The DOI matches its Crossref record; 208 of the 220 references it cites were found in a registry or an index.
Organic anion transporter (Slc22a) family members as mediators of toxicity
Abstract
Exposure of the body to toxic organic anions is unavoidable and occurs from both intentional and unintentional sources. Many hormones, neurotransmitters, and waste products of cellular metabolism, or their metabolites, are organic anions. The same is true for a wide variety of medications, herbicides, pesticides, plant and animal toxins, and industrial chemicals and solvents. Rapid and efficient elimination of these substances is often the body's best defense for limiting both systemic exposure and the duration of their pharmacological or toxicological effects. For organic anions, active transepithelial transport across the renal proximal tubule followed by elimination via the urine is a major pathway in this detoxification process. Accordingly, a large number of organic anion transport proteins belonging to several different gene families have been identified and found to be expressed in the proximal nephron. The function of these transporters, in combination with the high volume of renal blood flow, predisposes the kidney to increased toxic susceptibility. Understanding how the kidney mediates the transport of organic anions is integral to achieving desired therapeutic outcomes in response to drug interactions and chemical exposures, to understanding the progression of some disease states, and to predicting the influence of genetic variation upon these processes. This review will focus on the organic anion transporter (OAT) family and discuss the known members, their mechanisms of action, subcellular localization, and current evidence implicating their function as a determinant of the toxicity of certain endogenous and xenobiotic agents.
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“These gene counts represent significant expansions of the SLC22 family, which consists of only 5 genes in humans and mice”
From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Sweet, 2005
In the citing paper
“Both SLC22 and ABC efflux proteins (see above) export metals directly or as glutathione (GSH) conjugates (Leslie et al., 2001;Sweet, 2005), and the urchin genome contains multiple genes in the subfamilies known to be involved in resistance to heavy metal toxicity.”
From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Sweet, 2005
Citations
Cites
The toxicology of mercury—current exposures and clinical manifestations
Clarkson, T. W., Magos, L., & Myers, G. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022471 · Cited by 1,766
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
Enomoto, A., Kimura, H. J., Chairoungdua, A., Shigeta, Y., Jutabha, P., Ho, S., Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., et al. (2002) · Nature · doi:10.1038/nature742 · Cited by 1,535
The three modern faces of mercury.
Clarkson, T. W. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s111 · Cited by 1,012
Blood-Brain Barrier in Physiology and Medicine
Rapoport, S. I. (1976) · Medical Entomology and Zoology · Cited by 889
Adverse Health Effects of Chronic Exposure to Low-Level Cadmium in Foodstuffs and Cigarette Smoke
Satarug, S., & Moore, M. R. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6751 · Cited by 871
Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter
Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., & Endou, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18526 · Cited by 623
Risk assessment of the mycotoxin ochratoxin A.
Kuiper-Goodman, T., & Scott, P. M. (1989) · PubMed · Cited by 544
The SLC22 drug transporter family
Koepsell, H., & Endou, H. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1089-9 · Cited by 521
Ho, S., Sekine, T., Fukushima, J., Kanai, Y., Kobayashi, Y., Goya, T., & Endou, H. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1277 · Cited by 508
Gene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human Kidney
Motohashi, H., Sakurai, Y., Saito, H., Masuda, S., Urakami, Y., Goto, M., Fukatsu, A., Ogawa, O., & Inui, K. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134866 · Cited by 507
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12 of the 220 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Lacy, 1998, Evaluation of toxicity associated with chronic administration of anti-HIV nucleotide analogue adefovir dipivoxil in rats and cynomolgus monkeys, The Toxicologist, 42, 374
- Shimada, 1987, Indirect coupling to Na of p-aminohippurate acid uptake into rat renal basolateral membrane vesicles, Am. J. Physiol.: Renal Physiol., 253, F795
Cited by
Sorted by citations
Items 101–151 of 151
Transporter-mediated Natural Product-Drug Interactions
Bi, Y., Wang, X., Ding, H., He, F., Han, L., & Zhang, Y. (2022) · Planta Medica · doi:10.1055/a-1803-1744 · Cited by 14
“Trans-stimulation assays show that preloading the HEK‑OAT4 cells with glutarate or p-aminohippurate significantly increases the uptake of 6-CF, a known OAT4 substrate [100].”
BackgroundInfluentialLin, C.-C. A., Fan, H.-Y., Kuo, C.-W., & Pao, L. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/967182 · Cited by 13
“Drugs that are transported by OAT1 include nonsteroidal antiinflammatory drugs (NSAIDs), antiviral drugs, antibiotics, diuretics, antineoplasmics, antiepileptics, and antihypertensive agents [20, 28–30].”
