The molecular biology of spindle assembly checkpoint signaling dynamics.

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The Spindle Assembly Checkpoint

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Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1

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The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores.

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Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

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Short- and long-term effects of chromosome mis-segregation and aneuploidy

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Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

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Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

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Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

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The life and miracles of kinetochores

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The Human Homologue of Bub3 Is Required for Kinetochore Localization of Bub1 and a Mad3/Bub1-related Protein Kinase

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Role of Hec1 in Spindle Checkpoint Signaling and Kinetochore Recruitment of Mad1/Mad2

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The Centromere: Chromatin Foundation for the Kinetochore Machinery

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The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint

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Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1

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Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

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MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

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Sensing centromere tension: Aurora B and the regulation of kinetochore function

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Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

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Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

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The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment

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The KinetochorePreprint

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Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

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Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells

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Checkpoint Protein BubR1 Acts Synergistically with Mad2 to Inhibit Anaphase-promoting Complex

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Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells

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Structure of the mitotic checkpoint complex

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Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint

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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

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Signalling dynamics in the spindle checkpoint response

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The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad1 or Cdc20

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The Mad2 spindle checkpoint protein has two distinct natively folded states

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Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

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Temporal changes in Hec1 phosphorylation control kinetochore–microtubule attachment stability during mitosis

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Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

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Dynamics of Centromere and Kinetochore Proteins

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Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

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Atomic structure of the APC/C and its mechanism of protein ubiquitination

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The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint

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Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

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MAD3 Encodes a Novel Component of the Spindle Checkpoint Which Interacts with Bub3p, Cdc20p, and Mad2p

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Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

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Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

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Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

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Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore

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Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

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Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

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The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

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Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein

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Kinetochore stretching inactivates the spindle assembly checkpoint

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Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

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Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

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Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells

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KNL1/Spc105 Recruits PP1 to Silence the Spindle Assembly Checkpoint

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Panta rhei: The APC/C at steady state

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A dual role for Bub1 in the spindle checkpoint and chromosome congression

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Kinetochore Localization of Spindle Checkpoint Proteins: Who Controls Whom?

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The spindle assembly checkpoint works like a rheostat rather than a toggle switch

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Direct binding between BubR1 and B56–PP2A phosphatase complexes regulate mitotic progression

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Molecular architecture and mechanism of the anaphase-promoting complex

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Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

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Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cellsPreprint

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Bub1 regulates chromosome segregation in a kinetochore-independent manner

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Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

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Mad3p, a pseudosubstrate inhibitor of APC Cdc20 in the spindle assembly checkpointPreprint

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Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

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Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpointPreprint

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A Novel Protein Phosphatase 1-Dependent Spindle Checkpoint Silencing Mechanism

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Spindle assembly checkpoint: the third decade

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Spindle checkpoint proteins and chromosome–microtubule attachment in budding yeast

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Adaptive changes in the kinetochore architecture facilitate proper spindle assembly

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Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20

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APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

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Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling

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BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase

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The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

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Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

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Spindle Checkpoint Silencing Requires Association of PP1 to Both Spc7 and Kinesin-8 Motors

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The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

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Kinetic framework of spindle assembly checkpoint signalling

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Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function

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Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

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Protein Phosphatase 1 Regulates Exit from the Spindle Checkpoint in Budding Yeast

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