The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Atypical E2Fs: new players in the E2F transcription factor family
Open accessAbstract
As major regulators of the cell cycle, apoptosis and differentiation, E2F transcription factors have been studied extensively in a broad range of organisms. The recent identification of atypical E2F family members further expands our structural, functional and molecular view of the cellular E2F activity. Unlike other family members, atypical E2Fs have a duplicated DNA-binding domain and control gene expression without heterodimerization with DP proteins. More recently, knock-out strategies in plants and mammals have pinpointed that atypical E2Fs play a critical role in plant cell size control, endocycle regulation, proliferation, and apoptotic response upon DNA stress. Here, we review the emerging biochemical and genetic data on these unique E2F members and discuss their roles in plant and animal development. Their position at the crossroads between proliferation and DNA stress response marks these novel E2F proteins as interesting study objects in the field of tumor biology.
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Cites
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Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301
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Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315
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The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease
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Cited by
E2F8 is essential for polyploidization in mammalian cells
Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H., & de Bruin, A. (2012) · Nature Cell Biology · doi:10.1038/ncb2585 · Cited by 168
Canonical and atypical E2Fs regulate the mammalian endocycle
Chen, H.-Z., Ouseph, M. M., Li, J., Pécot, T., Chokshi, V., Kent, L., Bae, S., Byrne, M., Duran, C., Comstock, G., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2595 · Cited by 161
Self-citationCarvajal, L. A., Hamard, P.-J., Tonnessen, C., & Manfredi, J. J. (2012) · Genes & Development · doi:10.1101/gad.184911.111 · Cited by 151
E2f8 mediates tumor suppression in postnatal liver development
Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H.-Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85506 · Cited by 95
Self-citationQi, Q.-R., Zhao, X.-Y., Zuo, R.-J., Wang, T.-S., Gu, X.-W., Liu, J.-L., & Yang, Z.-M. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1033593 · Cited by 58
Metadata
- Authors
- Lammens, T., Li, J., Leone, G., & De Veylder, L.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 19
- Issue
- 3
- Pages
- 111-118
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2015003540
- Cited by
- 227
- References
- 6
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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