fang Sun, Ping Yang, Kailu Li, 管春香, Jiaxiu He, Zhao Zhong, Shihui Sun, Qi Wu et al. · 2026 · Cell Communication and Signaling
  23. ApoE lipidation state directs immunometabolic reprogramming of human microglia
    Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer et al. · 2026 · Alzheimer s & Dementia
  24. Genome-wide CRISPR screen reveals that Wnt signaling regulates lipid accumulation in APOE4 oligodendrocytes
    Leyla Anne Akay, Anna Bright, Daiyun Dong, Ethan D. Smith, Robert C. Hurt, Carles A. Boix, Kate Louderback, Janine Medrano, Dingcheng Sun, Haonan Lin et al. · 2026 · Cell stem cell
  25. Apolipoprotein E4 and immune dysfunction in Alzheimer’s disease: mechanisms and therapeutic implications
    Hao Shi, Yang Zhao, Zhu Wei, Wang Yan-jiang, Xian-Le Bu · 2026 · Trends in Neurosciences
  26. Glial lipid reprogramming in brain aging: Lipid identity, organelle stress, and redox vulnerability
    Mandeep Rana, Wen‐Chin Ko, Kunal Nepali, Chiung-Yuan Ko, Ting‐Lin Yen, Jing‐Shiun Jan, Rajeev Taliyan, Ching-Hao Li, Chih‐Hao Yang · 2026 · Redox Biology
  27. Immunometabolic dysregulation of reactive microglia and astrocytes in neurodegenerative diseases: Mechanistic insights and therapeutic implications
    Cheng Gao, Ran Shi, Xianliang Jiang, Hui Chai, Xiao He · 2026 · Journal of the Neurological Sciences
  28. APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics
    Cuní-López, Carla, Root, Jessica T., Hao, Ying, Blomberg, Niek, Koppes-den Hertog, Sascha J., Sacks, Dylan, Trujillo, Amber E., Ghirlando, Rodolfo, Kowal, Isabelle, Epstein, Jacob et al. · 2026 · Nature Communications