The E2F transcriptional network: old acquaintances with new faces
Abstract
The E2 factor (E2F) family of transcription factors are downstream targets of the retinoblastoma protein. E2F factors have been known for several years to be important regulators of S-phase entry. Recent studies have improved our understanding of the molecular mechanisms of action used by this transcriptional network. In addition, they have given us an appreciation of the fact that E2F has functions that reach beyond G1/S control and impact cell proliferation in several different ways. The discovery of new family members with unusual properties, the unexpected phenotypes of mutant animals, a diverse collection of biological activities, a large number of new putative target genes and the new modes of transcriptional regulation have all contributed to an increasingly complex view of E2F function. In this review, we will discuss these recent developments and describe how they are beginning to shape a new and revised picture of the E2F transcriptional program.
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The E2F network as well as the Cdk1 and Cdk2 related pathways are associated with anemia, the most prominent and consistent clinical sign of trypanosome infection.
“The E2F network as well as the Cdk1 and Cdk2 related pathways are also associated with anemia which is the most prominent and consistent clinical sign of trypanosome infection (Kaminski et al., 2001; Dimova and Dyson, 2005; Noyes et al., 2011, Hu and Sun, 2016).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Dimova and Dyson, 2005
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- Authors
- Dimova, D. K., & Dyson, N. J.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Dyson, Nicholas J
- ORCID
- Dyson, Nicholas J
- Venue
- Oncogene
- Published
- 2005-04-18
- Volume
- 24
- Issue
- 17
- Pages
- 2810-2826
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2065343028
- Cited by
- 715
- References
- 11
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 10 · 2023: 25 · 2022: 49 · 2021: 43 · 2020: 30 · 2019: 23 · 2018: 29 · 2017: 31 · 2016: 30 · 2015: 30 · 2014: 28 · 2013: 27 · 2012: 34
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA64402, R01CA064402)
- National Institute of General Medical Sciences (GM-53203, R01GM053203)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- E2F transcription factors, retinoblastoma protein, S phase entry, cell proliferation, E2F target genes, transcriptional regulation
- MeSH terms
- Animals, Cell Cycle, DNA Damage, DNA Repair, DNA-Binding Proteins, Transcription Factors, Transcription, Genetic, Cell Cycle Proteins, E2F Transcription Factors
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