The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
ADF/Cofilin: a functional node in cell biology
Open accessAbstract
Recent findings have significantly expanded our understanding of the regulation of actin-depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these well-established regulators of actin dynamics have on cell biology. In this review we discuss new aspects of previously documented regulation, such as phosphorylation, but also cover novel recently established modes of regulation and functions of ADF (also known as destrin)/cofilin. We now understand that their activity responds to a vast array of inputs far greater than previously appreciated and that these proteins not only feed back to the crucially important dynamics of actin, but also to apoptosis cascades, phospholipid metabolism, and gene expression. We argue that this ability to respond to physiological changes by modulating those same changes makes the ADF/cofilin protein family a homeostatic regulator or 'functional node' in cell biology.
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“These findings suggest that the diffusion of WT or S3A cofilin, but not S3E cofilin, was significantly impeded by their binding to F-actins1326.”
From State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines (2016) · cites this paper as [13]
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“Cofilin is a highly abundant actin-regulatory protein, which binds to and alters the physical properties of F-actin1314.”
From State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines (2016) · cites this paper as [13]
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Cites
Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
Ridley, A. J. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.08.006 · Cited by 1,215
Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics
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Self-citationRate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments.
Pollard, T. D. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2747 · Cited by 890
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Crystal Structure of Arp2/3 Complex
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Minamide, L. S., Striegl, A. M., Boyle, J. A., Meberg, P. J., & Bamburg, J. R. (2000) · Nature Cell Biology · doi:10.1038/35023579 · Cited by 394
Self-citationHotulainen, P., Paunola, E., Vartiainen, M. K., & Lappalainen, P. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0555 · Cited by 384
Oser, M. G., Yamaguchi, H., Mader, C. C., Bravo‐Cordero, J. J., Arias, M., Chen, X., DesMarais, V. M., van Rheenen, J., Koleske, A. J., & Condeelis, J. S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812176 · Cited by 369
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Sun, J., Gao, G., Wang, S., Li, S., Tang, J., Liu, H., & Tang, T.-S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02776-4
Munsie, L. N. (2012) · MacSphere (McMaster University) · doi:10.71548/10111
Metadata
- Authors
- Bernstein, B. W., & Bamburg, J. R.
- Affiliations
- Colorado State University (US)
- Corresponding author
- Bernstein, Barbara W.
- ORCID
- Bamburg, James R.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 20
- Issue
- 4
- Pages
- 187-195
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC2849908
- OpenAlex
- W2082024168
- Cited by
- 704
- References
- 87
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 25 · 2023: 26 · 2022: 31 · 2021: 34 · 2020: 35 · 2019: 36 · 2018: 37 · 2017: 42 · 2016: 58 · 2015: 56 · 2014: 58 · 2013: 86 · 2012: 56
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Alzheimer's Drug Discovery Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS 40371, R01NS040371)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- ADF/cofilin, destrin, actin dynamics, actin depolymerizing factor, protein phosphorylation, apoptosis, phospholipid metabolism, gene expression regulation, homeostatic regulation
- MeSH terms
- Actins, Animals, Fibroblasts, Gene Expression Regulation, HeLa Cells, Humans, Models, Molecular, Neurons, Actin Depolymerizing Factors, Destrin, Mice
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