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ADF/Cofilin: a functional node in cell biology
Open accessAbstract
Recent findings have significantly expanded our understanding of the regulation of actin-depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these well-established regulators of actin dynamics have on cell biology. In this review we discuss new aspects of previously documented regulation, such as phosphorylation, but also cover novel recently established modes of regulation and functions of ADF (also known as destrin)/cofilin. We now understand that their activity responds to a vast array of inputs far greater than previously appreciated and that these proteins not only feed back to the crucially important dynamics of actin, but also to apoptosis cascades, phospholipid metabolism, and gene expression. We argue that this ability to respond to physiological changes by modulating those same changes makes the ADF/cofilin protein family a homeostatic regulator or 'functional node' in cell biology.
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“These findings suggest that the diffusion of WT or S3A cofilin, but not S3E cofilin, was significantly impeded by their binding to F-actins1326.”
From State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines (2016) · cites this paper as [13]
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“Cofilin is a highly abundant actin-regulatory protein, which binds to and alters the physical properties of F-actin1314.”
From State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines (2016) · cites this paper as [13]
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Metadata
- Authors
- Bernstein, B. W., & Bamburg, J. R.
- Affiliations
- Colorado State University (US)
- Corresponding author
- Bernstein, Barbara W.
- ORCID
- Bamburg, James R.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 20
- Issue
- 4
- Pages
- 187-195
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC2849908
- OpenAlex
- W2082024168
- Cited by
- 704
- References
- 87
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 25 · 2023: 26 · 2022: 31 · 2021: 34 · 2020: 35 · 2019: 36 · 2018: 37 · 2017: 42 · 2016: 58 · 2015: 56 · 2014: 58 · 2013: 86 · 2012: 56
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Alzheimer's Drug Discovery Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS 40371, R01NS040371)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- ADF/cofilin, destrin, actin dynamics, actin depolymerizing factor, protein phosphorylation, apoptosis, phospholipid metabolism, gene expression regulation, homeostatic regulation
- MeSH terms
- Actins, Animals, Fibroblasts, Gene Expression Regulation, HeLa Cells, Humans, Models, Molecular, Neurons, Actin Depolymerizing Factors, Destrin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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