BackgroundImplications of the Alternating Access Model for Organic Anion Transporter Kinetics
Eraly, S. A. (2008) · The Journal of Membrane Biology · doi:10.1007/s00232-008-9137-1 · Cited by 12
“…kidney proteins which are responsible for the urinary excretion of a great variety of important drugs (Burckhardt and Burckhardt, 2003; Eraly et al. 2003, 2004; Sweet 2005) and potentially also mediate transport of many physiological regulators (Eraly et al. 2003, 2004; Vallon et al. 2008).”
BackgroundInfluentialLouisse, J., Dorne, J. L. C. M., & Dellafiora, L. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.11.001 · Cited by 13
Bakhiya, N., Batke, M., Laake, J., Monien, B. H., Frank, H., Seidel, A., Engst, W., & Glatt, H. R. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.016964 · Cited by 12
“Moreover, they are involved in the renal accumulation of potentially toxic compounds, such as uremic toxins, mercuric species, and ochratoxin A (Sweet, 2005), as well as reactive sulfuric acid esters (Bakhiya et al.”
BackgroundJanaszkiewicz, A., Tóth, Á., Faucher, Q., Arnion, H., Védrenne, N., Guellec, C. B., Marquet, P., & Meo, F. D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114342 · Cited by 14
Hagos, Y., Hundertmark, P., Shnitsar, V., Marada, V. V. V. R., Wulf, G. G., & Burckhardt, G. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00467.2014 · Cited by 10
The Biology and Function of Transporters
Scherrmann, J. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00123-1 · Cited by 10
Moulis, J., Bourguignon, J., & Catty, P. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781849739979-00695 · Cited by 11
Sugio, K., Inoda, D., Masuda, M., Azumaya, I., Sasaki, S., Shimono, K., Ganapathy, V., & Miyauchi, S. (2018) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2018.10.004 · Cited by 9
Expression and clinical significance of organic cation transporter family in glioblastoma multiforme
Lian, Q., Xiao, S., Wang, Y., Wang, H., & Xie, D. (2021) · Irish Journal of Medical Science · doi:10.1007/s11845-021-02675-3 · Cited by 8
Assessing a Potential Role of Host Pannexin 1 during Chlamydia trachomatis Infection
McKuen, M. J., Dahl, G., & Fields, K. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063732 · Cited by 7
“to mediate inhibition of OAT [42] and MDR [15] transporters.”
BackgroundInfluentialRenal pathologies in giant toads (Bufo marinus) vary with land use
McCoy, K. A., HOANG, L., GUILLETTEJR, L., & Mary, C. M. S. (2008) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.09.008 · Cited by 7
Prediction of Acute Toxicity in HPCT-1E3 Hepatocytoma Cells with Liver-like Transport Activities
Kneuer, C., Lakoma, C., & Honscha, W. (2007) · Alternatives to Laboratory Animals · doi:10.1177/026119290703500410 · Cited by 7
Tobin, J. D., Robinson, C. N., Luttrell-Williams, E. S., Landry, G. M., Dwyer, D. S., & McMartin, K. E. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac091 · Cited by 6
Pak, Y. A., Posada, M. M., Bacon, J. A., Long, A. J., Annes, W. F., Witcher, J. W., Mitchell, M. I., Tirona, R. G., Hall, S. D., & Hillgren, K. M. (2023) · Pharmaceutical Research · doi:10.1007/s11095-022-03464-y · Cited by 6
“…compound into cells without reabsorption back into plasma, which is consistent with the location and unidirectional nature on the OAT1 transporter [31–33], the low calculated log of octanol/water partition coefficient of 1 and poor passive permeability of LY404039 in the vector control (0.0396…”
InfluentialGe, X., Zhao, J., Ren, W., Zhou, Y., Chen, Y., Jiang, S.-R., Tian-zhu, J., Gao, H. J., & Zhang, F. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116014 · Cited by 6
Tohyama, K., Chisaki, I., Takai, Y., Handa, Y., Miyamoto, M., & Amano, N. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz093 · Cited by 6
Qin, Z., Zhao, L., Hu, H., Jiang, H., Yu, L., & Zeng, S. (2016) · Xenobiotica · doi:10.1080/00498254.2016.1211774 · Cited by 4
“…a member of solute carriers (SLC) superfamily, hOAT1 (SLC22A6) is mainly distributed on the basolateral membrane of proximal tubule in human kidney (Sweet, 2005), where it mediates the absorption of a variety of endogenous and xenogenous organic anions, including cyclic nucleotide, folic acid,…”
BackgroundLi, Y., Deng, S., Zhao, Y., Liu, L., & Zhao, R. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7559 · Cited by 4
Kimura, O., Tsukagoshi, K., Hayasaka, M., & Endo, T. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00850.x · Cited by 3
Expression and Function of Renal Organic Anion Transporters in Cholestasis
Brandoni, A., & Mnica, A. (2012) · InTech eBooks · doi:10.5772/36935 · Cited by 3
“For example, Oat3 displays a moderately high affinity for ES, whereas Oat1 interacts little with ES (Sweet, 2005; Brandoni & Torres, 2010; Torres et al., 2008; Burckhardt & Burckhardt, 2011).”
