The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application
Open accessAbstract
Age-related macular degeneration (AMD) causes severe visual impairment due in part to age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that autologous human induced pluripotent stem cells (hiPSCs) may represent a useful cell source for the generation of graft RPE. We generated hiPSC-derived RPE (hiPSC-RPE) cell sheets optimized to meet clinical use requirements, including quality, quantity, consistency, and safety. These cell sheets are generated as a monolayer of cells without any artificial scaffolds, express typical RPE markers, form tight junctions that exhibit polarized secretion of growth factors, and show phagocytotic ability and gene-expression patterns similar to those of native RPE. Additionally, upon transplantation, autologous nonhuman primate iPSC-RPE cell sheets showed no immune rejection or tumor formation. These results suggest that autologous hiPSC-RPE cell sheets may serve as a useful form of graft for use in tissue replacement therapy for AMD.
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Mutations in RPE65 cause Leber's congenital amaurosis
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Cited by
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Sharma, A., Sances, S., Workman, M. J., & Svendsen, C. N. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.011 · Cited by 296
A Comparative View on Human Somatic Cell Sources for iPSC Generation
Raab, S., Klingenstein, M., Liebau, S., & Linta, L. (2014) · Stem Cells International · doi:10.1155/2014/768391 · Cited by 263
Paek, J., Park, S. E., Lu, Q., Park, K.-T., Cho, M., Oh, J. M., Kwon, K. W., Yi, Y.-S., Song, J. W., Edelstein, H. I., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00686 · Cited by 238
Influence of donor age on induced pluripotent stem cells
Lo Sardo, V., Ferguson, W., Erikson, G. A., Topol, E. J., Baldwin, K. K., & Torkamani, A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3749 · Cited by 223
HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
Sugita, S., Mandai, M., Hirami, Y., Takagi, S., Maeda, T., Fujihara, M., Matsuzaki, M., Yamamoto, M., Iseki, K., Hayashi, N., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072217 · Cited by 190
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Metadata
- Authors
- Kamao, H., Mandai, M., Okamoto, S., Sakai, N., Suga, A., Sugita, S., Kiryu, J., & Takahashi, M.
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 2
- Issue
- 2
- Pages
- 205-218
- ISSN
- 2213-6711 (ISSN-L)
- OpenAlex
- W2124789204
- Cited by
- 592
- References
- 6
- FWCI
- 33.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kamao, H., Mandai, M., Okamoto, S., Sakai, N., Suga, A., Sugita, S., Kiryu, J., & Takahashi, M. (2014). Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2013.12.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
