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Biological Activity of Some Oxygenated Sterols
Abstract
A group of oxygenated sterols has been identified as potent and specific inhibitors of sterol biosynthesis. The ability of these compounds to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated sterol rather than by cholesterol. The nature of the regulatory sterol may vary in different cells with their specific requirements for cholesterol as a structural component or as a precursor of other steroid products. The use of oxygenated sterols to block sterol synthesis in cultured cells provides new information regarding the role of sterol in cell membrane structure and function. For example, de novo sterol synthesis is required for DNA synthesis and cell division by some cultured cells. Studies with cultured cells, and with rats and mice in vivo, suggest that oxygenated sterols could be of value in the treatment of several important human diseases.
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Cited by
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,591
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3137 · Cited by 1,233
INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS
Elbein, A. D. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002433 · Cited by 1,122
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842
Metadata
- Authors
- Kandutsch, A. A., Chen, H. W., & Heiniger, H.-J.
- Venue
- Science
- Published
- 1978-08-11
- Volume
- 201
- Issue
- 4355
- Pages
- 498-501
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078406520
- Cited by
- 571
- References
- 0
- FWCI
- 55.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kandutsch, A. A., Chen, H. W., & Heiniger, H.-J. (1978). Biological Activity of Some Oxygenated Sterols. Science. https://doi.org/10.1126/science.663671
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