Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

Mandal, Abhirup; Bisht, Rohit; Rupenthal, Ilva D.; Mitra, Ashim K.

doi:10.1016/j.jconrel.2017.01.012

Cited by 481Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryOcular Surface and Contact Lens

Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

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Mandal, Abhirup, Bisht, Rohit, Rupenthal, Ilva D., Mitra, Ashim K.·2017·Journal of Controlled Release

DOI 10.1016/j.jconrel.2017.01.012PMC PMC5319397

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Abstract

Effective intraocular drug delivery poses a major challenge due to the presence of various elimination mechanisms and physiological barriers that result in low ocular bioavailability after topical application. Over the past decades, polymeric micelles have emerged as one of the most promising drug delivery platforms for the management of ocular diseases affecting the anterior (dry eye syndrome) and posterior (age-related macular degeneration, diabetic retinopathy and glaucoma) segments of the eye. Promising preclinical efficacy results from both in-vitro and in-vivo animal studies have led to their steady progression through clinical trials. The mucoadhesive nature of these polymeric micelles results in enhanced contact with the ocular surface while their small size allows better tissue penetration. Most importantly, being highly water soluble, these polymeric micelles generate clear aqueous solutions which allows easy application in the form of eye drops without any vision interference. Enhanced stability, larger cargo capacity, non-toxicity, ease of surface modification and controlled drug release are additional advantages with polymeric micelles. Finally, simple and cost effective fabrication techniques render their industrial acceptance relatively high. This review summarizes structural frameworks, methods of preparation, physicochemical properties, patented inventions and recent advances of these micelles as effective carriers for ocular drug delivery highlighting their performance in preclinical studies.

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Research works printed but not linked: 3

[11]Ahuja M Dhake AS Sharma SK Majumdar DK Topical ocular delivery of NSAIDs AAPS J 2008 10 229 241 18437583 PMC2751374
[50]Tadros TF Microemulsions Applied Surfactants 2005 Wiley-VCH Verlag GmbH & Co. KGaA 309 334
[134]SARL OT Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca (Emerald) ClinicalTrials.gov 2016 Bethesda (MD) National Library of Medicine (US)

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Authors: Mandal, A., Bisht, R., Rupenthal, I. D., & Mitra, A. K.
Affiliations: University of Missouri–Kansas City (US)
University of Auckland (NZ)
Corresponding author: Mitra, Ashim K.
ORCID: Mandal, Abhirup
Bisht, Rohit
Rupenthal, Ilva D.
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2017-02
Volume: 248
Pages: 96-116
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2017.01.012
PMC: PMC5319397
OpenAlex: W2575367849
Cited by: 481
References: 148
Citations by year: 2026: 32 · 2025: 47 · 2024: 58 · 2023: 80 · 2022: 61 · 2021: 64 · 2020: 45 · 2019: 46 · 2018: 29 · 2017: 19
FWCI: 3.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01 EY09171-14, NIH R01 EY10659-12)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
Keywords: polymeric micelles, ocular drug delivery, intraocular drug delivery, dry eye, age-related macular degeneration, diabetic retinopathy, glaucoma, mucoadhesion, eye drops, controlled drug release, physicochemical properties, preclinical research, patents
MeSH terms: Animals, Biological Availability, Drug Carriers, Pharmaceutical Preparations, Eye, Eye Diseases, Humans, Micelles, Ophthalmic Solutions, Polymers, Solubility, Dry Eye Syndromes, Drug Delivery Systems, Administration, Ophthalmic

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Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

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