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Cited by 301Arsenic contamination and mitigationHeavy Metal Exposure and ToxicityChromium effects and bioremediation

Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: Review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh

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Chen, Yu, Parvez, Faruque, Gamble, Mary, Islam, Tariqul, Ahmed, Alauddin, Argos, Maria, Graziano, Joseph H., Ahsan, Habibul·2009·Toxicology and Applied Pharmacology
DOI 10.1016/j.taap.2009.01.010PMC PMC3904798
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Abstract

The contamination of groundwater by arsenic in Bangladesh is a major public health concern affecting 35-75 million people. Although it is evident that high levels (>300 microg/L) of arsenic exposure from drinking water are related to adverse health outcomes, health effects of arsenic exposure at low-to-moderate levels (10-300 microg/L) are not well understood. We established the Health Effects of Arsenic Longitudinal Study (HEALS) with more than 20,000 men and women in Araihazar, Bangladesh, to prospectively investigate the health effects of arsenic predominantly at low-to-moderate levels (0.1 to 864 microg/L, mean 99 microg/L) of arsenic exposure. Findings to date suggest adverse effects of low-to-moderate levels of arsenic exposure on the risk of pre-malignant skin lesions, high blood pressure, neurological dysfunctions, and all-cause and chronic disease mortality. In addition, the data also indicate that the risk of skin lesion due to arsenic exposure is modifiable by nutritional factors, such as folate and selenium status, lifestyle factors, including cigarette smoking and body mass index, and genetic polymorphisms in genes related to arsenic metabolism. The analyses of biomarkers for respiratory and cardiovascular functions support that there may be adverse effects of arsenic on these outcomes and call for confirmation in large studies. A unique strength of the HEALS is the availability of outcome data collected prospectively and data on detailed individual-level arsenic exposure estimated using water, blood and repeated urine samples. Future prospective analyses of clinical endpoints and related host susceptibility will enhance our knowledge on the health effects of low-to-moderate levels of arsenic exposure, elucidate disease mechanisms, and give directions for prevention.

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  • Transfer of As to the food chain will remain a long-term risk to human and ecological systems.

    “The transfer of As to the food chain will ultimately remain as long-term risks to human and ecological systems [25].”

    From Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation (2014) · cites this paper as [25]

    The Introduction (page unavailable) identifies long-term arsenic exposure from drinking water as a human public-health hazard. It does not establish transfer through the food chain or a long-term risk to ecological systems; searches for food-chain transfer and food crops found no supporting passage. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Chen, Y., Parvez, F., Gamble, M., Islam, T., Ahmed, A., Argos, M., Graziano, J. H., & Ahsan, H.
Affiliations
  • New York University (US)
  • Columbia University (US)
  • University of Chicago (US)
Corresponding author
Ahsan, Habibul
ORCID
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2009-09
Volume
239
Issue
2
Pages
184-192
ISSN
0041-008X (ISSN-L)
DOI
10.1016/j.taap.2009.01.010
PMC
PMC3904798
OpenAlex
W2083983543
Cited by
301
References
2
Citations by year
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FWCI
15.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Toxicology and Applied Pharmacology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (CA016087, CA014599, ES000260)
  • National Cancer Institute (R01CA102484, CA 014599, CA 016087, R01CA107431, P30CA014599, P30CA016087)
  • National Institute of Environmental Health Sciences (ES-000260, R01ES011601, P42ES010349, P30ES000260, P30-ES09089, P30ES009089)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chromium effects and bioremediation
Keywords
arsenic exposure, groundwater arsenic contamination, arsenic metabolism, neurological disorders, blood pressure, chronic disease mortality, folic acid, selenium, cigarette smoking, body mass index, genetic polymorphism, biomarkers, respiratory function, cardiovascular function, Araihazar
MeSH terms
Arsenic, Bangladesh, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Environmental Exposure, Female, Humans, Intelligence, Longitudinal Studies, Male, Nervous System Diseases, Prospective Studies, Respiratory Tract Diseases, Skin Diseases, Water Pollutants, Chemical, Biomarkers, Arsenic Poisoning

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