Cited by 704Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

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ADF/Cofilin: a functional node in cell biology

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Bernstein, Barbara W., Bamburg, James R.·2010·Trends in Cell Biology

DOI 10.1016/j.tcb.2010.01.001PMC PMC2849908

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Abstract

Recent findings have significantly expanded our understanding of the regulation of actin-depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these well-established regulators of actin dynamics have on cell biology. In this review we discuss new aspects of previously documented regulation, such as phosphorylation, but also cover novel recently established modes of regulation and functions of ADF (also known as destrin)/cofilin. We now understand that their activity responds to a vast array of inputs far greater than previously appreciated and that these proteins not only feed back to the crucially important dynamics of actin, but also to apoptosis cascades, phospholipid metabolism, and gene expression. We argue that this ability to respond to physiological changes by modulating those same changes makes the ADF/cofilin protein family a homeostatic regulator or 'functional node' in cell biology.

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Authors: Bernstein, B. W., & Bamburg, J. R.
Affiliations: Colorado State University (US)
Corresponding author: Bernstein, Barbara W.
ORCID: Bamburg, James R.
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2010-04
Volume: 20
Issue: 4
Pages: 187-195
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2010.01.001
PMC: PMC2849908
OpenAlex: W2082024168
Cited by: 704
References: 87
Citations by year: 2026: 21 · 2025: 24 · 2024: 25 · 2023: 26 · 2022: 31 · 2021: 34 · 2020: 35 · 2019: 36 · 2018: 37 · 2017: 42 · 2016: 58 · 2015: 56 · 2014: 58 · 2013: 86 · 2012: 56
FWCI: 6.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Alzheimer's Drug Discovery Foundation
National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS 40371, R01NS040371)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords: ADF/cofilin, destrin, actin dynamics, actin depolymerizing factor, protein phosphorylation, apoptosis, phospholipid metabolism, gene expression regulation, homeostatic regulation
MeSH terms: Actins, Animals, Fibroblasts, Gene Expression Regulation, HeLa Cells, Humans, Models, Molecular, Neurons, Actin Depolymerizing Factors, Destrin, Mice

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ADF/Cofilin: a functional node in cell biology

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