The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Synthesis of ent-25-hydroxycholesterol
Abstract
25-Hydroxycholesterol (25-HC) appears to play a role in several important biological processes, including regulating cellular cholesterol levels and promoting apoptosis. However, in most cases the mechanisms by which 25-HC elicits its biological effects are not known. Insights into mechanisms of 25-HC action can be gained by studying the activity of its enantiomer (ent-25-HC). ent-25-HC is physically and chemically identical to 25-HC; however, 25-HC and ent-25-HC can be distinguished in chiral environments, like a protein binding site. In order to probe the mechanisms of 25-HC action, we have synthesized the enantiomer of 25-HC (ent-25-HC).
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We further evaluated the IL-1β-inducing activity of ent-25-HC, the inactive enantiomer of 25-HC [74], and found that ent-25HC exhibited only very weak IL-1β-inducing activity and was at least an order of magnitude less potent than 25-HC (Fig. 5d).”
From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [74]
In the citing paper
“ent-25-HC, the inactive enantiomer of 25-HC [74]”
From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [74]
Citations
Cites
Biological Activity of Some Oxygenated Sterols
Kandutsch, A. A., Chen, H. W., & Heiniger, H.-J. (1978) · Science · doi:10.1126/science.663671 · Cited by 571
Brown, M. S., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42106-6 · Cited by 413
Lund, E. G., Kerr, T. A., Sakai, J., Li, W.-P., & Russell, D. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34316 · Cited by 335
Kandutsch, A. A., & Chen, H. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42218-7 · Cited by 283
Inhibition of cell growth by oxygenated derivatives of cholesterol
CHEN, H. W., KANDUTSCH, A. A., & WAYMOUTH, C. (1974) · Nature · doi:10.1038/251419a0 · Cited by 219
Theunissen, J. J. H., Jackson, R. L., Kempen, H. J. M., & DEMEL, R. A. (1986) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(86)90499-2 · Cited by 124
Activation of Membrane Cholesterol by Displacement from Phospholipids
Lange, Y., Ye, J., & Steck, T. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507149200 · Cited by 82
Westover, E. J., & Covey, D. F. (2004) · The Journal of Membrane Biology · doi:10.1007/s00232-004-0714-7 · Cited by 73
Self-citationKauffman, J. M., Westerman, P. W., & Carey, M. C. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32042-3 · Cited by 60
25-Hydroxysterols increase the permeability of liposomes to Ca2+ and other cations
Holmes, R. P., & Yoss, N. L. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90067-1 · Cited by 57
Cited by
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01869-3 · Cited by 121
Self-citationIzumi, Y., Cashikar, A. G., Krishnan, K., Paul, S. M., Covey, D. F., Mennerick, S. J., & Zorumski, C. F. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1502-21.2021 · Cited by 53
Self-citation
Metadata
- Authors
- Westover, E. J., & Covey, D. F.
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 71
- Issue
- 6
- Pages
- 484-488
- ISSN
- 0039-128X
- Cited by
- 19
- References
- 13
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Synthesis of ent-25-hydroxycholesterol. https://app.cochat.ai/papers/10.1016/j.steroids.2006.01.007
- The paper
- Westover, E. J., & Covey, D. F. (2006). Synthesis of ent-25-hydroxycholesterol. Steroids. https://doi.org/10.1016/j.steroids.2006.01.007
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
