Cited by 441Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryOcular Infections and Treatments

Ocular drug delivery: present innovations and future challenges

Gote, Vrinda, Sikder, Sadia, Sicotte, Jeff, Pal, Dhananjay·2019·The Journal of Pharmacology and Experimental Therapeutics

Abstract

Ocular drug delivery has always been a challenge for ophthalmologists and drug-delivery scientists due to the presence of various anatomic and physiologic barriers. Inimitable static and dynamic ocular barriers not only exclude the entry of xenobiotics but also discourage the active absorption of therapeutic agents. Designing an ideal delivery scheme should include enhanced drug bioavailability and controlled release of drug at the site of action, which can overcome various ocular barriers. Conventional ophthalmic medications include the use of topical eye drops and intravitreal injections of anti-vascular endothelial growth factor agent for treatment of anterior and posterior segment disorders, respectively. Current inventions for anterior ocular segment disorders such as punctum plugs, ocular implants, drug-eluting contact lenses, and ocular iontophoresis represent state-of-the-art inventions for sustained and controlled drug release. Parallel efforts for ocular drug delivery technologies for back of the eye disorders have resulted in the approval of various intravitreal implants. Novel drug-delivery technologies, including nanoparticles, nanomicelles, dendrimers, microneedles, liposomes, and nanowafers, are increasingly studied for anterior and posterior disorders. To achieve patient compliance for back of the eye disorders, novel approaches for noninvasive delivery of potent therapeutic agents are on the rise. In this review article, we discuss past successes, present inventions, and future challenges in ocular drug-delivery technologies. This expert opinion also discusses the future challenges for ocular drug-delivery systems and the clinical translatable potential of nanotechnology from benchtop to bedside.

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Crossref · 10.1124/jpet.119.256933

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Authors
Gote, V., Sikder, S., Sicotte, J., & Pal, D.
Affiliations
University of Missouri–Kansas City (US)
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
2019-09
Volume
370
Issue
3
Pages
602-624
ISSN
0022-3565 (ISSN-L)
OpenAlex
W2944704306
Cited by
441
References
195
Citations by year
2026: 49 · 2025: 75 · 2024: 69 · 2023: 84 · 2022: 65 · 2021: 56 · 2020: 38 · 2019: 4 · 2012: 1
FWCI
17.40
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Missouri
  • Harvard University
  • University of Missouri-Kansas City
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
ocular drug delivery, ocular barriers, drug bioavailability, controlled drug release, intravitreal implant, drug-eluting contact lenses, nanoparticles, nanomicelles, dendrimers, microneedles, liposomes, anti-VEGF therapy, anterior segment disorders, non-invasive drug delivery
MeSH terms
Animals, Drug Compounding, Eye, Humans, Drug Delivery Systems, Intravitreal Injections, Administration, Ophthalmic

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