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Cited by 101Adrenal and Paraganglionic TumorsPituitary Gland Disorders and TreatmentsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Adrenalectomy may improve cardiovascular and metabolic impairment and ameliorate quality of life in patients with adrenal incidentalomas and subclinical Cushing’s syndrome

Iacobone, Maurizio, Citton, Marilisa, Viel, Giovanni, Boetto, Riccardo, Bonadio, Italo, Mondi, Isabella, Tropea, Saveria, Nitti, Donato, Favia, Gennaro·2012·Surgery
DOI 10.1016/j.surg.2012.08.054
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Abstract

Background Adrenalectomy represents the definitive treatment in clinically evident Cushing's syndrome; however, the most appropriate treatment for patients with subclinical Cushing's syndrome (SCS) with an adrenal incidentaloma remains controversial. This study was aimed to assess whether adrenalectomy may improve cardiovascular and metabolic impairment and quality of life compared with conservative management.Methods Twenty patients with adrenal incidentaloma underwent laparoscopic adrenalectomy for SCS, whereas 15 were managed conservatively. Hormonal laboratory parameters of corticosteroid secretion, arterial blood pressure (BP), glycometabolic profile, and quality of life (by the SF-36 questionnaire) were compared at baseline and the end of follow-up.Results The 2 groups were equivalent concerning all the examined parameters at baseline. In the operative group, laboratory corticosteroid parameters normalized in all patients but not in the conservative-management group (P < .001). In operated patients, a decrease in BP occurred in 53% of patients, glycometabolic control improved in 50%, and body mass index decreased; in contrast, no improvement or some worsening occurred in the conservative-management group (P < .01). SF-36 evaluation improved in the operative group (P < .05).Conclusion Adrenalectomy can be more beneficial than conservative management in SCS and may achieve remission of laboratory hormonal abnormalities and improve BP, glycemic control, body mass index, and quality of life.

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Crossref · 10.1016/j.surg.2012.08.054

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Metadata

Authors
Iacobone, M., Citton, M., Viel, G., Boetto, R., Bonadio, I., Mondi, I., Tropea, S., Nitti, D., & Favia, G.
Affiliations
University of Padua (IT)
Corresponding author
Iacobone, Maurizio
ORCID
Venue
Surgery
Publisher
Elsevier BV
Published
2012-12
Volume
152
Issue
6
Pages
991-997
ISSN
0039-6060 (ISSN-L)
DOI
10.1016/j.surg.2012.08.054
OpenAlex
W2008606130
Cited by
101
References
28
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 12
FWCI
8.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenalectomy, adrenal incidentaloma, subclinical Cushing's syndrome, conservative treatment, cardiovascular dysfunction, metabolic dysfunction, quality of life, blood pressure, body mass index, corticosteroid secretion, laparoscopic adrenalectomy
MeSH terms
Adrenal Cortex Neoplasms, Adrenalectomy, Adult, Aged, Blood Glucose, Blood Pressure, Cushing Syndrome, Female, Glycated Hemoglobin, Humans, Lipids, Male, Middle Aged, Quality of Life, Body Mass Index, Adrenocortical Adenoma, Metabolic Syndrome, Incidental Findings

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