The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application
Open accessAbstract
Age-related macular degeneration (AMD) causes severe visual impairment due in part to age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that autologous human induced pluripotent stem cells (hiPSCs) may represent a useful cell source for the generation of graft RPE. We generated hiPSC-derived RPE (hiPSC-RPE) cell sheets optimized to meet clinical use requirements, including quality, quantity, consistency, and safety. These cell sheets are generated as a monolayer of cells without any artificial scaffolds, express typical RPE markers, form tight junctions that exhibit polarized secretion of growth factors, and show phagocytotic ability and gene-expression patterns similar to those of native RPE. Additionally, upon transplantation, autologous nonhuman primate iPSC-RPE cell sheets showed no immune rejection or tumor formation. These results suggest that autologous hiPSC-RPE cell sheets may serve as a useful form of graft for use in tissue replacement therapy for AMD.
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HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
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A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity
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Metadata
- Authors
- Kamao, H., Mandai, M., Okamoto, S., Sakai, N., Suga, A., Sugita, S., Kiryu, J., & Takahashi, M.
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 2
- Issue
- 2
- Pages
- 205-218
- ISSN
- 2213-6711 (ISSN-L)
- OpenAlex
- W2124789204
- Cited by
- 592
- References
- 6
- FWCI
- 33.22
- Type
- journal article
- Language
- en
- Open access
- gold
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