The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Corneal Neovascularization: An Anti-VEGF Therapy Review
Open accessAbstract
Corneal neovascularization is a serious condition that can lead to a profound decline in vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity, and may lead to inflammation and edema. Corneal neovascularization occurs when the balance between angiogenic and antiangiogenic factors is tipped toward angiogenic molecules. Vascular endothelial growth factor (VEGF), one of the most important mediators of angiogenesis, is upregulated during neovascularization. In fact, anti-VEGF agents have efficacy in the treatment of neovascular age-related macular degeneration, diabetic retinopathy, macular edema, neovascular glaucoma, and other neovascular diseases. These same agents have great potential for the treatment of corneal neovascularization. We review some of the most promising anti-VEGF therapies, including bevacizumab, VEGF trap, siRNA, and tyrosine kinase inhibitors.
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Deng, Y., Wang, C. C., Choy, K. W., Du, Q., Chen, J., Wang, Q., Li, L., Chung, T. K. H., & Tang, T. (2014) · Gene · doi:10.1016/j.gene.2013.12.019 · Cited by 301
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Shi, H., Zhu, Y., Xing, C., Li, S., Bao, Z., Lei, L., Lin, D., Wang, Y., Chen, H., & Xu, X. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122081 · Cited by 29
Metadata
- Authors
- Chang, J.-H., Garg, N. K., Lunde, E., Han, K.-Y., Jain, S., & Azar, D. T.
- Venue
- Survey of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 57
- Issue
- 5
- Pages
- 415-429
- ISSN
- 0039-6257 (ISSN-L)
- OpenAlex
- W2038451782
- Cited by
- 381
- References
- 93
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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