BackgroundCurrent Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs)
Li, Z. (2012) · Journal of Pharmacogenomics & Pharmacoproteomics · doi:10.4172/2153-0645.1000e127 · Cited by 3
“Due to their localizations at the boundary epithelia, they are also involved in the renal excretion and detoxification of a variety of endogenous compounds, including hormones and neurotransmitter metabolites [27].”
BackgroundFLUID AND ELECTROLYTE HOMEOSTASIS
Kone, B. C. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3291-5.50014-7 · Cited by 3
Jones, D. P., & Chesney, R. W. (2009) · Springer eBooks · doi:10.1007/978-3-540-76341-3_53 · Cited by 3
Nethathe, B., Phaswane, R. M., Abera, A. B., & Naidoo, V. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250408 · Cited by 2
Drug Transport Mechanisms and their Impact on the Disposition and Effects of Drugs
Scherrmann, J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-417205-0.00026-2 · Cited by 2
Nethathe, B., Abera, A. B., & Naidoo, V. (2020) · PeerJ · doi:10.7717/peerj.10422 · Cited by 2
Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinomaPreprint
Thind, A. S., Ashford, B., Strbenac, D., Gupta, R., Clark, J. R., Iyer, N. G., Mitchell, J., Lee, J., Mueller, S. A., Minaei, E., et al. (2022) · medRxiv · doi:10.1101/2022.01.10.22269035 · Cited by 3
Caffeic Acid and Organic Anion Transporters hOAT1 and hOAT3
Uwai, Y. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00100-5 · Cited by 1
Role of Transporters in Hyperuricemia
Zhang, S., Wang, J., Wang, S., Dai, Z., Zhang, L., & Xue, F. (2024) · Physiology · doi:10.5772/intechopen.114991 · Cited by 1
Ridtitid, W., Wongnawa, M., Mahatthanatrakul, W., Pattanawongsa, A., Bumrungwong, N., & Sunbhanich, M. (2006) · PSU Knowledge Bank (Prince of Songkla University) · Cited by 1
Wang, L. (2013) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/nk8t-g774
“1) and mediate the movement of substrate molecules from the blood into the cells via dicarboxylate/organic anion exchange (2-4).”
BackgroundInfluentialToxicological Relevance of Transporters
Maeng, H., & Chung, S. (2007) · Toxicological Research · doi:10.5487/tr.2007.23.1.001
Phelps, M. A. (2005) · OhioLink ETD Center (Ohio Library and Information Network)
Yacovino, L. L. (2012) · PubMed · doi:10.7282/t3b56hr8
rats and mice is regulated by sex hormones Renal expression of organic anion transporter OAT2 in
Bahn, A., Burckhardt, G., Sabolić, I., Ljubojević, M., Balen, D., Breljak, D., Kušan, M., & Anzai, N. (2016)
High-quality genome assemblies uncover caste-specific long non-coding RNAs in antsPreprint
Shields, E. J., & Bonasio, R. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/155119
Drug Transport Mechanisms and their Impact on the Disposition and Effects of Drugs
Scherrmann, J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374194-3.00034-2
Sweet, D. H. (2022) · Wiley eBooks · doi:10.1002/9781119739883.ch15
Molekulare Mechanismen der Pharmakokinetik
(2007) · Springer eBooks · doi:10.1007/978-3-540-48245-1_2
Farthing, C. A. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/501d-jc95
“The SLC22 family contains 25 members subdivided into three subgroups: organic cation transporters (OCTs), organic anion transporters (OATs), and organic cation/carnitine transporters (OCTNs) (Sweet, 2005; Sweet, 2010; VanWert et al., 2010).”
BackgroundSaito, H., & Saito, H. (2009) · Institutional Repositories DataBase (IRDB)
BindingDB (2016) · UC San Diego · doi:10.7270/q2tf003w
The importance of charged amino acids in the human Organic Anion Transporter 1
Rizwan, A. (2007) · eDiss (Georg-August-Universität Göttingen)
Metadata
- Authors
- Sweet, D. H.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Sweet, Douglas H.
- ORCID
- Sweet, Douglas H.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 204
- Issue
- 3
- Pages
- 198-215
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2124824529
- Cited by
- 150
- References
- 220
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 12
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- organic anion transporters, proximal tubule, drug toxicity, xenobiotic transport, drug interactions, subcellular localization
- MeSH terms
- Animals, Pharmaceutical Preparations, Humans, Kidney, Toxins, Biological, Organic Anion Transporters, Drug-Related Side Effects and Adverse Reactions
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