The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Adrenalectomy may improve cardiovascular and metabolic impairment and ameliorate quality of life in patients with adrenal incidentalomas and subclinical Cushing’s syndrome
Abstract
Background Adrenalectomy represents the definitive treatment in clinically evident Cushing's syndrome; however, the most appropriate treatment for patients with subclinical Cushing's syndrome (SCS) with an adrenal incidentaloma remains controversial. This study was aimed to assess whether adrenalectomy may improve cardiovascular and metabolic impairment and quality of life compared with conservative management.Methods Twenty patients with adrenal incidentaloma underwent laparoscopic adrenalectomy for SCS, whereas 15 were managed conservatively. Hormonal laboratory parameters of corticosteroid secretion, arterial blood pressure (BP), glycometabolic profile, and quality of life (by the SF-36 questionnaire) were compared at baseline and the end of follow-up.Results The 2 groups were equivalent concerning all the examined parameters at baseline. In the operative group, laboratory corticosteroid parameters normalized in all patients but not in the conservative-management group (P < .001). In operated patients, a decrease in BP occurred in 53% of patients, glycometabolic control improved in 50%, and body mass index decreased; in contrast, no improvement or some worsening occurred in the conservative-management group (P < .01). SF-36 evaluation improved in the operative group (P < .05).Conclusion Adrenalectomy can be more beneficial than conservative management in SCS and may achieve remission of laboratory hormonal abnormalities and improve BP, glycemic control, body mass index, and quality of life.
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“Several studies have reported the outcome of surgical intervention but most involve small numbers and are retrospective, uncontrolled, and lack randomization (230,243,250-253,255) (Table 7).”
From Adrenal incidentaloma (2020) · cites this paper as [251]
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“In contrast, other studies have found more conflicting results, especially concerning obesity, osteoporosis, and dyslipidemia.6,23 These discrepancies might be attributable to methodologic reasons (small sample sizes, retrospective design, lack of control group, analysis bias)6,10,22; an accepted definition of SCS is…”
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“Several studies have reported the outcome of surgical intervention but most involve small numbers and are retrospective, uncontrolled, and lack randomization (230,243,250-253,255) (Table 7).”
BackgroundElhassan, Y. S., Alahdab, F., Prete, A., Delivanis, D. A., Khanna, A., Prokop, L., Murad, M. H., O'Reilly, M. W., Arlt, W., & Bancos, I. (2019) · Annals of Internal Medicine · doi:10.7326/m18-3630 · Cited by 263
Long-term follow-up in adrenal incidentalomas: an Italian multicenter study
Morelli, V., Reimondo, G., Giordano, R., Della Casa, S., Policola, C., Palmieri, S., Salcuni, A. S., Dolci, A., Mendola, M., Arosio, M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3527 · Cited by 223
“Some studies (22-26), but not all (27, 28), reported an improvement of the metabolic complications of SH (AH, weight, and glycemic control) and of the quality of life after adrenalectomy, while a worsening of these conditions in untreated patients.”
Background
Metadata
- Authors
- Iacobone, M., Citton, M., Viel, G., Boetto, R., Bonadio, I., Mondi, I., Tropea, S., Nitti, D., & Favia, G.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Iacobone, Maurizio
- Venue
- Surgery
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 152
- Issue
- 6
- Pages
- 991-997
- ISSN
- 0039-6060 (ISSN-L)
- OpenAlex
- W2008606130
- Cited by
- 101
- References
- 28
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 12
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgery (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenalectomy, adrenal incidentaloma, subclinical Cushing's syndrome, conservative treatment, cardiovascular dysfunction, metabolic dysfunction, quality of life, blood pressure, body mass index, corticosteroid secretion, laparoscopic adrenalectomy
- MeSH terms
- Adrenal Cortex Neoplasms, Adrenalectomy, Adult, Aged, Blood Glucose, Blood Pressure, Cushing Syndrome, Female, Glycated Hemoglobin, Humans, Lipids, Male, Middle Aged, Quality of Life, Body Mass Index, Adrenocortical Adenoma, Metabolic Syndrome, Incidental Findings
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