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Modulation of Binding of DNA to the C-Terminal Domain of p53 by Acetylation
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“Acetylation of lysine residues (K372/K373/K381/K382) in an isolated CTD peptide results in decreased DNA-binding,34 consistent with the important role played by these residues in modulating interactions between p53 and DNA.”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [34]
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Cites
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DNA damage activates p53 through a phosphorylation–acetylation cascade
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p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage
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Cited by
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications
Yang, X.-J., & Seto, E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.002 · Cited by 1,006
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
Uversky, V. N., Davé, V., Iakoucheva, L. M., Malaney, P., Metallo, S. J., Pathak, R. R., & Joerger, A. C. (2014) · Chemical Reviews · doi:10.1021/cr400713r · Cited by 288
A Nuclear Phosphoinositide Kinase Complex Regulates P53
Choi, S., Chen, M., Cryns, V. L., & Anderson, R. A. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0297-2 · Cited by 106
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 30
Metadata
- Authors
- Friedler, A., Veprintsev, D. B., Freund, S. M. V., von Glos, K. I., & Fersht, A. R.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 13
- Issue
- 4
- Pages
- 629-636
- ISSN
- 0969-2126
- Cited by
- 81
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3029 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- Medical Research Council
- Cancer Research UK
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- Friedler, A., Veprintsev, D. B., Freund, S. M. V., von Glos, K. I., & Fersht, A. R. (2005). Modulation of Binding of DNA to the C-Terminal Domain of p53 by Acetylation. Structure. https://doi.org/10.1016/j.str.2005.01.020
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